Mechanism of action of lolitrem B, a fungal endophyte derived toxin that inhibits BK large conductance Ca2+-activated K+ channels

Toxicon

Volumn 57, Issue 5, 2011, Pages 686-694

  Imlach, Wendy L ^a,c,d   Finch, Sarah C ^b   Zhang, Yanli ^a   Dunlop, James ^a   Dalziel, Julie E ^a  

^a AGRESEARCH GRASSLANDS   (New Zealand)

^b RUAKURA RESEARCH CENTRE   (New Zealand)

^c Department of Medicine   (United States)

^d UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

BK channel inhibitor; BK ion channel; Fungal toxin; Large conductance calcium activated potassium channel; Lolitrem; Patch clamp; Paxilline

Indexed keywords

CALCIUM; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LOLITREM B; MYCOTOXIN; PAXILLINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHANNEL GATING; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRIC CONDUCTIVITY; ELECTRIC POTENTIAL; EMBRYO; ENDOPHYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; TOXIN ANALYSIS;

CALCIUM; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MYCOTOXINS; PROTEIN BINDING;

EID: 79953292451     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.01.013     Document Type: Article

References (20)

1. 2+ sensing. J. Gen. Physiol. 2004, 123:475-489.
2. + channels. J. Gen. Physiol. 1997, 109:633-646.
3. Cui J., Yang H., Lee U.S. Molecular mechanisms of BK channel activation. Cell. Mol. Life Sci. 2009, 66:852-875.
4. Dalziel J.E., Finch S.C., Dunlop J. The fungal neurotoxin lolitrem B inhibits the function of human large conductance calcium-activated potassium channels. Toxicol. Lett. 2005, 155:421-426.
5. Gribkoff V.K., Lum-Ragan J.T., Boissard C.G., Post-Munson D.J., Meanwell N.A., Starrett J.E., Kozlowski E.S., Romine J.L., Trojnacki J.T., McKay M.C., Zhong J., Dworetzky S.I. Effects of channel modulators on cloned large-conductance calcium-activated potassium channels. Mol. Pharmacol. 1996, 50:206-217.
6. 2+ binding and channel opening in large conductance (BK) potassium channels. J. Gen. Physiol. 2002, 120:267-305.
7. + channels. Eur. J. Pharmacol. 2009, 605:36-45.
8. Imlach W.L., Finch S.C., Dunlop J., Meredith A.L., Aldrich R.W., Dalziel J.E. The molecular mechanism of ryegrass staggers' a neurological disorder of potassium channels. J. Pharmacol. Exp. Ther. 2008, 327:657-664.
9. Imlach W.L., Finch S.C., Miller J.H., Meredith A.L., Dalziel J.E. A role for BK channels in heart rate regulation in rodents. PloS One 2010, 5:e8698.
10. Knaus H.G., McManus O.B., Lee S.H., Schmalhofer W.A., Garcia-Calvo M., Helms L.M., Sanchez M., Giangiacomo K., Reuben J.P., Smith A.B., et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 1994, 33:5819-5828.
11. Miles C.O., Munday S.C., Wilkins A.L., Ede R.M., Towers N.R. Large-scale isolation of lolitrem B and structure determination of lolitrem E. J. Agric. Food Chem. 1994, 42:1488-1492.
12. Munday-Finch S.C., Wilkins A.L., Miles C.O. Isolation of paspaline B, an indole-diterpenoid from Penicillium paxilli. Phytochemistry 1996, 41:327-332.
13. Nardi A., Olesen S.P. BK channel modulators: a comprehensive overview. Curr. Med. Chem. 2008, 15:1126-1146.
14. Sanchez M., McManus O.B. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology 1996, 35:963-968.
15. Schmalhofer W.A., Sanchez M., Dai G., Dewan A., Secades L., Hanner M., Knaus H.G., McManus O.B., Kohler M., Kaczorowski G.J., Garcia M.L. Role of the C-terminus of the high-conductance calcium-activated potassium channel in channel structure and function. Biochemistry 2005, 44:10135-10144.
16. + channels. J. Gen. Physiol. 2001, 118:589-605.
17. 2+. Neuropharmacology 1996, 35:903-914.
18. Xia X.M., Zeng X., Lingle C.J. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature 2002, 418:880-884.
19. Zeng X.H., Xia X.M., Lingle C.J. Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites. J. Gen. Physiol. 2005, 125:273-286.
20. Zhou Y., Tang Q.Y., Xia O.M., Lingle C.J. Glycine, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix. J. Gen. Physiol. 2010, 135:481-494.