Experimental and kinetic studies of the Escherichia coli glucuronylsynthase: An engineered enzyme for the synthesis of glucuronide conjugates

Journal of Organic Chemistry

Volumn 76, Issue 7, 2011, Pages 1992-2000

  Wilkinson, Shane M ^a   Watson, Morgan A ^a   Willis, Anthony C ^a   McLeod, Malcolm D ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGRICULTURAL RESIDUE; AQUEOUS SOLUBILITY; COSOLVENTS; DEHYDROEPIANDROSTERONE; DONOR SUBSTRATES; DRUG TESTING; E. COLI; GLUCURONIDASE; GLUCURONIDES; GLYCOSYNTHASE; IMPROVED METHODS; KINETIC STUDY; OPTIMIZED CONDITIONS; POLAR SUBSTITUENTS; PRODUCT INHIBITION; SINGLE-STEP SYNTHESIS;

AGRICULTURAL WASTES; DRUG PRODUCTS; ENZYME KINETICS; ENZYMES; ESCHERICHIA COLI; KINETIC THEORY; METABOLISM; METABOLITES; SOAPS (DETERGENTS);

ENZYME INHIBITION;

DEHYDROEPIANDROSTERONE 3 BETA GLUCURONIDE; DETERGENT; ESCHERICHIA COLI BETA GLUCURONIDASE; ESCHERICHIA COLI GLUCURONYL SYNTHASE; ESCHERICHIA COLI PROTEIN; GLUCURONIDE; SOLVENT; STEROID; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); CONJUGATE; CONTROLLED STUDY; ENZYME ENGINEERING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HYDROPHOBICITY; METABOLITE; PH; TEMPERATURE;

ESCHERICHIA COLI; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; KINETICS; MOLECULAR STRUCTURE; PROTEIN ENGINEERING;

EID: 79953188703     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo101914s     Document Type: Article

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