The myosin light chain-IQGAP interaction: What is its function?

Cytoskeleton: Cell Movement, Cytokinesis and Organelles Organization

Volumn , Issue , 2010, Pages 139-147

  Timson, David J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79953172051     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (75)

1. Weissbach, L., Settleman, J., Kalady, M. F., Snijders, A. J., Murthy, A. E., Yan, Y. X. & Bernards, A. (1994). Identification of a human rasGAP-related protein containing calmodulin-binding motifs. J Biol Chem., 269, 20517-20521.
2. Hart, M. J., Callow, M. G., Souza, B. & Polakis, P. (1996). IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J., 15, 2997-3005.
3. McCallum, S. J., Wu, W. J. & Cerione, R. A. (1996). Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2. J Biol Chem., 271, 21732-21737.
4. Jeong, H. W., Li, Z., Brown, M. D. & Sacks, D. B. (2007). IQGAP1 binds Rap1 and modulates its activity. J Biol Chem., 282, 20752-20762.
5. Brill, S., Li, S., Lyman, C. W., Church, D. M., Wasmuth, J. J., Weissbach, L., Bernards, A. & Snijders, A. J. (1996). The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol Cell Biol., 16, 4869-4878.
6. Bernards, A. (2003). GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim Biophys Acta., 1603, 47-82.
7. Wang, S., Watanabe, T., Noritake, J., Fukata, M., Yoshimura, T., Itoh, N., Harada, T., Nakagawa, M., Matsuura, Y., Arimura, N. & Kaibuchi, K. (2007). IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J Cell Sci., 120, 567-577.
8. Osman, M. A. & Cerione, R. A. (1998). Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates cdc42p effects on the actin cytoskeleton. J Cell Biol., 142, 443-455.
9. Epp, J. A. & Chant, J. (1997). An IQGAP-related protein controls actin-ring formation and cytokinesis in yeast. Curr Biol., 7, 921-929.
10. Shannon, K. B. & Li, R. (1999). The multiple roles of Cyk1p in the assembly and function of the actomyosin ring in budding yeast. Mol Biol Cell., 10, 283-296.
11. Eng, K., Naqvi, N. I., Wong, K. C. & Balasubramanian, M. K. (1998). Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body. Curr Biol., 8, 611-621.
12. Li, C. R., Wang, Y. M. & Wang, Y. (2008). The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans. EMBO J., 27, 2998-3010.
13. Wendland, J. & Philippsen, P. (2002). An IQGAP-related protein, encoded by AgCYK1, is required for septation in the filamentous fungus Ashbya gossypii. Fungal Genet Biol., 37, 81-88.
14. Venturelli, C. R., Kuznetsov, S., Salgado, L. M. & Bosch, T. C. (2000). An IQGAP-related gene is activated during tentacle formation in the simple metazoan Hydra. Dev Genes Evol., 210, 458-463.
15. Nishimura, Y. & Mabuchi, I. (2003). An IQGAP-like protein is involved in actin assembly together with Cdc42 in the sea urchin egg. Cell Motil Cytoskeleton., 56, 207-218.
16. Faix, J., Clougherty, C., Konzok, A., Mintert, U., Murphy, J., Albrecht, R., Muhlbauer, B. & Kuhlmann, J. (1998). The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility. J Cell Sci., 111, 3059-3071.
17. Yamashiro, S., Noguchi, T. & Mabuchi, I. (2003). Localization of two IQGAPs in cultured cells and early embryos of Xenopus laevis. Cell Motil Cytoskeleton., 55, 36-50.
18. 2+, calmodulin, Cdc42 and the cytoskeleton. FEBS Lett., 542, 7-11.
19. Briggs, M. W. & Sacks, D. B. (2003). IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep., 4, 571-574.
20. Machesky, L. M. (1998). Cytokinesis: IQGAPs find a function. Curr Biol., 8, R202-5.
21. Mateer, S. C., Wang, N. & Bloom, G. S. (2003). IQGAPs: integrators of the cytoskeleton, cell adhesion machinery, and signaling networks. Cell Motil Cytoskeleton., 55, 147-155.
