Design and Testing of a Pulsatile Conditioning System for Dynamic Endothelialization of Polyphenol-Stabilized Tissue Engineered Heart Valves

Cardiovascular Engineering and Technology

Volumn 1, Issue 2, 2010, Pages 138-153

  Sierad, Leslie Neil ^a   Simionescu, Agneta ^a   Albers, Christopher ^a   Chen, Joseph ^b   Maivelett, Jordan ^a   Tedder, Mary Elizabeth ^a   Liao, Jun ^b   Simionescu, Dan T ^a  

^a AMRL   (United States)

^b MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Biaxial mechanical testing; Endothelial cells; Scanning electron microscopy; Stabilization; Tissue engineered heart valves

Indexed keywords

AORTIC HEART VALVES; AORTIC ROOT; BIAXIAL MECHANICAL TESTING; BIOREACTOR SYSTEM; CELL COVERAGE; CELL VIABILITY; CHEMICAL EXTRACTIONS; COLLAGENASE; CONDITIONING SYSTEMS; DECELLULARIZED; ELASTASE; ENDOTHELIALIZATION; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX COMPONENTS; HEART VALVES; MECHANICAL ANALYSIS; MECHANICAL FORCE; METABOLIC ACTIVITY; POLYPHENOLS; REPOPULATION; STERILE CONDITIONS; THERMAL DENATURATIONS; TISSUE ENGINEERED HEART VALVES; TISSUE PREPARATION; TISSUE-ENGINEERED HEART; VALVE PRESSURE;

BIOCONVERSION; BIOMECHANICS; BIOREACTORS; BLOOD VESSELS; DYNAMICS; ELECTRON TUBES; ENDOTHELIAL CELLS; GLUCOSE; HEART; MECHANICAL ENGINEERING; MECHANICAL PROPERTIES; MECHANICAL TESTING; PYROLYSIS; SCAFFOLDS (BIOLOGY); SCANNING ELECTRON MICROSCOPY; SELF ASSEMBLY; STABILIZATION; TISSUE;

VALVES (MECHANICAL);

COLLAGENASE; ELASTASE; GLUCOSE PENTAGALLATE; TISSUE SCAFFOLD;

ANIMAL CELL; ANIMAL TISSUE; AORTA ROOT; AORTA VALVE PROSTHESIS; ARTICLE; BIOMECHANICS; BIOREACTOR; BIOREACTOR DESIGN; CELL ACTIVITY; CELL COMPOSITION; CELL INTERACTION; CELL METABOLISM; CELL STRUCTURE; CELL SURVIVAL; CELL TRANSFORMATION; CELL VIABILITY; CONTROLLED STUDY; DYNAMIC ENDOTHELIALIZATION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; LUNG PRESSURE; MATERIALS TESTING; NONHUMAN; PULMONARY VALVE; PULSATILE FLOW; SURVIVAL TIME; SWINE; THERMOSTABILITY; TISSUE ENGINEERING;

EID: 79953200175     PISSN: 1869408X     EISSN: 18694098     Source Type: Journal    
DOI: 10.1007/s13239-010-0014-6     Document Type: Article

References (38)

