-
1
-
-
3042744030
-
Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: Results from phase I/II studies
-
DOI 10.1200/JCO.2004.11.120
-
Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies. F Izzo P Marra G Beneduce G Castello P Vallone V De Rosa F Cremona CM Ensor FW Holtsberg JS Bomalaski,, et al. J Clin Oncol 2004 22 1815 1822 10.1200/JCO.2004.11.120 15143074 (Pubitemid 41095171)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.10
, pp. 1815-1822
-
-
Izzo, F.1
Marra, P.2
Beneduce, G.3
Castello, G.4
Vallone, P.5
De Rosa, V.6
Cremona, F.7
Ensor, C.M.8
Holtsberg, F.W.9
Bomalaski, J.S.10
Clark, M.A.11
Ng, C.12
Curley, S.A.13
-
2
-
-
32944469353
-
Pegylated arginine deiminase treatment of patients with metastatic melanoma: Results from phase I and II studies
-
DOI 10.1200/JCO.2005.02.0933
-
Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies. PA Ascierto S Scala G Castello A Daponte E Simeone A Ottaiano G Beneduce V De Rosa F Izzo MT Melucci,, et al. J Clin Oncol 2005 23 7660 7668 10.1200/JCO.2005.02.0933 16234528 (Pubitemid 46291831)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.30
, pp. 7660-7668
-
-
Ascierto, P.A.1
Scala, S.2
Castello, G.3
Daponte, A.4
Simeone, E.5
Ottaiano, A.6
Beneduce, G.7
De Rosa, V.8
Izzo, F.9
Melucci, M.T.10
Ensor, C.M.11
Prestayko, A.W.12
Holtsberg, F.W.13
Bomalaski, J.S.14
Clark, M.A.15
Savaraj, N.16
Feun, L.G.17
Logan, T.F.18
-
3
-
-
28844493579
-
Modulation of arginine metabolic pathways as the potential anti-tumor mechanism of recombinant arginine deiminase
-
DOI 10.1016/j.canlet.2005.01.007, PII S0304383505000406
-
Modulation of arginine metabolic pathways as the potential anti-tumor mechanism of recombinant arginine deiminase. LJ Shen K Beloussow WC Shen, Cancer Lett 2006 231 30 35 10.1016/j.canlet.2005.01.007 16356828 (Pubitemid 41779450)
-
(2006)
Cancer Letters
, vol.231
, Issue.1
, pp. 30-35
-
-
Shen, L.-J.1
Beloussow, K.2
Shen, W.-C.3
-
4
-
-
0036792124
-
Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo
-
12359751
-
Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. CM Ensor FW Holtsberg JS Bomalaski MA Clark, Cancer Res 2002 62 5443 5450 12359751
-
(2002)
Cancer Res
, vol.62
, pp. 5443-5450
-
-
Ensor, C.M.1
Holtsberg, F.W.2
Bomalaski, J.S.3
Clark, M.A.4
-
5
-
-
45549107064
-
Arginine deprivation as a targeted therapy for cancer
-
DOI 10.2174/138161208784246199
-
Arginine deprivation as a targeted therapy for cancer. L Feun M You CJ Wu MT Kuo M Wangpaichitr S Spector N Savaraj, Curr Pharm Des 2008 14 1049 1057 10.2174/138161208784246199 18473854 (Pubitemid 351982554)
-
(2008)
Current Pharmaceutical Design
, vol.14
, Issue.11
, pp. 1049-1057
-
-
Feun, L.1
You, M.2
Wu, C.J.3
Kuo, M.T.4
Wangpaichitr, M.5
Spector, S.6
Savaraj, N.7
-
6
-
-
0037430556
-
Resistance to the anti-proliferative activity of recombinant arginine deiminase in cell culture correlates with the endogenous enzyme, argininosuccinate synthetase
-
DOI 10.1016/S030-43835(02)00693-6
-
Resistance to the anti-proliferative activity of recombinant arginine deiminase in cell culture correlates with the endogenous enzyme, argininosuccinate synthetase. LJ Shen WC Lin K Beloussow WC Shen, Cancer Lett 2003 191 165 170 10.1016/S030-43835(02)00693-6 12618329 (Pubitemid 36255601)
-
(2003)
Cancer Letters
, vol.191
, Issue.2
, pp. 165-170
-
-
Shen, L.-J.1
Lin, W.-C.2
Beloussow, K.3
Shen, W.-C.4
-
7
-
-
21344457432
-
RNA interference: From gene silencing to gene-specific therapeutics
-
DOI 10.1016/j.pharmthera.2005.03.004, PII S0163725805000628
-
