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Volumn 68, Issue 18, 2008, Pages 2645-2660

Bendamustine: A review of its use in the management of indolent non-hodgkin lymphoma

Author keywords

Adis drug evaluations; Bendamustine, general; Non hodgkin's lymphoma

Indexed keywords

BENDAMUSTINE; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; DOXORUBICIN; MELPHALAN; PHOSPHORAMIDE MUSTARD; PREDNISONE; RITUXIMAB; VINCRISTINE;

EID: 57749198030     PISSN: 00126667     EISSN: 00126667     Source Type: Journal    
DOI: 10.2165/0003495-200868180-00009     Document Type: Review
Times cited : (14)

References (36)
  • 1
    • 57749185939 scopus 로고    scopus 로고
    • version [online, Available from URL:, Accessed 2008 Oct 6
    • National Cancer Institute. Adult non-Hodgkin lymphoma treatment (PDQ®): health professional version [online]. Available from URL: http://www.cancer.gov/cancertopics/pdq/treatment/adult-non-hodgkins [Accessed 2008 Oct 6]
    • Adult non-Hodgkin lymphoma treatment (PDQ®): Health professional
  • 3
    • 16244403039 scopus 로고    scopus 로고
    • Cancer incidence and mortality in Europe, 2004
    • Boyle P, Ferlay J. Cancer incidence and mortality in Europe, 2004. Ann Oncol 2005; 16: 481-8
    • (2005) Ann Oncol , vol.16 , pp. 481-488
    • Boyle, P.1    Ferlay, J.2
  • 4
    • 57749198285 scopus 로고    scopus 로고
    • Detailed guide: Lymphoma, non-Hodgkin type
    • online, Available from URL:, Accessed 2008 Oct 6
    • American Cancer Society. Detailed guide: lymphoma, non-Hodgkin type. What is non-Hodgkin lymphoma? [online]. Available from URL: http://www.cancer.org/ docroot/CRI/content [Accessed 2008 Oct 6]
    • What is non-Hodgkin lymphoma
  • 6
    • 57749200329 scopus 로고    scopus 로고
    • Cephalon. Cephalon receives FDA approval for Treanda® to treat patients with relapsed indolent non-Hodgkin's lymphoma [media release]. 2008 Oct 31 [online]. Available from URL: http://www.cephalon.com/media/news-releases/ [Accessed 2008 Nov 4]
    • Cephalon. Cephalon receives FDA approval for Treanda® to treat patients with relapsed indolent non-Hodgkin's lymphoma [media release]. 2008 Oct 31 [online]. Available from URL: http://www.cephalon.com/media/news-releases/ [Accessed 2008 Nov 4]
  • 7
    • 57749207537 scopus 로고    scopus 로고
    • Treanda® (bendamustine hydrochloride for injection) for intravenous infusion: US prescribing information
    • Cephalon, Inc, PA, Oct
    • Cephalon, Inc. Treanda® (bendamustine hydrochloride for injection) for intravenous infusion: US prescribing information. Cephalon, Inc: Frazer (PA), 2008 Oct
    • (2008) Cephalon, Inc: Frazer
  • 8
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda®) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • Jan 1;
    • Leoni LM, Bailey B, Reifert J, et al. Bendamustine (Treanda®) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res 2008 Jan 1; 14 (1): 309-17
    • (2008) Clin Cancer Res , vol.14 , Issue.1 , pp. 309-317
    • Leoni, L.M.1    Bailey, B.2    Reifert, J.3
  • 9
    • 38849098573 scopus 로고    scopus 로고
    • Forero-Torres A, Saleh MN. Bendamustine in non-Hodgkin lymphoma: the double-agent that came from the cold war. Clin Lymphoma Myeloma 2007 Dec; 8 Suppl. 1: S13-7
    • Forero-Torres A, Saleh MN. Bendamustine in non-Hodgkin lymphoma: the double-agent that came from the cold war. Clin Lymphoma Myeloma 2007 Dec; 8 Suppl. 1: S13-7
  • 10
    • 0036340122 scopus 로고    scopus 로고
    • Metabolism and mechanisms of action of bendamustine: Rationales for combination therapies
    • Aug;
    • Gandhi V. Metabolism and mechanisms of action of bendamustine: rationales for combination therapies. Semin Oncol 2002 Aug; 29 (4 Suppl. 13): 4-11
    • (2002) Semin Oncol , vol.29 , Issue.4 SUPPL. 13 , pp. 4-11
    • Gandhi, V.1
  • 11
    • 57749205026 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Non-Hodgkin's Lymphomas (V.3.2008). 2008 Apr 10
    • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Non-Hodgkin's Lymphomas (V.3.2008). 2008 Apr 10
  • 12
    • 0030005440 scopus 로고    scopus 로고
    • Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines
    • Jun;
    • Strumberg D, Harstrick A, Doll K, et al. Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines. Anticancer Drugs 1996 Jun; 7 (4): 415-21
    • (1996) Anticancer Drugs , vol.7 , Issue.4 , pp. 415-421
    • Strumberg, D.1    Harstrick, A.2    Doll, K.3
  • 13
    • 2642536197 scopus 로고    scopus 로고
    • Alkylating DNA damage stimulates a regulated form of necrotic cell death
    • Zong W-X, Ditsworth D, Bauer DE, et al. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 2004; 18: 1272-82
    • (2004) Genes Dev , vol.18 , pp. 1272-1282
    • Zong, W.-X.1    Ditsworth, D.2    Bauer, D.E.3
  • 14
    • 0001112685 scopus 로고    scopus 로고
    • Bendamustin in induction of apoptosis in B-cell chronic lymphocytic leukemia [abstract no. 478]
    • Schwaenen C, Karakas T, Schrader M, et al. Bendamustin in induction of apoptosis in B-cell chronic lymphocytic leukemia [abstract no. 478]. Ann Oncol 1999; 10 Suppl. 3: 132
    • (1999) Ann Oncol , vol.10 , Issue.SUPPL. 3 , pp. 132
    • Schwaenen, C.1    Karakas, T.2    Schrader, M.3
  • 15
    • 0035351214 scopus 로고    scopus 로고
    • In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine
    • May;
    • Chow KU, Boehrer S, Geduldig K, et al. In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine. Haematologica 2001 May; 86 (5): 485-93
    • (2001) Haematologica , vol.86 , Issue.5 , pp. 485-493
    • Chow, K.U.1    Boehrer, S.2    Geduldig, K.3
  • 16
    • 0041930595 scopus 로고    scopus 로고
    • Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation
    • Chow KU, Nowak D, Boehrer S, et al. Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochem Pharmacol 2003; 66: 711-24
    • (2003) Biochem Pharmacol , vol.66 , pp. 711-724
    • Chow, K.U.1    Nowak, D.2    Boehrer, S.3
  • 17
    • 2542616681 scopus 로고    scopus 로고
    • Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus
    • Jul;
    • Nowak D, Boehrer S, Brieger A, et al. Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus. Leuk Lymphoma 2004 Jul; 45 (7): 1429-36
    • (2004) Leuk Lymphoma , vol.45 , Issue.7 , pp. 1429-1436
    • Nowak, D.1    Boehrer, S.2    Brieger, A.3
  • 18
    • 0036154263 scopus 로고    scopus 로고
    • Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: Role of cytokines, complement, and caspases
    • Chow KU, Sommerlad WD, Boehrer S, et al. Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases. Haematologica 2002; 87: 33-43
    • (2002) Haematologica , vol.87 , pp. 33-43
    • Chow, K.U.1    Sommerlad, W.D.2    Boehrer, S.3
  • 19
    • 34247093863 scopus 로고    scopus 로고
    • A phase I study of bendamustine hydrochloride administered once every 3 weeks in patients with solid tumors
    • Rasschaert M, Schrijvers D, Van den Brande J, et al. A phase I study of bendamustine hydrochloride administered once every 3 weeks in patients with solid tumors. Anticancer Drugs 2007; 18: 587-95
    • (2007) Anticancer Drugs , vol.18 , pp. 587-595
    • Rasschaert, M.1    Schrijvers, D.2    Van den Brande, J.3
  • 20
    • 34249795785 scopus 로고    scopus 로고
    • A phase I study of bendamustine hydrochloride administered day 1 + 2 every 3 weeks in patients with solid tumours
    • Rasschaert M, Schrijvers D, Van den Brande J. A phase I study of bendamustine hydrochloride administered day 1 + 2 every 3 weeks in patients with solid tumours. Br J Cancer 2007; 96: 1692-8
    • (2007) Br J Cancer , vol.96 , pp. 1692-1698
    • Rasschaert, M.1    Schrijvers, D.2    Van den Brande, J.3
  • 21
    • 0022372504 scopus 로고
    • Pharmacokinetics of bendamustine (Cytostasane) in patients
    • in German
    • Preiss R, Sohr R, Matthias M, et al. Pharmacokinetics of bendamustine (Cytostasane) in patients [in German]. Pharmazie 1985; 40 (11): 782-4