1. Azimzadeh, A., P. Wolf, K. Thibaudeau, J. Cinqualbre, J. P. Soulillou, and I. Anegon. Comparative study of target antigens for primate xenoreactive natural antibodies in pig and rat endothelial cells. Transplantation 64(8): 1166-1174, 1997.
2. Baraki, H., I. Tudorache, M. Braun, K. Höffler, A. Görler, A. Lichtenberg, C. Bara, A. Calistru, G. Brandes, M. Hewicker-Trautwein, A. Hilfiker, A. Haverich, and S. Cebotari. Orthotopic replacement of the aortic valve with decellularized allograft in a sheep model. Biomaterials 30(31): 6240-6246, 2009.
3. Billiar, K. L., and M. S. Sacks. Biaxial mechanical properties of the natural and glutaraldehyde treated aortic valve cusp. Part I: Experimental results. J. Biomech. Eng. 122(1): 23-30, 2000.
4. Chuang, T. H., C. Stabler, A. Simionescu, and D. T. Simionescu. Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts. Tissue Eng. Part A 15(10): 2837-2851, 2009.
5. Dym, C. L., and P. Little. Engineering Design: A Project-Based Introduction (2nd ed.). John Wiley & Sons, 2004.
6. Flanagan, T. C., C. Cornelissen, S. Koch, B. Tschoeke, J. S. Sachweh, T. Schmitz-Rode, and S. Jockenhoevel. The in vitro development of autologous fibrin-based tissue-engineered heart valves through optimised dynamic conditioning. Biomaterials 28(23): 3388-3397, 2007.
7. Grashow, J. S., A. P. Yoganathan, and M. S. Sacks. Biaxial stress-stretch behavior of the mitral valve anterior leaflet at physiologic strain rates. Ann. Biomed. Eng. 34(2): 315-325, 2006.
8. Hildebrand, D. K., Z. J. Wu, J. E. Mayer, and M. S. Sacks. Design and hydrodynamic evaluation of a novel pulsatile bioreactor for biologically active heart valves. Ann. Biomed. Eng. 32(8): 1039-1049, 2004.
9. Hoerstrup, S. P., R. Sodian, S. Daebritz, J. Wang, E. A. Bacha, D. P. Martin, A. M. Moran, K. J. Guleserian, J. S. Sperling, S. Kaushal, J. P. Vacanti, F. J. Schoen, and J. E. Mayer, Jr. Functional living trileaflet heart valves grown in vitro. Circulation 102(19 Suppl 3): III44-III49, 2000.
10. Hoerstrup, S. P., R. Sodian, J. S. Sperling, J. P. Vacanti, and J. E. Mayer. New pulsatile bioreactor for in vitro formation of tissue engineered heart valves. Tissue Eng. 6(1): 75-79, 2000.
11. Hoerstrup, S. P., G. Zund, A. M. Schnell, S. A. Kolb, J. F. Visjager, A. Schoeberlein, and M. Turina. Optimized growth conditions for tissue engineering of human cardiovascular structures. Int. J. Artif. Organs 23(12): 817-823, 2000.
12. Iop, L., V. Renier, F. Naso, M. Piccoli, A. Bonetti, A. Gandaglia, M. Pozzobon, A. Paolin, F. Ortolani, M. Marchini, M. Spina, P. De Coppi, S. Sartore, and G. Gerosa. The influence of heart valve leaflet matrix characteristics on the interaction between human mesenchymal stem cells and decellularized scaffolds. Biomaterials 30(25): 4104-4116, 2009.
13. Isenburg, J. C., D. T. Simionescu, B. C. Starcher, and N. R. Vyavahare. Elastin stabilization for treatment of abdominal aortic aneurysms. Circulation 115(13): 1729-1737, 2007.
14. Kasimir, M. T., E. Rieder, G. Seebacher, A. Nigisch, B. Dekan, E. Wolner, G. Weigel, and P. Simon. Decellularization does not eliminate thrombogenicity and inflammatory stimulation in tissue-engineered porcine heart valves. J. Heart Valve Dis. 15(2): 278-286, 2006; (discussion 286).
15. Kasimir, M. T., E. Rieder, G. Seebacher, G. Silberhumer, E. Wolner, G. Weigel, and P. Simon. Comparison of different decellularization procedures of porcine heart valves. Int. J. Artif. Organs 26(5): 421-427, 2003.
16. Ku, C. H., P. H. Johnson, P. Batten, P. Sarathchandra, R. C. Chambers, P. M. Taylor, M. H. Yacoub, and A. H. Chester. Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch. Cardiovasc. Res. 71(3): 548-556, 2006.
17. Lee, D. J., J. Steen, J. E. Jordan, E. H. Kincaid, N. D. Kon, A. Atala, J. Berry, and J. J. Yoo. Endothelialization of heart valve matrix using a computer-assisted pulsatile bioreactor. Tissue Eng. Part A 15(4): 807-814, 2009.
18. Liao, J., E. M. Joyce, and M. S. Sacks. Effects of decellularization on mechanical and structural properties of the porcine aortic valve leaflets. Biomaterials 29(8): 1065-1074, 2008.
