Leptin augments cerebral hemodynamic reserve after three-vessel occlusion: Distinct effects on cerebrovascular tone and proliferation in a nonlethal model of hypoperfused rat brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 4, 2011, Pages 1085-1092

  Busch, Hans Joerg ^a   Schirmer, Stephan H ^b,c   Jost, Marco ^a   Van Stijn, Sylvia ^b   Peters, Stephan L M ^b   Piek, Jan J ^b   Bode, Christoph ^a   Buschmann, Ivo R ^d   Mies, Guenter ^e  

^a UNIVERSITY OF FREIBURG   (Germany)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c SAARLAND UNIVERSITY   (Germany)

^d Research Group for Experimental and Clinical Arteriogenesis   (Germany)

^e MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

arteriogenesis; cerebral hypoperfusion; collateral artery growth; leptin; three vessel occlusion; vascular reactivity

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; LEPTIN; N(G) NITROARGININE METHYL ESTER; PHENYLEPHRINE; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL OCCLUSION; BLOOD VESSEL REACTIVITY; BRAIN PERFUSION; CAROTID ARTERY; CONTROLLED STUDY; ENDOTHELIUM; HEMODYNAMICS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ANTERIOR CEREBRAL ARTERY; BODY WEIGHT; CARBON DIOXIDE; CAROTID ARTERIES; CELL PROLIFERATION; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMODYNAMICS; LEPTIN; MALE; MONOCYTES; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE II; OXYGEN CONSUMPTION; PHENYLEPHRINE; POSTERIOR CEREBRAL ARTERY; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTOR AGENTS;

EID: 79953283485     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.192     Document Type: Article

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