[125I]lodoproxyfan and related compounds: A reversible radioligand and novel classes of antagonists with high affinity and selectivity for the histamine H3 receptor

Journal of Medicinal Chemistry

Volumn 39, Issue 6, 1996, Pages 1220-1226

  Stark, Holger ^a   Purand, Katja ^a   Hüls, Annette ^a   Ligneau, Xavier ^b   Garbarg, Monique ^c   Schwartz, Jean Charles ^c   Schunack, Walter ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Laboratoire Bioprojet   (France)

^c CENTRE PAUL BROCA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA METHYLHISTAMINE; HISTAMINE H3 RECEPTOR ANTAGONIST; IMIDAZOLE DERIVATIVE; IODINE DERIVATIVE; IODOPROXYFAN; N METHYLHISTAMINE; ALPHA-METHYLHISTAMINE; ANTIHISTAMINIC AGENT; DIAGNOSTIC AGENT; HISTAMINE DERIVATIVE; RADIOACTIVE IODINE;

ANIMAL TISSUE; BRAIN CORTEX; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HISTAMINE RELEASE; HYDROGEN BOND; LIGAND BINDING; NEGATIVE FEEDBACK; NONHUMAN; RECEPTOR AFFINITY; REVIEW; STRUCTURE ACTIVITY RELATION; SYNAPTOSOME; ANIMAL; ARTICLE; GUINEA PIG; IN VITRO STUDY; METABOLISM; RADIOASSAY; RAT; SYNTHESIS;

ANIMALS; CEREBRAL CORTEX; GUINEA PIGS; HISTAMINE ANTAGONISTS; IMIDAZOLES; IODINE RADIOISOTOPES; METHYLHISTAMINES; RADIOLIGAND ASSAY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029665590     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9504767     Document Type: Article

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