RNA interference: from gene silencing to gene-specific therapeutics. RK Leung PA Whittaker, Pharmacol Ther 2005 107 222 239 10.1016/j.pharmthera.2005. 03.004 15908010 (Pubitemid 40910042)
-
(2005)
Pharmacology and Therapeutics
, vol.107
, Issue.2
, pp. 222-239
-
-
Leung, R.K.M.1
Whittaker, P.A.2
-
8
-
-
36749094533
-
Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs
-
DOI 10.1016/j.pharmthera.2007.08.004, PII S0163725807001751
-
Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs. M Yang J Mattes, Pharmacol Ther 2008 117 94 104 10.1016/j.pharmthera.2007.08.004 17928059 (Pubitemid 350199690)
-
(2008)
Pharmacology and Therapeutics
, vol.117
, Issue.1
, pp. 94-104
-
-
Yang, M.1
Mattes, J.2
-
9
-
-
13844280638
-
Synthetic shRNAs as potent RNAi triggers
-
DOI 10.1038/nbt1052
-
Synthetic shRNAs as potent RNAi triggers. D Siolas C Lerner J Burchard W Ge PS Linsley PJ Paddison GJ Hannon MA Cleary, Nat Biotechnol 2005 23 227 231 10.1038/nbt1052 15619616 (Pubitemid 40255334)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.2
, pp. 227-231
-
-
Siolas, D.1
Lerner, C.2
Burchard, J.3
Ge, W.4
Linsley, P.S.5
Paddison, P.J.6
Hannon, G.J.7
Cleary, M.A.8
-
10
-
-
0036245743
-
Expanding small RNA interference
-
DOI 10.1038/nbt0502-446
-
Expanding small RNA interference. T Tuschl, Nat Biotechnol 2002 20 446 448 10.1038/nbt0502-446 11981553 (Pubitemid 34495927)
-
(2002)
Nature Biotechnology
, vol.20
, Issue.5
, pp. 446-448
-
-
Tuschl, T.1
-
11
-
-
57049153966
-
Recombinant arginine deiminase reduces inducible nitric oxide synthase iNOS-mediated neurotoxicity in a coculture of neurons and microglia
-
10.1002/jnr.21740. 18627024
-
Recombinant arginine deiminase reduces inducible nitric oxide synthase iNOS-mediated neurotoxicity in a coculture of neurons and microglia. HH Yu FL Wu SE Lin LJ Shen, J Neurosci Res 2008 86 2963 2972 10.1002/jnr.21740 18627024
-
(2008)
J Neurosci Res
, vol.86
, pp. 2963-2972
-
-
Yu, H.H.1
Wu, F.L.2
Lin, S.E.3
Shen, L.J.4
-
12
-
-
0037173613
-
Short interfering RNA confers intracellular antiviral immunity in human cells
-
DOI 10.1038/nature00873
-
Short interfering RNA confers intracellular antiviral immunity in human cells. L Gitlin S Karelsky R Andino, Nature 2002 418 430 434 10.1038/nature00873 12087357 (Pubitemid 34826844)
-
(2002)
Nature
, vol.418
, Issue.6896
, pp. 430-434
-
-
Gitlin, L.1
Karelsky, S.2
Andino, R.3
-
13
-
-
0031611295
-
Tetrazolium (MTT) assay for cellular viability and activity
-
9463833
-
Tetrazolium (MTT) assay for cellular viability and activity. DM Morgan, Methods Mol Biol 1998 79 179 183 9463833
-
(1998)
Methods Mol Biol
, vol.79
, pp. 179-183
-
-
Morgan, D.M.1
-
14
-
-
68249136697
-
Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer
-
10.1002/ijc.24546. 19533750
-
Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer. LJ Nicholson PR Smith L Hiller PW Szlosarek C Kimberley J Sehouli D Koensgen A Mustea P Schmid T Crook, Int J Cancer 2009 125 1454 1463 10.1002/ijc.24546 19533750
-
(2009)
Int J Cancer
, vol.125
, pp. 1454-1463
-
-
Nicholson, L.J.1
Smith, P.R.2
Hiller, L.3
Szlosarek, P.W.4
Kimberley, C.5
Sehouli, J.6
Koensgen, D.7
Mustea, A.8
Schmid, P.9
Crook, T.10
-
15
-
-
33845761445
-
In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion
-
DOI 10.1158/1078-0432.CCR-06-1101
-
In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion. PW Szlosarek A Klabatsa A Pallaska M Sheaff P Smith T Crook MJ Grimshaw JP Steele RM Rudd FR Balkwill DA Fennell, Clin Cancer Res 2006 12 7126 7131 10.1158/1078-0432.CCR-06-1101 17145837 (Pubitemid 44974513)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.23
