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Volumn 12, Issue 5, 2008, Pages 799-806

Bendamustine: A novel cytotoxic agent for hematologic malignancies

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENDAMUSTINE; CHLORMETHINE DERIVATIVE;

EID: 58149280526     PISSN: 10921095     EISSN: 1538067X     Source Type: Journal    
DOI: 10.1188/08.CJON.799-806     Document Type: Article
Times cited : (15)

References (48)
  • 1
    • 0036337956 scopus 로고    scopus 로고
    • Bendamustine in the treatment of chronic lymphocytic leukemia: Results and future perspectives
    • Aivado, M., Schulte, K., Henze, L., Burger, J., Finke, J., & Haas, R. (2002). Bendamustine in the treatment of chronic lymphocytic leukemia: Results and future perspectives. Seminars in Oncology, 29 (4, Suppl. 3), 19-22.
    • (2002) Seminars in Oncology , vol.29 , Issue.4 SUPPL. 3 , pp. 19-22
    • Aivado, M.1    Schulte, K.2    Henze, L.3    Burger, J.4    Finke, J.5    Haas, R.6
  • 2
    • 17944391542 scopus 로고
    • Treatment of multiple myeloma with a new cytostatic agent: Gamma-1-methyl-5-bis- (beta-chlorethyl) -amino-benzimidazolyl (2) butyric acid hydrochloride
    • Anger, G., Hesse, P., & Baufeld, H. (1969). Treatment of multiple myeloma with a new cytostatic agent: Gamma-1-methyl-5-bis- (beta-chlorethyl) -amino-benzimidazolyl (2) -butyric acid hydrochloride. Deutsche Medizinische Wochenschrift, 94(48), 2495-2500.
    • (1969) Deutsche Medizinische Wochenschrift , vol.94 , Issue.48 , pp. 2495-2500
    • Anger, G.1    Hesse, P.2    Baufeld, H.3
  • 3
    • 23244462775 scopus 로고    scopus 로고
    • Non-Hodgkin lymphoma: Diagnosis and treatment
    • Ansell, S.M., & Armitage, J. (2005). Non-Hodgkin lymphoma: Diagnosis and treatment. Mayo Clinic Proceedings, 80(8), 1087-1097.
    • (2005) Mayo Clinic Proceedings , vol.80 , Issue.8 , pp. 1087-1097
    • Ansell, S.M.1    Armitage, J.2
  • 4
    • 27144548424 scopus 로고    scopus 로고
    • Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase I/II study of the German CLL Study Group
    • Bergmann, M.A., Goebeler, M.E., Herold, M., Emmerich, B., Wilhelm, M., Ruelfs, C., et al. (2005). Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase I/II study of the German CLL Study Group. Haematologica, 90(10), 1357-1364.
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1357-1364
    • Bergmann, M.A.1    Goebeler, M.E.2    Herold, M.3    Emmerich, B.4    Wilhelm, M.5    Ruelfs, C.6
  • 5
    • 0036449340 scopus 로고    scopus 로고
    • High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's-lymphomas
    • Bremer, K. (2002). High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's-lymphomas. Journal of Cancer Research and Clinical Oncology, 128(11), 603-609.
    • (2002) Journal of Cancer Research and Clinical Oncology , vol.128 , Issue.11 , pp. 603-609
    • Bremer, K.1
  • 9
    • 0035351214 scopus 로고    scopus 로고
    • In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine
    • Chow, K.U., Boehrer, S., Geduldig, K., Krapohl, A., Hoelzer, D., Mitrou, P.S., et al. (2001). In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine. Haematologica, 86(5), 485-493.