19. Lichtenberg, A., S. Cebotari, I. Tudorache, G. Sturz, M. Winterhalter, A. Hilfiker, and A. Haverich. Flow-dependent re-endothelialization of tissue-engineered heart valves. J. Heart Valve Dis. 15(2): 287-293, 2006; (discussion 293-284).
20. Lichtenberg, A., I. Tudorache, S. Cebotari, S. Ringes-Lichtenberg, G. Sturz, K. Hoeffler, C. Hurscheler, G. Brandes, A. Hilfiker, and A. Haverich. In vitro re-endothelialization of detergent decellularized heart valves under simulated physiological dynamic conditions. Biomaterials 27(23): 4221-4229, 2006.
21. Mendelson, K., E. Aikawa, B. A. Mettler, V. Sales, D. Martin, J. E. Mayer, and F. J. Schoen. Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep. Cardiovasc. Pathol. 16(5): 277-282, 2007.
22. Mendelson, K., and F. J. Schoen. Heart valve tissue engineering: concepts, approaches, progress, and challenges. Ann. Biomed. Eng. 34(12): 1799-1819, 2006.
23. Merryman, W. D., J. G. C. Engelmayr, J. Liao, and M. S. Sacks. Defining biomechanical endpoints for tissue engineered heart valve leaflets from native leaflet properties. Tissue Bio-Eng. Congenit. Cardiac Dis. 21(2): 153-160, 2006.
24. Mikos, A. G., S. W. Herring, P. Ochareon, J. Elisseeff, H. H. Lu, R. Kandel, F. J. Schoen, M. Toner, D. Mooney, A. Atala, M. E. van Dyke, D. Kaplan, and G. Vunjak-Novakovic. Engineering complex tissues. Tissue Eng. 12(12): 3307-3339, 2006.
25. Mol, A., N. Driessen, M. Rutten, S. Hoerstrup, C. Bouten, and F. Baaijens. Tissue engineering of human heart valve leaflets: a novel bioreactor for a strain-based conditioning approach. Ann. Biomed. Eng. 33(12): 1778-1788, 2005.
26. Ruel, J., and G. Lachance. A new bioreactor for the development of tissue-engineered heart valves. Ann. Biomed. Eng. 37(4): 674-681, 2009.
27. Sacks, M. S., and C. J. Chuong. Biaxial mechanical properties of passive right ventricular free wall myocardium. J. Biomech. Eng. 115: 202-205, 1992.
28. Schenke-Layland, K., F. Opitz, M. Gross, C. Doring, K. J. Halbhuber, F. Schirrmeister, T. Wahlers, and U. A. Stock. Complete dynamic repopulation of decellularized heart valves by application of defined physical signals-an in vitro study. Cardiovasc. Res. 60(3): 497-509, 2003.
29. Schmidt, D., and S. P. Hoerstrup. Tissue engineered heart valves based on human cells. Swiss Med. Wkly 136(39-40): 618-623, 2006.
30. Schmidt, D., and S. P. Hoerstrup. Tissue engineered heart valves based on human cells. Swiss Med. Wkly 137(Suppl 155): 80S-85S, 2007.
31. Schoen, F. J. Evolving concepts of cardiac valve dynamics: the continuum of development, functional structure, pathobiology, and tissue engineering. Circulation 118(18): 1864-1880, 2008.
32. Simon, P., M. T. Kasimir, G. Seebacher, G. Weigel, R. Ullrich, U. Salzer-Muhar, E. Rieder, and E. Wolner. Early failure of the tissue engineered porcine heart valve SYNERGRAFT in pediatric patients. Eur. J. Cardiothorac. Surg. 23(6): 1002-1006, 2003; (discussion 1006).
33. Strokan, V., J. Molne, C. T. Svalander, and M. E. Breimer. Heterogeneous expression of Gal alpha1-3Gal xenoantigen in pig kidney: a lectin and immunogold electron microscopic study. Transplantation 66(11): 1495-1503, 1998.
34. Tedder, M. E., J. Liao, B. Weed, C. Stabler, H. Zhang, A. Simionescu, and D. T. Simionescu. Stabilized collagen scaffolds for heart valve tissue engineering. Tissue Eng. Part A 15(6): 1257-1268, 2009.
35. Valente, M., M. Minarini, A. F. Maizza, U. Bortolotti, and G. Thiene. Heart valve bioprosthesis durability: a challenge to the new generation of porcine valves. Eur. J. Cardiothorac. Surg. 6(Suppl 1): S82-S90, 1992.
36. Zeltinger, J., L. K. Landeen, H. G. Alexander, I. D. Kidd, and B. Sibanda. Development and characterization of tissue-engineered aortic valves. Tissue Eng. 7(1): 9-22, 2001.
37. Zhai, W., J. Chang, K. Lin, J. Wang, Q. Zhao, and X. Sun. Crosslinking of decellularized porcine heart valve matrix by procyanidins. Biomaterials 27(19): 3684-3690, 2006.
38. Zhai, W., X. Lü, J. Chang, Y. Zhou, and H. Zhang. Quercetin-crosslinked porcine heart valve matrix: mechanical properties, stability, anticalcification and cytocompatibility. Acta Biomater. 6(2): 389-395, 2010.