A switch in enantiomer preference between mitochondrial F1F 0-ATPase chemotypes

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 11, 2005, Pages 2749-2751

  Bisaha, Sharon N ^a   Malley, Mary F ^a   Pudzianowski, Andrew ^a   Monshizadegan, Hossain ^a   Wang, Paulina ^a   Madsen, Cort S ^a   Gougoutas, Jack Z ^a   Stein, Philip D ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Acylguanidine; Chiral synthesis; Mitochondrial ATPase

Indexed keywords

HYDROLASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; PHARMACOPHORE; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; MITOCHONDRIA; MODELS, MOLECULAR; PROTON-TRANSLOCATING ATPASES; STEREOISOMERISM;

EID: 19544385605     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.115     Document Type: Article

References (13)

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10. 3. Enantiomeric excess (% ee) was determined by chiral chromatography
11. Crystallographic data (excluding structure factors) for 6b have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication numbers CCDC 251489 and 251490. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK [fax: +44 (0) 1223 336033 or e-mail: deposit@ccdc.cam.ac.uk ]
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