    • (2001) Haematologica , vol.86 , Issue.5 , pp. 485-493
    • Chow, K.U.1    Boehrer, S.2    Geduldig, K.3    Krapohl, A.4    Hoelzer, D.5    Mitrou, P.S.6
  • 10
    • 34249725061 scopus 로고    scopus 로고
    • Radioimmunotherapy for B-cell lymphoma: Y90 ibritumomab tiuxetan and I(131) tositumomab
    • Davies, A.J. (2007). Radioimmunotherapy for B-cell lymphoma: Y90 ibritumomab tiuxetan and I(131) tositumomab. Oncogene, 26(25), 3614-3628.
    • (2007) Oncogene , vol.26 , Issue.25 , pp. 3614-3628
    • Davies, A.J.1
  • 11
    • 34547668529 scopus 로고    scopus 로고
    • Weekly administration of bendamustine as salvage therapy in metastatic breast cancer: Final results of a phase II study
    • Eichbaum, M.H., Schuetz, F., Khbeis, T., Lauschner, I., Foerster, F., Sohn, C., et al. (2007). Weekly administration of bendamustine as salvage therapy in metastatic breast cancer: Final results of a phase II study. Anti-Cancer Drugs, 18(8), 963-968.
    • (2007) Anti-Cancer Drugs , vol.18 , Issue.8 , pp. 963-968
    • Eichbaum, M.H.1    Schuetz, F.2    Khbeis, T.3    Lauschner, I.4    Foerster, F.5    Sohn, C.6
  • 12
    • 9744237937 scopus 로고    scopus 로고
    • Radioimmunotherapy for non-Hodgkin's lymphoma
    • Friedberg, J.W. (2004). Radioimmunotherapy for non-Hodgkin's lymphoma. Clinical Cancer Research, 10(23), 7789-7791.
    • (2004) Clinical Cancer Research , vol.10 , Issue.23 , pp. 7789-7791
    • Friedberg, J.W.1
  • 13
    • 38349119981 scopus 로고    scopus 로고
    • Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: Results from a phase II multicenter, single-agent study
    • Friedberg, J.W., Cohen, P., Chen, L., Robinson, K.S., Forero-Torres, A., La Casce, A.S., et al. (2008). Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: Results from a phase II multicenter, single-agent study. Journal of Clinical Oncology, 26(2), 204-210.
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.2 , pp. 204-210
    • Friedberg, J.W.1    Cohen, P.2    Chen, L.3    Robinson, K.S.4    Forero-Torres, A.5    la Casce, A.S.6
  • 14
    • 33744802581 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia (CLL): First-line treatment
    • Hallek, M. (2005). Chronic lymphocytic leukemia (CLL): First-line treatment. Hematology, 285-291.
    • (2005) Hematology , pp. 285-291
    • Hallek, M.1
  • 15
    • 0024991018 scopus 로고
    • Untersuchungen zur plasmaciweibindung von bendamustin (Cytostasan) and Ambazon
    • Hasse, D., Priess, R., & Sohr, R. (1990). Untersuchungen zur plasmaciweibindung von bendamustin (Cytostasan) and Ambazon. Zeitschrift für klinische Medizin, 45, 1267-1272.
    • (1990) Zeitschrift Für Klinische Medizin , vol.45 , pp. 1267-1272
    • Hasse, D.1    Priess, R.2    Sohr, R.3
  • 16
    • 0034773457 scopus 로고    scopus 로고
    • Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas
    • Heider, A., & Niederle, N. (2001). Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas. Anti-Cancer Drugs, 12(9), 725-729.
    • (2001) Anti-Cancer Drugs , vol.12 , Issue.9 , pp. 725-729
    • Heider, A.1    Niederle, N.2
  • 17
    • 33646986211 scopus 로고    scopus 로고
    • Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: Results of a randomised phase III trial (OSHO# 19)
    • Herold, M., Schulze, A., Niederwieser, D., Franke, A., Fricke, H.J., Richter, P., et al. (2006). Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: Results of a randomised phase III trial (OSHO# 19). Journal of Cancer Research and Clinical Oncology, 132(2), 105-112.