22. Mataraza, J. M., Briggs, M. W., Li, Z., Frank, R. & Sacks, D. B. (2003). Identification and characterization of the Cdc42-binding site of IQGAP1. Biochem Biophys Res Commun., 305, 315-321.
23. Owen, D., Campbell, L. J., Littlefield, K., Evetts, K. A., Li, Z., Sacks, D. B., Lowe, P. N. & Mott, H. R. (2008). The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. J Biol Chem., 283, 1692-1704.
24. Ren, J. G., Li, Z. & Sacks, D. B. (2007). IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci, U S A., 104, 10465-10469.
25. Roy, M., Li, Z. & Sacks, D. B. (2004). IQGAP1 binds ERK2 and modulates its activity. J Biol Chem.
26. Roy, M., Li, Z. & Sacks, D. B. (2005). IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol., 25, 7940-7952.
27. Nauert, J. B., Rigas, J. D. & Lester, L. B. (2003). Identification of an IQGAP1/AKAP79 complex in beta-cells. J Cell Biochem., 90, 97-108.
28. Yamaoka-Tojo, M., Ushio-Fukai, M., Hilenski, L., Dikalov, S. I., Chen, Y. E., Tojo, T., Fukai, T., Fujimoto, M., Patrushev, N. A., Wang, N., Kontos, C. D., Bloom, G. S. & Alexander, R. W. (2004). IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation. Circ Res., 95, 276-283.
29. 2+/calmodulin and Cdc42 signaling. J Biol Chem., 274, 464-470.
30. Joyal, J. L., Annan, R. S., Ho, Y. D., Huddleston, M. E., Carr, S. A., Hart, M. J. & Sacks, D. B. (1997). Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometry. J Biol Chem., 272, 15419-15425.
31. Li, Q. & Stuenkel, E. L. (2004). Calcium negatively modulates calmodulin interaction with IQGAP1. Biochem Biophys Res Commun., 317, 787-795.
32. Li, Z. & Sacks, D. B. (2003). Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem., 278, 4347-4352.
33. Mbele, G. O., Deloulme, J. C., Gentil, B. J., Delphin, C., Ferro, M., Garin, J., Takahashi, M. & Baudier, J. (2002). The zinc-and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes. J Biol Chem., 277, 49998-50007.
34. Bashour, A. M., Fullerton, A. T., Hart, M. J. & Bloom, G. S. (1997). IQGAP1, a Rac-and Cdc42-binding protein, directly binds and cross-links microfilaments. J Cell Biol., 137, 1555-1566.
35. Erickson, J. W., Cerione, R. A. & Hart, M. J. (1997). Identification of an actin cytoskeletal complex that includes IQGAP and the Cdc42 GTPase. J Biol Chem., 272, 24443-24447.
36. Mateer, S. C., McDaniel, A. E., Nicolas, V., Habermacher, G. M., Lin, M. J., Cromer, D. A., King, M. E. & Bloom, G. S. (2002). The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin. J Biol Chem., 277, 12324-12333.
37. Mateer, S. C., Morris, L. E., Cromer, D. A., Bensenor, L. B. & Bloom, G. S. (2004). Actin filament binding by a monomeric IQGAP1 fragment with a single calponin homology domain. Cell Motil Cytoskeleton., 58, 231-241.
38. Le Clainche, C., Schlaepfer, D., Ferrari, A., Klingauf, M., Grohmanova, K., Veligodskiy, A., Didry, D., Le, D., Egile, C., Carlier, M. F. & Kroschewski, R. (2007). IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway. J Biol Chem., 282, 426-435.
