Recombinant arginine deiminase reduces inducible nitric oxide synthase iNOS-mediated neurotoxicity in a coculture of neurons and microglia

Journal of Neuroscience Research

Volumn 86, Issue 13, 2008, Pages 2963-2972

  Yu, Hao Hsin ^a   Wu, Fe Lin Lin ^a,b   Lin, Shan Erh ^a   Shen, Li Jiuan ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Arginine deiminase; Coculture; iNOS; Neuroprotection; Nitric oxide

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ARGININE; ARGININE DEIMINASE; DOPAMINE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ARTICLE; BRAIN DISEASE; BRAIN NERVE CELL; CELL VIABILITY; COCULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOPAMINE UPTAKE; ENZYME INDUCTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MICROGLIA; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

ARGININE; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; COCULTURE TECHNIQUES; FLOW CYTOMETRY; HUMANS; HYDROLASES; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RECOMBINANT PROTEINS;

EID: 57049153966     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21740     Document Type: Article

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