, pp. 7126-7131
-
-
Szlosarek, P.W.1
Klabatsa, A.2
Pallaska, A.3
Sheaff, M.4
Smith, P.5
Crook, T.6
Grimshaw, M.J.7
Steele, J.P.8
Rudd, R.M.9
Balkwill, F.R.10
Fennell, D.A.11
-
16
-
-
47249136177
-
The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma
-
The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma. N Savaraj, Drug Target Insights 2007 2 119 128
-
(2007)
Drug Target Insights
, vol.2
, pp. 119-128
-
-
Savaraj, N.1
-
17
-
-
0034653804
-
Single amino acid (arginine) deprivation induces G1 arrest associated with inhibition of Cdk4 expression in cultured human diploid fibroblasts
-
DOI 10.1006/excr.1999.4779
-
Single amino acid (arginine) deprivation induces G1 arrest associated with inhibition of cdk4 expression in cultured human diploid fibroblasts. J Lamb DN Wheatley, Exp Cell Res 2000 255 238 249 10.1006/excr.1999.4779 10694439 (Pubitemid 30143857)
-
(2000)
Experimental Cell Research
, vol.255
, Issue.2
, pp. 238-249
-
-
Lamb, J.1
Wheatley, D.N.2
-
18
-
-
0037463235
-
Arginine deprivation, growth inhibition and tumour cell death: 2. Enzymatic degradation of arginine in normal and malignant cell cultures
-
DOI 10.1038/sj.bjc.6600681
-
Arginine deprivation, growth inhibition and tumour cell death: 2. Enzymatic degradation of arginine in normal and malignant cell cultures. R Philip E Campbell DN Wheatley, Br J Cancer 2003 88 613 623 10.1038/sj.bjc. 6600681 12592378 (Pubitemid 36363373)
-
(2003)
British Journal of Cancer
, vol.88
, Issue.4
, pp. 613-623
-
-
Philip, R.1
Campbell, E.2
Wheatley, D.N.3
-
19
-
-
0033822017
-
Single amino acid (arginine) deprivation: Rapid and selective death of cultured transformed and malignant cells
-
10.1054/bjoc.2000.1353. 10952786
-
Single amino acid (arginine) deprivation: rapid and selective death of cultured transformed and malignant cells. L Scott J Lamb S Smith DN Wheatley, Br J Cancer 2000 83 800 810 10.1054/bjoc.2000.1353 10952786
-
(2000)
Br J Cancer
, vol.83
, pp. 800-810
-
-
Scott, L.1
Lamb, J.2
Smith, S.3
Wheatley, D.N.4
-
20
-
-
0345109251
-
Arginine deiminase inhibits cell proliferation by arresting cell cycle and inducing apoptosis
-
DOI 10.1006/bbrc.1999.1004
-
Arginine deiminase inhibits cell proliferation by arresting cell cycle and inducing apoptosis. H Gong F Zolzer G von Recklinghausen J Rossler S Breit W Havers T Fotsis L Schweigerer, Biochem Biophys Res Commun 1999 261 10 14 10.1006/bbrc.1999.1004 10405315 (Pubitemid 29371610)
-
(1999)
Biochemical and Biophysical Research Communications
, vol.261
, Issue.1
, pp. 10-14
-
-
Gong, H.1
Zolzer, F.2
Von Recklinghausen, G.3
Rossler, J.4
Breit, S.5
Havers, W.6
Fotsis, T.7
Schweigerer, L.8
-
21
-
-
0342748603
-
Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis
-
Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis. H Gong F Zolzer G von Recklinghausen W Havers L Schweigerer, Leukemia 2000 14 826 829 10.1038/sj.leu.2401763 10803513 (Pubitemid 30235059)
-
(2000)
Leukemia
, vol.14
, Issue.5
, pp. 826-829
-
-
Gong, H.1
Zolzer, F.2
Von Recklinghausen, G.3
Havers, W.4
Schweigerer, L.5
-
22
-
-
58349098150
-
Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis
-
10.1158/0008-5472.CAN-08-3157. 19147587
-
Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. RH Kim JM Coates TL Bowles GP McNerney J Sutcliffe JU Jung R Gandour-Edwards FY Chuang RJ Bold HJ Kung, Cancer Res 2009 69 700 708 10.1158/0008-5472.CAN-08-3157 19147587
-
(2009)
Cancer Res
, vol.69
, pp. 700-708
-
-
Kim, R.H.1
Coates, J.M.2
Bowles, T.L.3