39. Watanabe, T., Wang, S., Noritake, J., Sato, K., Fukata, M., Takefuji, M., Nakagawa, M., Izumi, N., Akiyama, T. & Kaibuchi, K. (2004). Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell., 7, 871-883.
40. Fukata, M., Watanabe, T., Noritake, J., Nakagawa, M., Yamaga, M., Kuroda, S., Matsuura, Y., Iwamatsu, A., Perez, F. & Kaibuchi, K. (2002). Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell., 109, 873-885.
41. Kuroda, S., Fukata, M., Nakagawa, M., Fujii, K., Nakamura, T., Ookubo, T., Izawa, I., Nagase, T., Nomura, N., Tani, H., Shoji, I., Matsuura, Y., Yonehara, S. & Kaibuchi, K. (1998). Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science., 281, 832-835.
42. Kuroda, S., Fukata, M., Nakagawa, M. & Kaibuchi, K. (1999). Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion. Biochem Biophys Res Commun., 262, 1-6.
43. Li, Z., Kim, S. H., Higgins, J. M., Brenner, M. B. & Sacks, D. B. (1999). IQGAP1 and calmodulin modulate E-cadherin function. J Biol Chem., 274, 37885-37892.
44. Noritake, J., Watanabe, T., Sato, K., Wang, S. & Kaibuchi, K. (2005). IQGAP1: a key regulator of adhesion and migration. J Cell Sci., 118, 2085-2092.
45. Miyamoto, S., Baba, H., Kuroda, S., Kaibuchi, K., Fukuda, T., Maehara, Y. & Saito, T. (2000). Changes in E-cadherin associated with cytoplasmic molecules in well and poorly differentiated endometrial cancer. Br J Cancer., 83, 1168-1175.
46. Mataraza, J. M., Briggs, M. W., Li, Z., Entwistle, A., Ridley, A. J. & Sacks, D. B. (2003). IQGAP1 promotes cell motility and invasion. J Biol Chem.
47. Nabeshima, K., Shimao, Y., Inoue, T. & Koono, M. (2002). Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. Cancer Lett., 176, 101-109.
48. Nakamura, H., Fujita, K., Nakagawa, H., Kishi, F., Takeuchi, A., Aute, I. & Kato, H. (2005). Expression pattern of the scaffold protein IQGAP1 in lung cancer. Oncol Rep., 13, 427-431.
49. Morris, L. E., Bloom, G. S., Frierson, H. F., Jr & Powell, S. M. (2005). Nucleotide variants within the IQGAP1 gene in diffuse-type gastric cancers. Genes Chromosomes Cancer., 42, 280-286.
50. Mooseker, M. S. & Cheney, R. E. (1995). Unconventional myosins. Annu Rev Cell Dev Biol., 11, 633-675.
51. Rayment, I., Rypniewski, W. R., Schmidt-Base, K., Smith, R., Tomchick, D. R., Benning, M. M., Winkelmann, D. A., Wesenberg, G. & Holden, H. M. (1993). Three-dimensional structure of myosin subfragment-1: a molecular motor. Science., 261, 50-58.
52. Gulick, A. M. & Rayment, I. (1997). Structural studies on myosin II: communication between distant protein domains. Bioessays., 19, 561-569.
53. Timson, D. J. (2003). Fine tuning the myosin motor: the role of the essential light chain in striated muscle myosin. Biochimie., 85, 639-645.
54. Trybus, K. M. (1994). Role of myosin light chains. J Muscle Res Cell Motil., 15, 587-594.
55. Stepkowski, D. & Kakol, I. (1993). The significance of myosin light chains in mechanochemical coupling in skeletal muscle. Acta Biochim Pol., 40, 345-351.
56. Weissbach, L., Bernards, A. & Herion, D. W. (1998). Binding of myosin essential light chain to the cytoskeleton-associated protein IQGAP1. Biochem Biophys Res Commun., 251, 269-276.
