5-formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway

Experimental and Molecular Medicine

Volumn 43, Issue 3, 2011, Pages 146-152

  Zhu, Wei ^a   Fu, Afu ^a   Hu, Jia ^a   Wang, Tianen ^a   Luo, Youfu ^a   Peng, Ming ^a   Ma, Yinghua ^a   Wei, Yuquan ^a   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Angiogenesis inhibitors; Cell movement; Cystoskeleton; Extracellular signal regulated MAP kinases; Honokiol

Indexed keywords

5 FORMYLHONOKIOL; ANGIOGENESIS INHIBITOR; F ACTIN; HONOKIOL; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL DISRUPTION; CELL INVASION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; EMBRYO; ENZYME INACTIVATION; ENZYME REPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MIGRATION INHIBITION; NONHUMAN; SIGNAL TRANSDUCTION; STRESS FIBER; TUMOR VASCULARIZATION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; WOUND HEALING; ZEBRA FISH;

DANIO RERIO;

EID: 79953273779     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2011.43.3.017     Document Type: Article

References (32)

1. Bai X, Cerimele F, Ushio-Fukai M, Waqas M, Campbell PM, Govindarajan B, Der CJ, Battle T, Frank DA, Ye K, Murad E, Dubiel W, Soff G, Arbiser JL. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem 2003; 278:35501-7
2. Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3:401-10
3. Berra E, Milanini J, Richard DE, Gall ML, Vinals F, Gothie E, Roux D, Pades G, Pouyssegur J. Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. Biochem Pharmacol 2000; 60:1171-8
4. Carmeliet P. Angiogenesis in cancer and other diseases. Nature 2000; 407:249-57
5. Chan J, Bayliss PE, Wood JM, Robert TM. Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell 2002; 1:257-67
6. Chiou WF, Don MJ. Cryptotanshinone inhibits macrophage migration by impeding F-actin polymerization and filopodia extension. Life Sci 2007; 81:109-14
7. Cooney MM, Heeckeren WV, Bhakta S, Ortiz J, Remick SC. Drug insight: vascular disrupting agents and angiogenesis-novel approaches for drug delivery. Nat Clin Pract Oncol 2006; 3:682-92
8. Coultas L, Chawengsaksophak K, Rossant J. Endothelial cells and VEGF in vascular development. Nature 2005; 438:937-45
9. Cross LM, Cook MA, Lin S, Chen JN, Rubinstein AL. Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arterioscler Thromb Vasc Biol 2003; 23:911-2
10. Depeille P, Young JJ, Boguslawski EA, Berghuis BD, Kort EJ, Resau JH, Frankel AE, Duesbery NS. Anthrax lethal toxin inhibits growth of and vascular endothelial growth factor release from endothelial cells expressing the human herpes virus 8 viral g protein coupled receptor. Clin Cancer Res 2007; 13:5926-34
11. Dong DF, Li EX, Wang JB, Wu YY, Shi F, Guo JJ, Wu Y, Liu JP, Liu SX, Yang GX. Anti-angiogenesis and anti-tumor effects of AdNT4-anginex. Cancer Lett 2009; 285:218-24
12. Dong G, Chen Z, Li ZY, Yeh NT, Bancroft CC, Waes CV. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res 2001; 61:5911-8
13. Folkman J. Tumor angiogenesis factor. Cancer Res 1974; 34: 2109-13
14. Huang D, Ding Y, Luo WM, Bender S, Qian CN, Kort E, Zhang ZF, VandenBeldt K, Duesbery NS, Resau JH, Teh BT. Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo. Cancer Res 2008; 68:81-8
15. Huang SM, Li J, Harari PM. Molecular Inhibition of angio-genesis and metastatic potential in human squamous cell carcinomas after epidermal growth factor receptor blockade. Mol Cancer Ther 2002; 1:507-14
16. Ikeda K, Sakai Y, Nagase H. Inhibitory effect of magnolol on tumour metastasis in mice. Phytother Res 2003; 17:933-7
17. Jain RK. Molecular regulation of vessel maturation. Nat Med 2003; 9:685-93
18. Kedrin D, Rheenen JV, Hernandez L, Condeelis J, Segall JE. Cell motility and cytoskeletal regulation in invasion and metastasis. J Mammary Gland Biol Neoplasia 2007; 12: 143-52
19. Kim DW, Lu B, Hallahan DE. Receptor tyrosine kinase inhibitors as anti-angiogenic agents. Curr Opin Investig Drugs 2004; 5:597-604
20. Lu B, Shinohara ET, Edwards E, Geng L, Tan J, Hallahan DE. The use of tyrosine kinase inhibitors in modifying the response of tumor microvasculature to radiotherapy. Technol Cancer Res Treat 2005; 4:691-8
21. Luo Y, Xu Y, Chen L, Hu J, Peng C, Xie D, Shi J, Huang W, Xu G, Peng M, Han J, Li R, Yang S, Wei Y. Semi-synthesis and anti-proliferative activity evaluation of novel analogues of honokiol. Bioorg Med Chem Lett 2009; 19:4702-5
22. Murphy DA, Makonnen S, Lassoued W, Feldman MD, Carter C, Lee WM. Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006). Am J Pathol 2006; 169:1875-85
23. Perona R. Cell signalling: growth factors and tyrosine kinase receptors. Clin Transl Oncol 2006; 8:77-82
24. Tak H, Jang E, Kim SB, Park J, Suk J, Yoon YS, Ahn JK, Lee JH, Joe CO. 14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization. Cell Signal 2007; 19:2379-87
25. Taraboletti G, Giavazzi R. Modelling approaches for angiogenesis. Eur J Cancer 2004; 40:881-9
26. Tong YG, Zhang XW, Geng MY, Yue JM, Xin XL, Tian F, Shen X, Tong LJ, Li MH, Zhang C, Li WH, Lin LP, Ding J. Pseudolarix acid b, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin. Mol Pharmacol 2006; 69:1226-33
27. Vicker MG. Reaction-diffusion waves of actin filament polymerization/depolymerization in dictyostelium pseudo-podium extension and cell locomotion. Biophys Chem 2000; 84:87-98
28. Wang W, Zhang WL, Han Y, Chen JZ, Wang YB, Zhang Z, Hui RT. NELIN, a new F-actin associated protein, stimulates HeLa cell migration and adhesion. Biochem Biophys Res Commun 2005; 330:1127-31
29. Ward Y, Wang W, Woodhouse E, Linnoila I, Liotta L, Kelly K. Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways. Mol Cell Biol 2001; 21:5958-69
30. Wen J, Fu AF, Chen LJ, Xie XJ, Yang GL, Chen XC, Wang YS, Li J, Chen P, Tang MH, Shao XM, Lu Y, Zhao X, Wei YQ. Liposomal honokiol inhibits VEGF-D-induced lymphangio-genesis and metastasis in xenograft tumor model. Int J Cancer 2009; 124:2709-18
31. Xiao D, Singh SV. z-Guggulsterone, a constituent of ayurvedic medicinal plant commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther 2008; 7:171-80
32. Yi TF, Cho SG, Yi ZF, Pang XF, Rodriguez M, Wang Y, Sethi G, Aggarwal BB, Liu MY. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol Cancer Ther 2008; 7:1789-96