Asymmetric chemoenzymatic synthesis of miconazole and econazole enantiomers. the importance of chirality in their biological evaluation

Journal of Organic Chemistry

Volumn 76, Issue 7, 2011, Pages 2115-2122

  Mangas Sánchez, Juan ^a   Busto, Eduardo ^a   Gotor Fernández, Vicente ^a   Malpartida, Francisco ^b   Gotor, Vicente ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ASPERGILLUS NIGER; BIOLOGICAL ACTIVITIES; BIOLOGICAL EVALUATION; BIOREDUCTIONS; CANDIDA KRUSEI; CHEMO-ENZYMATIC SYNTHESIS; CHEMOENZYMATIC ROUTE; CRYPTOCOCCUS NEOFORMANS; ENANTIOPURE; MILD REACTION CONDITIONS; OXIDOREDUCTASES; PENICILLIUM CHRYSOGENUM; RACEMIC ALCOHOLS; STEREOSELECTIVE PROCESS;

ACETYLATION; BIOACTIVITY; CHEMICAL MODIFICATION; ENANTIOMERS; ENZYME ACTIVITY; ENZYMES; ETHANOL; KETONES; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

CHIRALITY;

1 (2,4 DICHLOROPHENYL) 2 (1H IMIDAZOL 1YL)ETHANOL; 1 [2 (2,4 DICHLOROBENZYLOXY) 2 (2,4 DICHLOROPHENYL)ETHYL] 1 H IMIDAZOLE; 1 [2 (4 CHLOROBENZYLOXY) 2 (2,4 DICHLOROPHENYL)ETHYL] 1H IMIDAZOLE; 2 (2,4 DICHLOROPHENYL)OXIRANE; 2 BROMO 1 (2,4 DICHLOROPHENYL)ETHANONE; 2 CHLORO 1 (2,4 DICHLOROPHENYL)ETHANOL; 2 CHLORO 1 (2,4 DICHLOROPHENYL)ETHYL CHLOROACETATE; 2,2',4' TRICHLOROACETOPHENONE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALCOHOL DERIVATIVE; ANTIFUNGAL AGENT; ECONAZOLE; KETONE; MICONAZOLE; OXIDOREDUCTASE; SERTACONAZOLE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ACETYLATION; ANTIFUNGAL ACTIVITY; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; ASPERGILLUS NIGER; CANDIDA KRUSEI; CHEMICAL MODIFICATION; CHIRALITY; CRYPTOCOCCUS NEOFORMANS; DRUG STRUCTURE; ENANTIOMER; MICROBIAL GROWTH; PENICILLIUM CHRYSOGENUM; REDUCTION; STEREOCHEMISTRY; SYNTHESIS;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA; ECONAZOLE; HUMANS; HYDROCARBONS, CHLORINATED; LIPASE; MAGNETIC RESONANCE SPECTROSCOPY; MICONAZOLE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 79953201880     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo102459w     Document Type: Article

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