Structure-guided antigen engineering yields pneumolysin mutants suitable for vaccination against pneumococcal disease

Journal of Biological Chemistry

Volumn 286, Issue 14, 2011, Pages 12133-12140

  Oloo, Eliud O ^a   Yethon, Jeremy A ^a   Ochs, Martina M ^a   Carpick, Bruce ^a   Oomen, Raymond ^a  

^a Sanofi Pasteur   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOLYTIC ACTIVITY; NEUTRALIZING ANTIBODIES; PORE-FORMING PROTEINS; STANDING PROBLEMS; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL KNOWLEDGE; VACCINE DEVELOPMENT; VIRULENCE FACTORS; WILD TYPES;

ANTIGENS; DETOXIFICATION; VACCINES;

DISEASES;

NEUTRALIZING ANTIBODY; PNEUMOCOCCUS VACCINE; PNEUMOLYSIN;

ARTICLE; CONFORMATIONAL TRANSITION; DETOXIFICATION; HEMOLYSIS; MOLECULAR CLONING; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROTEIN ENGINEERING; STRUCTURE GUIDED ANTIGEN ENGINEERING; TOXIN ANALYSIS;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CALORIMETRY, DIFFERENTIAL SCANNING; CELLS, CULTURED; CIRCULAR DICHROISM; HEMOLYSIS; MUTAGENESIS, SITE-DIRECTED; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; PROTEIN STRUCTURE, SECONDARY; SHEEP; STREPTOLYSINS;

STREPTOCOCCUS PNEUMONIAE;

EID: 79953316626     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.191148     Document Type: Article

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