57. Pathmanathan, S., Elliott, S. F., McSwiggen, S., Greer, B., Harriott, P., Irvine, G. B. & Timson, D. J. (2008). IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B. Mol Cell Biochem., 318, 43-51.
58. Pathmanathan, S., Barnard, E. & Timson, D. J. (2008). Interactions between the budding yeast IQGAP homologue Iqg1p and its targets revealed by a split-EGFP bimolecular fluorescence complementation assay. Cell Biol Int., 32, 1318-1322.
59. Lippincott, J. & Li, R. (1998). Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol., 140, 355-366.
60. Corbett, M., Xiong, Y., Boyne, J. R., Wright, D. J., Munro, E. & Price, C. (2006). IQGAP and mitotic exit network (MEN) proteins are required for cytokinesis and re-polarization of the actin cytoskeleton in the budding yeast, Saccharomyces cerevisiae. Eur J Cell Biol., 85, 1201-1215.
61. Boyne, J. R., Yosuf, H. M., Bieganowski, P., Brenner, C. & Price, C. (2000). Yeast myosin light chain, Mlc1p, interacts with both IQGAP and class II myosin to effect cytokinesis. J Cell Sci., 113 Pt 24, 4533-4543.
62. Osman, M. A., Konopka, J. B. & Cerione, R. A. (2002). Iqg1p links spatial and secretion landmarks to polarity and cytokinesis. J Cell Biol., 159, 601-611.
63. Korinek, W. S., Bi, E., Epp, J. A., Wang, L., Ho, J. & Chant, J. (2000). Cyk3, a novel SH3-domain protein, affects cytokinesis in yeast. Curr Biol., 10, 947-950.
64. Shannon, K. B. & Li, R. (2000). A myosin light chain mediates the localization of the budding yeast IQGAP-like protein during contractile ring formation. Curr Biol., 10, 727-730.
65. Luo, J., Vallen, E. A., Dravis, C., Tcheperegine, S. E., Drees, B. & Bi, E. (2004). Identification and functional analysis of the essential and regulatory light chains of the only type II myosin Myo1p in Saccharomyces cerevisiae. J Cell Biol., 165, 843-855.
66. Brown, S. S. (1997). Myosins in yeast. Curr Opin Cell Biol., 9, 44-48.
67. Ko, N., Nishihama, R., Tully, G. H., Ostapenko, D., Solomon, M. J., Morgan, D. O. & Pringle, J. R. (2007). Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell., 18, 5139-5153.
68. D'souza, V. M., Naqvi, N. I., Wang, H. & Balasubramanian, M. K. (2001). Interactions of Cdc4p, a myosin light chain, with IQ-domain containing proteins in Schizosaccharomyces pombe. Cell Struct Funct., 26, 555-565.
69. Wu, J. Q., Sirotkin, V., Kovar, D. R., Lord, M., Beltzner, C. C., Kuhn, J. R. & Pollard, T. D. (2006). Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast. J Cell Biol., 174, 391-402.
70. Wu, J. Q., Kuhn, J. R., Kovar, D. R. & Pollard, T. D. (2003). Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis. Dev Cell., 5, 723-734.
71. Kaufmann, A. & Philippsen, P. (2009). Of bars and rings: Hof1-dependent cytokinesis in multiseptated hyphae of Ashbya gossypii. Mol Cell Biol., 29, 771-783.
72. Bielak-Zmijewska, A., Kolano, A., Szczepanska, K., Maleszewski, M. & Borsuk, E. (2008). Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos. Dev Biol., 322, 21-32.
73. Just, I., Selzer, J., Wilm, M., von Eichel-Streiber, C., Mann, M. & Aktories, K. (1995). Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature, 375, 500-503.
74. Brandt, D. T., Marion, S., Griffiths, G., Watanabe, T., Kaibuchi, K. & Grosse, R. (2007). Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol., 178, 193-200.
75. Castrillon, D. H. & Wasserman, S. A. (1994). Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene. Development., 120, 3367-3377.