    • (1985) Pharmazie , vol.40 , Issue.11 , pp. 782-784
    • Preiss, R.1    Sohr, R.2    Matthias, M.3
  • 23
    • 33947305075 scopus 로고    scopus 로고
    • Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride
    • Teichert J, Baumann F, Chao Q, et al. Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride. Cancer Chemother Pharmacol 2007; 59: 759-70
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 759-770
    • Teichert, J.1    Baumann, F.2    Chao, Q.3
  • 24
    • 22344452534 scopus 로고    scopus 로고
    • Synthesis and characterization of some new phase II metabolites of the alkylator bendamustine and their identification in human bile, urine and plasma from patients with cholangiocarcinoma
    • Teichert J, Sohr R, Baumann F, et al. Synthesis and characterization of some new phase II metabolites of the alkylator bendamustine and their identification in human bile, urine and plasma from patients with cholangiocarcinoma. Drug Metab Dispos 2005; 33 (7): 984-92
    • (2005) Drug Metab Dispos , vol.33 , Issue.7 , pp. 984-992
    • Teichert, J.1    Sohr, R.2    Baumann, F.3
  • 25
    • 41349109244 scopus 로고    scopus 로고
    • Bendamustine plus rituximab versus CHOP plus rituximab in the first-line treatment of patients with indolent and mantle cell lymphomas: First interim results of a randomized phase III study of the StiL (Study Group Indolent Lymphomas, Germany) [abstract no. 385]
    • Nov 16;
    • Rummel MJ, von Gruenhagen U, Niederle N, et al. Bendamustine plus rituximab versus CHOP plus rituximab in the first-line treatment of patients with indolent and mantle cell lymphomas: first interim results of a randomized phase III study of the StiL (Study Group Indolent Lymphomas, Germany) [abstract no. 385]. Blood 2007 Nov 16; 110 (11 Pt 1): 120a
    • (2007) Blood , vol.110 , Issue.11 PART 1
    • Rummel, M.J.1    von Gruenhagen, U.2    Niederle, N.3
  • 26
    • 33646986211 scopus 로고    scopus 로고
    • Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: Results of a randomised phase III trial (OSHO# 19)
    • Feb;
    • Herold M, Schulze A, Niederwieser D, et al. Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: results of a randomised phase III trial (OSHO# 19). J Cancer Res Clin Oncol 2006 Feb; 132 (2): 105-12
    • (2006) J Cancer Res Clin Oncol , vol.132 , Issue.2 , pp. 105-112
    • Herold, M.1    Schulze, A.2    Niederwieser, D.3
  • 27
    • 57749185082 scopus 로고    scopus 로고
    • Kahl B, Bartlett NL, Leonard JP. Bendamustine is safe and effective in patients with rituximab-refractory, indolent B-cell non-Hodgkins lymphoma [abstract no. 1351]. Blood 2007; 110 (11 Pt 1): 406a. Plus poster presented at the 49th Annual Metting of the American Society of Hematology; 2007 Dec 8-11; Atlanta (GA)
    • Kahl B, Bartlett NL, Leonard JP. Bendamustine is safe and effective in patients with rituximab-refractory, indolent B-cell non-Hodgkins lymphoma [abstract no. 1351]. Blood 2007; 110 (11 Pt 1): 406a. Plus poster presented at the 49th Annual Metting of the American Society of Hematology; 2007 Dec 8-11; Atlanta (GA)
  • 28
    • 52649177173 scopus 로고    scopus 로고
    • Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma
    • Sep 20;
    • Robinson KS, Williams ME, van der Jagt RH, et al. Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma. J Clin Oncol 2008 Sep 20; 26 (27): 4473-9
    • (2008) J Clin Oncol , vol.26 , Issue.27 , pp. 4473-4479
    • Robinson, K.S.1    Williams, M.E.2    van der Jagt, R.H.3
  • 29
    • 0034773457 scopus 로고    scopus 로고
    • Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas
    • Oct;
    • Heider A, Niederle N. Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas. Anticancer Drugs 2001 Oct; 12 (9): 725-9
    • (2001) Anticancer Drugs , vol.12 , Issue.9 , pp. 725-729
    • Heider, A.1    Niederle, N.2
  • 30
    • 20644469242 scopus 로고    scopus 로고
    • Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma
    • May 20;
    • Rummel MJ, Al-Batran SE, Kim SZ, et al. Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma. J Clin Oncol 2005 May 20; 23 (15): 3383-9
    • (2005) J Clin Oncol , vol.23 , Issue.15 , pp. 3383-3389
    • Rummel, M.J.1    Al-Batran, S.E.2    Kim, S.Z.3
  • 31
    • 57749194024 scopus 로고    scopus 로고
    • Friedberg JW, Cohen P, Chen L, et al. Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: results from a phase II multicenter, single-agent study [published erratum appears in J Clin Oncol 2008 Apr 10; 26 (11): 1911]. J Clin Oncol 2008 Jan 10; 26 (2): 204-10
    • Friedberg JW, Cohen P, Chen L, et al. Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: results from a phase II multicenter, single-agent study [published erratum appears in J Clin Oncol 2008 Apr 10; 26 (11): 1911]. J Clin Oncol 2008 Jan 10; 26 (2): 204-10
  • 32
    • 74549215880 scopus 로고    scopus 로고
    • Efficacy and safety of bendamustine and rituximab in the treatment of indolent and mantle cell lymphomas in older patients [abstract no. 8572]
    • May 20;, 472s
    • Rummel MJ, Heine K, Bodenstein H, et al. Efficacy and safety of bendamustine and rituximab in the treatment of indolent and mantle cell lymphomas in older patients [abstract no. 8572]. J Clin Oncol 2008 May 20; 26 Suppl.: 472s
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Rummel, M.J.1    Heine, K.2    Bodenstein, H.3
  • 33
    • 0036449340 scopus 로고    scopus 로고
    • High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's-lymphomas
    • Nov;
    • Bremer K. High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's-lymphomas. J Cancer Res Clin Oncol 2002 Nov; 128 (11): 603-9
    • (2002) J Cancer Res Clin Oncol , vol.128 , Issue.11 , pp. 603-609
    • Bremer, K.1
  • 34
    • 0030808228 scopus 로고    scopus 로고
    • Bendamustin as second-line therapy in patients with relapsed low grade non-Hodgkin's lymphoma and multiple myeloma
    • in German
    • Heider A, Kress M, Niederle N. Bendamustin as second-line therapy in patients with relapsed low grade non-Hodgkin's lymphoma and multiple myeloma [in German]. Tumor Diagnostik Und Therapie 1997; 18 (3): 71-5
    • (1997) Tumor Diagnostik Und Therapie , vol.18 , Issue.3 , pp. 71-75
    • Heider, A.1    Kress, M.2    Niederle, N.3
  • 35
    • 70349354172 scopus 로고    scopus 로고
    • Bendamustine plus rituximab versus CHOP plus rituximab in the first-line-treatment of patients with Waldenström's disease: First interim results of a randomized phase III study of the Studygroup Indolent Lymhomas (StiL)
    • abstract no. 139, Oct 15-19; Stockholm
    • Rummel MJ, von Gruenhagen U, Cottbus P, et al. Bendamustine plus rituximab versus CHOP plus rituximab in the first-line-treatment of patients with Waldenström's disease: first interim results of a randomized phase III study of the Studygroup Indolent Lymhomas (StiL) [abstract no. 139]. 5th International Workshop on Waldenström's Macroglobulinemia; 2008 Oct 15-19; Stockholm
    • (2008) 5th International Workshop on Waldenström's Macroglobulinemia
    • Rummel, M.J.1    von Gruenhagen, U.2    Cottbus, P.3
  • 36
    • 14544276412 scopus 로고    scopus 로고
    • Maximizing therapeutic benefit of rituximab: Maintenance therapy versus retreatment at progression in patients with indolent non-Hodgkin's lymphoma: a randomized phase II trial of the Minnie Pearl Cancer Research Network
    • Feb 20;
    • Hainsworth JD, Litchy S, Shaffer DW, et al. Maximizing therapeutic benefit of rituximab: maintenance therapy versus retreatment at progression in patients with indolent non-Hodgkin's lymphoma: a randomized phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol 2005 Feb 20; 23 (6): 1088-95
    • (2005) J Clin Oncol , vol.23 , Issue.6 , pp. 1088-1095
    • Hainsworth, J.D.1    Litchy, S.2    Shaffer, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.