The GAS41-PP2Cβ complex dephosphorylates p53 at serine 366 and regulates its stability

Journal of Biological Chemistry

Volumn 286, Issue 13, 2011, Pages 10911-10917

  Park, Jeong Hyeon ^a   Smith, Rebecca J ^a   Shieh, Sheau Yann ^b   Roeder, Robert G ^c  

^a MASSEY UNIVERSITY   (New Zealand)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURVIVAL; DEPHOSPHORYLATES; DEPHOSPHORYLATIONS; ECTOPIC EXPRESSIONS; GENOTOXIC; POST-TRANSLATIONAL MODIFICATIONS; PROTEASOMES; REGULATORY SUBUNITS; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSORS; UP-REGULATION; UV RADIATION;

AMINO ACIDS; ULTRAVIOLET RADIATION;

TUMORS;

NUCLEAR PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2; PHOSPHOPROTEIN PHOSPHATASE 2C BETA; PROTEIN GAS41; PROTEIN P53; SERINE; UNCLASSIFIED DRUG; MULTIPROTEIN COMPLEX; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; TP53 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; YEATS4 PROTEIN, HUMAN;

ARTICLE; CELL STRAIN; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME SPECIFICITY; ENZYME SUBUNIT; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; ULTRAVIOLET RADIATION; UPREGULATION; CELL LINE; GENETICS; GLIOMA; METABOLISM; PHOSPHORYLATION; RADIATION EXPOSURE;

CELL LINE; GLIOMA; HUMANS; MULTIPROTEIN COMPLEXES; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN STABILITY; SERINE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS; UP-REGULATION;

EID: 79953180952     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C110.210211     Document Type: Article

References (32)

1. Vousden, K. H., and Prives, C. (2009) Cell 137, 413-431
2. Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. (1993) Cell 75, 495-505
3. Poyurovsky, M. V., and Prives, C. (2006) Genes Dev. 20, 125-131
4. Bode, A. M., and Dong, Z. (2004) Nat. Rev. Cancer 4, 793-805
5. Olsson, A., Manzl, C., Strasser, A., and Villunger, A. (2007) Cell Death Differ. 14, 1561-1575
6. Toledo, F., and Wahl, G. M. (2006) Nat. Rev. Cancer 6, 909-923
7. Shieh, S. Y., Ikeda, M., Taya, Y., and Prives, C. (1997) Cell 91, 325-334
8. Chehab, N. H., Malikzay, A., Stavridi, E. S., and Halazonetis, T. D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 13777-13782
9. Bech-Otschir, D., Kraft, R., Huang, X., Henklein, P., Kapelari, B., Pollmann, C., and Dubiel, W. (2001) EMBO J. 20, 1630-1639
10. Katayama, H., Sasai, K., Kawai, H., Yuan, Z. M., Bondaruk, J., Suzuki, F., Fujii, S., Arlinghaus, R. B., Czerniak, B. A., and Sen, S. (2004) Nat. Genet. 36, 55-62
11. Li, H. H., Li, A. G., Sheppard, H. M., and Liu, X. (2004) Mol. Cell 13, 867-878
12. Xia, Y., Padre, R. C., De Mendoza, T. H., Bottero, V., Tergaonkar, V. B., and Verma, I. M. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 2629-2634
13. Moorhead, G. B., Trinkle-Mulcahy, L., and Ulke-Lemée, A. (2007) Nat. Rev. Mol. Cell Biol. 8, 234-244
14. Lammers, T., and Lavi, S. (2007) Crit. Rev. Biochem. Mol. Biol. 42, 437-461
15. Klumpp, S., Thissen, M. C., and Krieglstein, J. (2006) Biochem. Soc. Trans. 34, 1370-1375
16. Fischer, U., Heckel, D., Michel, A., Janka, M., Hulsebos, T., and Meese, E. (1997) Hum. Mol. Genet. 6, 1817-1822
17. Schulze, J. M., Wang, A. Y., and Kobor, M. S. (2009) Biochem. Cell Biol. 87, 65-75
18. Zeisig, D. T., Bittner, C. B., Zeisig, B. B., García- Cuéllar, M. P., Hess, J. L., and Slany, R. K. (2005) Oncogene 24, 5525-5532
19. Park, J. H., and Roeder, R. G. (2006) Mol. Cell. Biol. 26, 4006-4016
20. Park, J., Wood, M. A., and Cole, M. D. (2002) Mol. Cell. Biol. 22, 1307-1316
21. Doyon, Y., Selleck, W., Lane, W. S., Tan, S., and Côté, J. (2004) Mol. Cell. Biol. 24, 1884-1896
22. Jin, J., Cai, Y., Yao, T., Gottschalk, A. J., Florens, L., Swanson, S. K., Gutiérrez, J. L., Coleman, M. K., Workman, J. L., Mushegian, A., Washburn, M. P., Conaway, R. C., and Conaway, J. W. (2005) J. Biol. Chem. 280, 41207-41212
23. Tamura, S., Toriumi, S., Saito, J., Awano, K., Kudo, T. A., and Kobayashi, T. (2006) Cancer Sci. 97, 563-567
24. Le Guezennec, X., and Bulavin, D. V. (2010) Trends Biochem. Sci. 35, 109-114
25. Ou, Y. H., Chung, P. H., Sun, T. P., and Shieh, S. Y. (2005) Mol. Biol. Cell 16, 1684-1695
26. van Attikum, H., and Gasser, S. M. (2009) Trends Cell Biol. 19, 207-217
27. Llanos, S., Efeyan, A., Monsech, J., Dominguez, O., and Serrano, M. (2006) Cell Cycle 5, 1880-1885
28. Sun, W., Yu, Y., Dotti, G., Shen, T., Tan, X., Savoldo, B., Pass, A. K., Chu, M., Zhang, D., Lu, X., Fu, S., Lin, X., and Yang, J. (2009) Cell. Signal. 21, 95-102
29. Klumpp, S., Selke, D., and Krieglstein, J. (2003) Neurochem. Int. 42, 555-560
30. Hanada, M., Ninomiya-Tsuji, J., Komaki, K., Ohnishi, M., Katsura, K., Kanamaru, R., Matsumoto, K., and Tamura, S. (2001) J. Biol. Chem. 276, 5753-5759
31. Lotem, J., Benjamin, H., Netanely, D., Domany, E., and Sachs, L. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 16022-16027
32. Prajapati, S., Verma, U., Yamamoto, Y., Kwak, Y. T., and Gaynor, R. B. (2004) J. Biol. Chem. 279, 1739-1746