Bivalent bendamustine and melphalan derivatives as anticancer agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1604-1615

  Scutaru, Ana Maria ^a   Wenzel, Maxi ^a   Gust, Ronald ^a,b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Bendamustine; Breast cancer; Dimer; Drug targeting; Melphalan

Indexed keywords

1,6 HEXANEDIAMINE; 1,7 DIAMINOHEPTANE; 1,8 OCTANEDIAMINE; ANTINEOPLASTIC AGENT; BENDAMUSTINE; CISPLATIN; DIAMINE; DODECANE; MALEIMIDE DERIVATIVE; MELPHALAN; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 3 [4 [BIS[2 CHLOROETHYL]AMINO]PHENYL] 2 (TERT BUTOXYCARBONYLAMINO)PROPANOATE] 3 YL] 1,12 DIAMINOOCTANE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 3 [4 [BIS[2 CHLOROETHYL]AMINO]PHENYL] 2 (TERT BUTOXYCARBONYLAMINO)PROPANOATE] 3 YL] 1,7 DIAMINOHEPTANE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 3 [4 [BIS[2 CHLOROETHYL]AMINO]PHENYL] 2 (TERT BUTOXYCARBONYLAMINO)PROPANOATE] 3 YL] 1,7 DIAMINOOCTANE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 3 [4 [BIS[2 CHLOROETHYL]AMINO]PHENYL] 2 PROPANOATE] 3 YL] 1,6 DIAMINODODECENE DIHYDROCHLORIDE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 3 [4 [BIS[2 CHLOROETHYL]AMINO]PHENYL] 2 PROPANOATE] 3 YL] 1,6 DIAMINOHEPTANE DIHYDROCHLORIDE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 3 [4 [BIS[2 CHLOROETHYL]AMINO]PHENYL] 2 PROPANOATE] 3 YL] 1,6 DIAMINOHEXANE DIHYDROCHLORIDE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 4 [5 [BIS[2 CHLOROETHYL]AMINO] 1 METHYL 1H BENZO[D]IMIDAZOL 2 YL]BUTANOATE] 3 YL]1,12 DIAMINOOCTANE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 4 [5 [BIS[2 CHLOROETHYL]AMINO] 1 METHYL 1H BENZO[D]IMIDAZOL 2 YL]BUTANOATE] 3 YL]1,6 DIAMINOHEPTANE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 4 [5 [BIS[2 CHLOROETHYL]AMINO] 1 METHYL 1H BENZO[D]IMIDAZOL 2 YL]BUTANOATE] 3 YL]1,6 DIAMINOHEXANE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 4 [5 [BIS[2 CHLOROETHYL]AMINO] 1 METHYL 1H BENZO[D]IMIDAZOL 2 YL]BUTANOATE] 3 YL]1,8 DIAMINOOCTANE; N,N' BIS[[2 (2,5 DIOXOPYRROLIDIN 1 YL)ETHYL 4 [5 [BIS[2 CHLOROETHYL]AMINO]PHENYL] 2 (TERT BUTOXYCARBONYLAMINO)PROPANOATE] 3 YL]1,6 DIAMINOHEXANE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MELPHALAN; MOLECULAR STRUCTURE; NITROGEN MUSTARD COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 79953193744     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.008     Document Type: Article

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