    • (2006) Journal of Cancer Research and Clinical Oncology , vol.132 , Issue.2 , pp. 105-112
    • Herold, M.1    Schulze, A.2    Niederwieser, D.3    Franke, A.4    Fricke, H.J.5    Richter, P.6
  • 21
    • 64249163652 scopus 로고    scopus 로고
    • SDX-105 (Treanda) enhances the tumor growth inhibitory effect of rituximab in Daudi lymphoma xenografts [Abstract]
    • Kanekal, S., Crain, B., & Elliott, G. (2004). SDX-105 (Treanda) enhances the tumor growth inhibitory effect of rituximab in Daudi lymphoma xenografts [Abstract]. ASH Annual Meeting Abstracts, 104, 4580.
    • (2004) ASH Annual Meeting Abstracts , vol.104 , pp. 4580
    • Kanekal, S.1    Crain, B.2    Elliott, G.3
  • 24
    • 25444512381 scopus 로고    scopus 로고
    • The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy
    • Knop, S., Straka, C., Haen, M., Schwedes, R., Hebart, H., & Einsele, H. (2005). The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy. Haematologica, 90(9), 1287-1288.
    • (2005) Haematologica , vol.90 , Issue.9 , pp. 1287-1288
    • Knop, S.1    Straka, C.2    Haen, M.3    Schwedes, R.4    Hebart, H.5    Einsele, H.6
  • 26
    • 11144357625 scopus 로고    scopus 로고
    • Bendamustine plus mitoxantrone-A new effective treatment for advanced chronic lymphocytic leukaemia: Results of a phase I/II study
    • Koppler, H., Heymanns, J., Pandorf, A., & Weide, R. (2004). Bendamustine plus mitoxantrone-A new effective treatment for advanced chronic lymphocytic leukaemia: Results of a phase I/II study. Leukemia and Lymphoma, 45(5), 911-913.
    • (2004) Leukemia and Lymphoma , vol.45 , Issue.5 , pp. 911-913
    • Koppler, H.1    Heymanns, J.2    Pandorf, A.3    Weide, R.4
  • 29
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • Leoni, L.M., Bailey, B., Reifert, J., Bendall, H.H., Zeller, R.W., Corbeil, J., et al. (2008). Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clinical Cancer Research, 14(1), 309-317.
    • (2008) Clinical Cancer Research , vol.14 , Issue.1 , pp. 309-317
    • Leoni, L.M.1    Bailey, B.2    Reifert, J.3    Bendall, H.H.4    Zeller, R.W.5    Corbeil, J.6
  • 30
    • 28644433498 scopus 로고    scopus 로고
    • Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy
    • Lissitchkov, T., Arnaudov, G., Peytchev, D., & Merkle, K. (2006). Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy. Journal of Cancer Research and Clinical Oncology, 132(2), 99-104.
    • (2006) Journal of Cancer Research and Clinical Oncology , vol.132 , Issue.2 , pp. 99-104
    • Lissitchkov, T.1    Arnaudov, G.2    Peytchev, D.3    Merkle, K.4
  • 31
    • 33646783722 scopus 로고    scopus 로고
    • National Cancer Institute, January 8, 2008
    • National Cancer Institute. (2006). Common terminology criteria for adverse events [v.3.0]. Retrieved January 8, 2008, from http://ctep.cancer.gov/forms/CTCAEv3.pdf
    • (2006) Common Terminology Criteria For Adverse Events [v.3.0]
  • 35
    • 64249170013 scopus 로고    scopus 로고
    • Population pharmacokinetics of bendamustine and metabolites in patients with indolent non-Hodgkin's lymphoma (NHL)
    • Owen, J.S., Melhem, M., D'Andrea, D., & Darwish, M. (2008). Population pharmacokinetics of bendamustine and metabolites in patients with indolent non-Hodgkin's lymphoma (NHL). Pharmacology and Therapeutics, 83(Suppl. 1), S54.
