Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 7, 2011, Pages 2407-2417

  Jensen, Marie ^a   Schmidt, Steffen ^b   Fedosova, Natalya U ^a   Mollenhauer, Jan ^b   Jensen, Henrik H ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Anti proliferation; Digitoxin; Ethylene glycol; Na+, K+ ATPase

Indexed keywords

1,2 BIS(3 DIGITOXIGENIN)DISULFANE; 1,2 BIS(DIGITOXIGENIN 3 YLTHIO)ETHANE; 1,4 (1,4 DIMERCAPTO 1,4 DIDEOXYDIETHYLENE GLYCOL)BIS(DIGITOXIGENIN 3 YLSULFANE); 1,6 (1,6 DIMERCAPTO 1,6 DIDEOXYTRIETHYLENE GLYCOL)BIS(DIGITOXIGENIN 3 YLSULFANE); 2 (DIGITOXIGENIN 3 YLTHIO)ETHANOL; 3 DEOXY 3 MERCAPTOACETYLDIGITOXIGENIN; 3 EPI O 4 TOLUENESULFONYLDIGITOXIGENIN; 3 EPIDIGITOXIGENIN; 3 MERCAPTODIGITOXIGENIN; 4 (DIGITOXIGENIN 3 YLTHIO)DIETHYLENE GLYCOL; 6 (DIGITOXIGENIN 3 YLTHIO)TRIETHYLENE GLYCOL; 8 (DIGITOXIGENIN 3 YLTHIO)TETRAETHYLENE GLYCOL; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) INHIBITOR; ANTINEOPLASTIC AGENT; CARDIAC GLYCOSIDE; DIGITOXIGENIN; DIGITOXIGENONE; DIGITOXIN; ETHYLENE GLYCOL; MONOETHYLENE GLYCOL; STEROID; TERT BUTYLDIMEHYLSILYL 2 (DIGITOXIGENIN 3 YLTHIO)ETHANOL; TERT BUTYLDIMEHYLSILYL 4 (DIGITOXIGENIN 3 YLTHIO)DIETHYLENE GLYCOL; TERT BUTYLDIMEHYLSILYL 6 (DIGITOXIGENIN 3 YLTHIO)TRIETHYLENE GLYCOL; TERT BUTYLDIMEHYLSILYL 8 (DIGITOXIGENIN 3 YLTHIO)TETRAETHYLENE GLYCOL; TETRAETHYLENE GLYCOL; THIODIGITOXIGENIN; TRIETHYLENE GLYCOL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOMIMETIC MATERIALS; CARBOHYDRATE SEQUENCE; CELL LINE, TUMOR; DIGITOXIN; HUMANS; MOLECULAR SEQUENCE DATA; SODIUM-POTASSIUM-EXCHANGING ATPASE;

TETRA;

EID: 79953172855     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.02.016     Document Type: Article

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