Perioperative blood transfusion requirements in pediatric scoliosis surgery: The efficacy of tranexamic acid

Journal of Pediatric Orthopaedics

Volumn 29, Issue 3, 2009, Pages 300-304

  Grant, John A ^a   Howard, Jason ^a   Luntley, Jeremy ^a   Harder, James ^a   Aleissa, Sami ^a   Parsons, David ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Antifibrinolytic; Idiopathic scoliosis; Tranexamic acid; Transfusion

Indexed keywords

FRESH FROZEN PLASMA; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ARTICLE; BLEEDING; BLOOD TRANSFUSION; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG MEGADOSE; ERYTHROCYTE TRANSFUSION; HUMAN; IDIOPATHIC SCOLIOSIS; LOADING DRUG DOSE; LOW DRUG DOSE; PEDIATRIC SURGERY; PERIOPERATIVE PERIOD; POSTOPERATIVE CARE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPINE FUSION; THROMBOCYTE TRANSFUSION; ADOLESCENT; CHILD; COMPARATIVE STUDY; FEMALE; MALE; METHODOLOGY; SCOLIOSIS;

ADOLESCENT; ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; PERIOPERATIVE CARE; RETROSPECTIVE STUDIES; SCOLIOSIS; SPINAL FUSION; TRANEXAMIC ACID;

EID: 67649869963     PISSN: 02716798     EISSN: None     Source Type: Journal    
DOI: 10.1097/BPO.0b013e31819a85de     Document Type: Article

References (29)

1. Cole JW, Murray DJ, Snider RJ, et al. Aprotinin reduces blood loss during spinal surgery in children. Spine. 2003;28(21):2482-2485.
2. Florentino-Pineda I, Thompson GH, Poe-Kochert C, et al. The effect of amicar on perioperative blood loss in idiopathic scoliosis: the results of a prospective, randomized double-blind study. Spine. 2004;29(3):233-238.
3. Khoshhal K, Mukhtar I, Clark P, et al. Efficacy of aprotinin in reducing blood loss in spinal fusion for idiopathic scoliosis. J Pediatr Orthop. 2003;23(5):661-664.
4. Letts M, Pang E, D'Astous J, et al. The influence of desmopressin on blood loss during spinal fusion surgery in neuromuscular patients. Spine. 1998;23(4):475-478.
5. Neilipovitz DT, Murto K, Hall L, et al. A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery. Anesth Analg. 2001;93(1):82-87.
6. Sethna NF, Zurakowski D, Brustowicz RM, et al. Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Anesthesiology. 2005;102(4):727-732.
7. Murray DJ, Forbes RB, Titone MB, et al. Transfusion management in pediatric and adolescent scoliosis surgery. Efficacy of autologous blood. Spine. 1997;22(23):2735-2740.
8. Chiavetta JA, Escobar M, Newman A, et al. Incidence and estimated rates of residual risk for HIV, hepatitis C, hepatitis B and human T-cell lymphotropic viruses in blood donors in Canada, 1990-2000. CMAJ. 2003;169(8):767-773.
9. Robillard P, Nawej KI, Jochem K. The Quebec hemovigilance system: description and results from the first two years. Transfus Apher Sci. 2004;31(2):111-122.
10. Aoun E, Shamseddine A, Chehal A, et al. Transfusion-associated GVHD: 10 years' experience at the American University of Beirut-Medical Center. Transfusion. 2003;43(12):1672-1676.
11. Hardy JF, De Moerloose P, Samama M. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth. 2004;51(4):293-310.
12. Meikle A, Milne B. Management of prolonged QT interval during a massive transfusion: calcium, magnesium or both? Can J Anaesth. 2000;47(8):792-795.
13. Shafi S, Kauder DR. Fluid resuscitation and blood replacement in patients with polytrauma. Clin Orthop Relat Res. 2004;422:37-42.
14. Fergusson DA, Hebert PC, Mazer CD, et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med. 2008;358(22):2319-2331.
15. Early communiation about an ongoing safety review: aprotinin injection (marketed as Trasylol). U. S. Food and Drug Administration Center for Drug Evaluation and Research. October 25, 2007. Available at: http:// www.fda.gov/cder/drug/early-comm/aprotinin.htm. Accessed March 28, 2008.
16. Shaw AD, Stafford-Smith M, White WD, et al. The effect of aprotinin on outcome after coronary-artery bypass grafting. N Engl J Med. 2008;358(8):784-793.
17. Schneeweiss S, Seeger JD, Landon J, et al. Aprotinin during coronary-artery bypass grafting and risk of death. N Engl J Med. 2008;358(8):771 -783.
18. Barrons RW, Jahr JS. A review ofpost-cardiopulmonary bypass bleeding, aminocaproic acid, tranexamic acid, and aprotinin. Am J Ther. 1996;3(12):821-838.
19. Hardy JF, Desroches J. Natural and synthetic antifibrinolytics in cardiac surgery. Can J Anaesth. 1992;39(4):353-365.
20. Florentino-Pineda I, Blakemore LC, Thompson GH, et al. The effect of epsilon-aminocaproic acid on perioperative blood loss in patients with idiopathic scoliosis undergoing posterior spinal fusion: a preliminary prospective study. Spine. 2001;26(10):1147-1151.
21. Shapiro F, Zurakowski D, Sethna NF. Tranexamic acid diminishes intraoperative blood loss and transfusion in spinal fusions for Duchenne muscular dystrophy scoliosis. Spine. 2007;32(20): 2278-2283.
22. Thompson GH, Florentino-Pineda I, Poe-Kochert C, et al. Role of amicar in surgery for neuromuscular scoliosis. Spine. 2008;33(24): 2623-2629.
23. Thompson GH, Florentino-Pineda I, Poe-Kochert C, et al. The role of amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis. Spine. 2008;33(20):2237-2242.
24. Thompson GH, Florentino-Pineda I, Poe-Kochert C. The role ofamicar in decreasing perioperative blood loss in idiopathic scoliosis. Spine. 2005;30(17):suppl:S94-S99.
25. Dunn CJ, Goa KL. Tranexamic acid: a review of its use in surgery and other indications. Drugs. 1999;57(6):1005-1032.
26. Suk SI, Lee CK, Kim WJ, et al. Segmental pedicle screw fixation in the treatment of thoracic idiopathic scoliosis. Spine. 1995;20(12):1399-1405.
27. Kannan S, Meert KL, Mooney JF, et al. Bleeding and coagulation changes during spinal fusion surgery: a comparison of neuromuscular and idiopathic scoliosis patients. Pediatr Crit Care Med. 2002;3(4):364-369.
28. Saito T, Takenaka M, Miyai I, et al. Coagulation and fibrinolysis disorder in muscular dystrophy. Muscle Nerve. 2001;24(3): 399-402.
29. Meert KL, Kannan S, Mooney JF. Predictors of red cell transfusion in children and adolescents undergoing spinal fusion surgery. Spine. 2002;27(19):2137-2142.