    • (2008) Pharmacology and Therapeutics , vol.83 , Issue.SUPPL. 1
    • Owen, J.S.1    Melhem, M.2    D'andrea, D.3    Darwish, M.4
  • 36
    • 31344443373 scopus 로고    scopus 로고
    • Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone-A randomized phase III study of the East German Study Group of Hematology and Oncology (OSHO)
    • Ponisch, W., Mitrou, P.S., Merkle, K., Herold, M., Assmann, M., Wilhelm, G., et al. (2006). Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone-A randomized phase III study of the East German Study Group of Hematology and Oncology (OSHO). Journal of Cancer Research and Clinical Oncology, 132(4), 205-212.
    • (2006) Journal of Cancer Research and Clinical Oncology , vol.132 , Issue.4 , pp. 205-212
    • Ponisch, W.1    Mitrou, P.S.2    Merkle, K.3    Herold, M.4    Assmann, M.5    Wilhelm, G.6
  • 38
    • 52649177173 scopus 로고    scopus 로고
    • Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma [Electronic version]
    • September 15, 2008
    • Robinson, K.S., Williams, M.E., van der Jagt, R.H., Cohen, P., Herst, J.A., Tulpule, A., et al. (2008). Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma [Electronic version]. Journal of Clinical Oncology. Retrieved September 15, 2008, from http://jco.ascopubs.org/cgi/content/abstract/JCO.2008.17.0001v1
    • (2008) Journal of Clinical Oncology
    • Robinson, K.S.1    Williams, M.E.2    van der Jagt, R.H.3    Cohen, P.4    Herst, J.A.5    Tulpule, A.6
  • 39
    • 0036340530 scopus 로고    scopus 로고
    • In vitro studies with bendamustine: Enhanced activity in combination with rituximab
    • Rummel, M.J., Chow, K.U., Hoelzer, D., Mitrou, P.S., & Weidmann, E. (2002). In vitro studies with bendamustine: Enhanced activity in combination with rituximab. Seminars in Oncology, 29(4, Suppl. 13), 12-14.
    • (2002) Seminars In Oncology , vol.29 , Issue.4 SUPPL. 13 , pp. 12-14
    • Rummel, M.J.1    Chow, K.U.2    Hoelzer, D.3    Mitrou, P.S.4    Weidmann, E.5
  • 40
    • 41349109244 scopus 로고    scopus 로고
    • Bendamustine plus rituximab versus CHOP plus rituximab in the first-line treatment of patients with indolent and mantle cell lymphomas-First interim results of a randomized phase III study of the StiL (Study Group Indolent Lymphomas, Germany) [Abstract]
    • Rummel, M.J., von Grunhagen, U., Niederle, N., Rothmann, F., Ballo, H., Weidmann, E., et al. (2007). Bendamustine plus rituximab versus CHOP plus rituximab in the first-line treatment of patients with indolent and mantle cell lymphomas-First interim results of a randomized phase III study of the StiL (Study Group Indolent Lymphomas, Germany) [Abstract]. Blood, 110, 385.
    • (2007) Blood , vol.110 , pp. 385
    • Rummel, M.J.1    von Grunhagen, U.2    Niederle, N.3    Rothmann, F.4    Ballo, H.5    Weidmann, E.6
  • 42
    • 33845991547 scopus 로고    scopus 로고
    • Phase II trial of second-line bendamustine chemotherapy in relapsed small cell lung cancer patients
    • Schmittel, A., Knodler, M., Hortig, P., Schulze, K., Thiel, E., & Keilholz, U. (2007). Phase II trial of second-line bendamustine chemotherapy in relapsed small cell lung cancer patients. Lung Cancer, 55(1), 109-113.
    • (2007) Lung Cancer , vol.55 , Issue.1 , pp. 109-113
    • Schmittel, A.1    Knodler, M.2    Hortig, P.3    Schulze, K.4    Thiel, E.5    Keilholz, U.6
  • 43
    • 0036798734 scopus 로고    scopus 로고
    • In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia
    • Schwanen, C., Hecker, T., Hubinger, G., Wolfle, M., Rittgen, W., Bergmann, L., et al. (2002). In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia. Leukemia, 16(10), 2096-2105.
