Structural and biochemical elucidation of mechanism for decarboxylative condensation of β-keto acid by curcumin synthase

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6659-6668

  Katsuyama, Yohei ^a   Miyazono, Ken Ichi ^a   Tanokura, Masaru ^a   Ohnishi, Yasuo ^a   Horinouchi, Sueharu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL-COA; BIOCHEMICAL STUDIES; CATALYTIC CENTER; CURCUMIN; HYDROPHOBIC CAVITIES; HYDROPHOBIC INTERACTIONS; KETO ACIDS; MALONYL-COA; MODELING STUDIES; POLYKETIDE SYNTHASES; REACTION CATALYZED; SIDE CHAINS; SUBSTRATE BINDING; SUBSTRATE SPECIFICITY; SYNTHASES;

CATALYSIS; CONDENSATION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; SUBSTRATES; SYNTHESIS (CHEMICAL);

HYDROPHOBICITY;

CURCUMIN SYNTHASE 1; GLYCINE; MALONYL COENZYME A; OXOACID; PHENYLALANINE; POLYKETIDE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; HYDROPHOBICITY; MOLECULAR INTERACTION; MUTANT; NUCLEOTIDE SEQUENCE; POLYMERIZATION; PRIORITY JOURNAL;

BINDING SITES; COENZYME A; CRYSTALLOGRAPHY, X-RAY; CURCUMA; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGASES; MODELS, MOLECULAR; PLANT PROTEINS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953214578     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.196279     Document Type: Article

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