McNerney, G.P.4
Sutcliffe, J.5
Jung, J.U.6
Gandour-Edwards, R.7
Chuang, F.Y.8
Bold, R.J.9
Kung, H.J.10
-
23
-
-
13844281898
-
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
-
DOI 10.1038/nbt1051
-
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. DH Kim MA Behlke SD Rose MS Chang S Choi JJ Rossi, Nat Biotechnol 2005 23 222 226 10.1038/nbt1051 15619617 (Pubitemid 40255333)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.2
, pp. 222-226
-
-
Kim, D.-H.1
Behlke, M.A.2
Rose, S.D.3
Chang, M.-S.4
Choi, S.5
Rossi, J.J.6
-
24
-
-
1942499451
-
Improving the efficiency of RNA interference in mammals
-
DOI 10.1038/nrg1323
-
Improving the efficiency of RNA interference in mammals. V Mittal, Nat Rev Genet 2004 5 355 365 10.1038/nrg1323 15143318 (Pubitemid 38529407)
-
(2004)
Nature Reviews Genetics
, vol.5
, Issue.5
, pp. 355-365
-
-
Mittal, V.1
-
25
-
-
0036440779
-
Regulation of mammalian translation factors by nutrients
-
DOI 10.1046/j.1432-1033.2002.03292.x
-
Regulation of mammalian translation factors by nutrients. CG Proud, Eur J Biochem 2002 269 5338 5349 10.1046/j.1432-1033.2002.03292.x 12423332 (Pubitemid 35365523)
-
(2002)
European Journal of Biochemistry
, vol.269
, Issue.22
, pp. 5338-5349
-
-
Proud, C.G.1
-
27
-
-
23844519418
-
Integrity and stability of the citrulline-arginine pathway in normal and tumour cell lines
-
DOI 10.1016/j.canlet.2005.01.004, PII S0304383505000455
-
Integrity and stability of the citrulline-arginine pathway in normal and tumour cell lines. DN Wheatley R Kilfeather A Stitt E Campbell, Cancer Lett 2005 227 141 152 10.1016/j.canlet.2005.01.004 16112417 (Pubitemid 41169927)
-
(2005)
Cancer Letters
, vol.227
, Issue.2
, pp. 141-152
-
-
Wheatley, D.N.1
Kilfeather, R.2
Stitt, A.3
Campbell, E.4
-
28
-
-
33744908869
-
Drug evaluation: ADI-PEG-20 - A PEGylated arginine deiminase for arginine-auxotrophic cancers
-
16774044
-
Drug evaluation: ADI-PEG-20 - a PEGylated arginine deiminase for arginine-auxotrophic cancers. LJ Shen WC Shen, Curr Opin Mol Ther 2006 8 240 248 16774044
-
(2006)
Curr Opin Mol Ther
, vol.8
, pp. 240-248
-
-
Shen, L.J.1
Shen, W.C.2
-
29
-
-
0842325861
-
Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: A method for identifying cancers sensitive to arginine deprivation
-
DOI 10.1002/cncr.20057
-
Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation. BJ Dillon VG Prieto SA Curley CM Ensor FW Holtsberg JS Bomalaski MA Clark, Cancer 2004 100 826 833 10.1002/cncr.20057 14770441 (Pubitemid 38176863)
-
(2004)
Cancer
, vol.100
, Issue.4
, pp. 826-833
-
-
Dillon, B.J.1
Prieto, V.G.2
Curley, S.A.3
Ensor, C.M.4
Holtsberg, F.W.5
Bomalaski, J.S.6
Clark, M.A.7
-
30
-
-
33846625891
-
Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase
-
10.1002/ijc.22322. 17096330
-
Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase. CY Yoon YJ Shim EH Kim JH Lee NH Won JH Kim IS Park DK Yoon BH Min, Int J Cancer 2007 120 897 905 10.1002/ijc.22322 17096330
-
(2007)
Int J Cancer
, vol.120
, pp. 897-905
-
-
Yoon, C.Y.1
Shim, Y.J.2
Kim, E.H.3
Lee, J.H.4
Won, N.H.5
Kim, J.H.6
Park, I.S.7
Yoon, D.K.8
Min, B.H.9
-
31
-
-
51949087021
-
Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase
-
10.1002/ijc.23723. 18661517
-
Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase. TL Bowles R Kim J Galante CM Parsons S Virudachalam HJ Kung RJ Bold, Int J Cancer 2008 123 1950 1955 10.1002/ijc.23723 18661517
-
(2008)
Int J Cancer
, vol.123
, pp. 1950-1955
-
-
Bowles, T.L.1
Kim, R.2
Galante, J.3
Parsons, C.M.4
Virudachalam, S.5
Kung, H.J.6
Bold, R.J.7
|