    • (2002) Leukemia , vol.16 , Issue.10 , pp. 2096-2105
    • Schwanen, C.1    Hecker, T.2    Hubinger, G.3    Wolfle, M.4    Rittgen, W.5    Bergmann, L.6
  • 44
    • 3442895330 scopus 로고    scopus 로고
    • In vitro modulation of Ara-CTP accumulation in fresh AML cells by bendamustine in comparison with fludarabine, 2CdA and gemcitabine
    • Staib, P., Schinkothe, T., & Dimski, T. (2007). In vitro modulation of Ara-CTP accumulation in fresh AML cells by bendamustine in comparison with fludarabine, 2CdA and gemcitabine. Blood, 94, 63a.
    • (2007) Blood , vol.94
    • Staib, P.1    Schinkothe, T.2    Dimski, T.3
  • 45
    • 0030005440 scopus 로고    scopus 로고
    • Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines
    • Strumberg, D., Harstrick, A., Doll, K., Hoffmann, B., & Seeber, S. (1996). Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines. Anti-Cancer Drugs, 7(4), 415-421.
    • (1996) Anti-Cancer Drugs , vol.7 , Issue.4 , pp. 415-421
    • Strumberg, D.1    Harstrick, A.2    Doll, K.3    Hoffmann, B.4    Seeber, S.5
  • 46
    • 33947305075 scopus 로고    scopus 로고
    • Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride
    • Teichert, J., Baumann, F., Chao, Q., Franklin, C., Bailey, B., Hennig, L., et al. (2007). Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride. Cancer Chemotherapy and Pharmacology, 59(6), 759-770.
    • (2007) Cancer Chemotherapy and Pharmacology , vol.59 , Issue.6 , pp. 759-770
    • Teichert, J.1    Baumann, F.2    Chao, Q.3    Franklin, C.4    Bailey, B.5    Hennig, L.6
  • 47
    • 24044442891 scopus 로고    scopus 로고
    • Bendamustine prolongs progression-free survival in metastatic breast cancer (MBC): A phase III prospective, randomized, multicenter trial of bendamustine hydrochloride, methotrexate and 5-fluorouracil (BMF) versus cyclophosphamide, methotrexate and 5-fluorouracil (CMF) as first-line treatment of MBC
    • von Minckwitz, G., Chernozemsky, I., Sirakova, L., Chilingirov, P., Souchon, R., Marschner, N., et al. (2005). Bendamustine prolongs progression-free survival in metastatic breast cancer (MBC): A phase III prospective, randomized, multicenter trial of bendamustine hydrochloride, methotrexate and 5-fluorouracil (BMF) versus cyclophosphamide, methotrexate and 5-fluorouracil (CMF) as first-line treatment of MBC. Anti-Cancer Drugs, 16(8), 871-877.
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.8 , pp. 871-877
    • von Minckwitz, G.1    Chernozemsky, I.2    Sirakova, L.3    Chilingirov, P.4    Souchon, R.5    Marschner, N.6
  • 48
    • 0036668672 scopus 로고    scopus 로고
    • Bendamustine is effective in relapsed or refractory aggressive non-Hodgkin's lymphoma
    • Weidmann, E., Kim, S.Z., Rost, A., Schuppert, H., Seipelt, G., Hoelzer, D., et al. (2002). Bendamustine is effective in relapsed or refractory aggressive non-Hodgkin's lymphoma. Annals of Oncology, 13(8), 1285-1289.
    • (2002) Annals of Oncology , vol.13 , Issue.8 , pp. 1285-1289
    • Weidmann, E.1    Kim, S.Z.2    Rost, A.3    Schuppert, H.4    Seipelt, G.5    Hoelzer, D.6


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