Iqg1p links spatial and secretion landmarks to polarity and cytokinesis

Journal of Cell Biology

Volumn 159, Issue 4, 2002, Pages 601-611

  Osman, Mahasin A ^a   Konopka, James B ^b   Cerione, Richard A ^a  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Bud4; Cytokinesis; Iqg1; Polarity; Sec3

Indexed keywords

BUD4 PROTEIN, S CEREVISIAE; CDC12 PROTEIN, S CEREVISIAE; CELL CYCLE PROTEIN; CYTOSKELETON PROTEIN; FUNGAL PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HYBRID PROTEIN; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; SACCHAROMYCES CEREVISIAE PROTEIN; SEC3 PROTEIN, S CEREVISIAE;

ARTICLE; BIOLOGICAL MODEL; CELL DIVISION; CELL POLARITY; GENETICS; MACROMOLECULE; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; TWO HYBRID SYSTEM; ULTRASTRUCTURE;

CELL CYCLE PROTEINS; CELL DIVISION; CELL POLARITY; CYTOSKELETAL PROTEINS; FUNGAL PROTEINS; GTP-BINDING PROTEINS; MACROMOLECULAR SUBSTANCES; MODELS, BIOLOGICAL; PROTEIN BINDING; RAS GTPASE-ACTIVATING PROTEINS; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0037175386     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.200205084     Document Type: Article

References (34)

1. Bashour, A.-M., A.T. Fullerton, M.J., Hart, and G.S. Bloom. 1997. IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross links microfilaments. J. Cell Biol. 137:1555-1566.
2. Bi, E., P. Maddox, D.J. Lew, E.D. Salmon, J.N. McMillan, E. Yeh, and J.R. Pringle. 1998. Involvement of an actomyosin ring in Saccharomyces cerevisiae. J. Cell Biol. 142:1301-1312.
3. Bowser, R., H. Muller, B. Govidan, and P. Novick. 1992. Sec8p and Sec15p are components of a plasma membrane-associated 19.5 S particle that may function downstream of Sec4p to control exocytosis. J. Cell Biol. 118:1041-1056.
4. Chant, J. 1996. Septin scaffolds and cleavage planes in Saccharomyces. Cell. 84:187-190.
5. Chant, J. 1999. Cell Polarity in yeast. Annu. Rev. Cell Dev. Biol. 15:365-391.
6. Chant, J., and I. Herskowitz. 1991. Genetic control of bud site selection in yeast by a set of gene products that comprise a morphogenetic pathway. Cell. 65:1203-1212.
7. Chant, J., and J.R. Pringle. 1995. Patterns of bud-site selection in the yeast Saccharomyces cerevisiae. J. Cell Biol. 129:751-765.
8. Cormack, B.P., G. Bertram, M. Egerton, N.A. Gow, S. Falkow, and A.J. Brown. 1997. Yeast-enhanced green fluorescent protein (yEGFP) a reporter of gene expression in Candida albicans. Microbiology. 143:303-311.
9. Epp, A.J., and J. Chant. 1997. An IQGAP-related protein controls actin-ring formation and cytokinesis in yeast. Curr. Biol. 7:921-929.
10. Erickson, J.W., R.A. Cerione, and M.J. Hart. 1997. Identification of an actin cytoskeleton complex that includes IQGAP and the Cdc42 GTPase. J. Biol. Chem. 272:24443-24447.
11. Finger, F., and P. Novick. 1997. Sec3 is involved in secretion and morphogenesis in. Saccharomyces cerevisiae. Mol. Biol. Cell. 8:647-662.
12. Finger, F., and P. Novick. 1998. Spatial regulation of exocyst: lessons from yeast. J. Cell Biol. 142:609-612.
13. Finger, F.P., T.E. Hughes, and P. Novick. 1998. Sec3p Is a spatial landmark for polarized secretion in budding yeast. Cell. 92:559-571.
14. Gietz, R.D., and A. Sugino. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene. 30:527-534.
15. Guo, W., F. Tamanoi, and P. Novick. 2001. Spatial regulation of the exocyst complex by Rho1 GTPase. Nat. Cell Biol. 3:353-360.
16. Haarer, B.K., A. Corbett, Y. Kweon, A.S. Petzold, P. Silver, and S.S. Brown. 1996. SEC3 Mutations are synthetically lethal with profilin mutations and cause defects in diploid-specific bud selection. Genetics. 144:495-510.
17. Hart, M.J., M.G. Callow, B. Souza, and P. Polakis. 1996. IQGAP1, a calmodulin-binding protein with a RasGAP-related domain, is a potential effector for Cdc42Hs. EMBO J. 15:2997-3005.
18. James, P., J. Halladay, and E.A. Craig. 1996. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics. 144:1425-1436.
19. Johnson, D.I., and J.R. Pringle. 1990. Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J. Cell Biol. 111:143-152.
20. Kuroda, S., M. Fukata, K. Kobayashi, M. Nakafuku, N. Nomura, A. Iwamatsu, and K. Kaibuchi. 1996. Identification of IQGAP as a putative target for the small GTPase, Cdc42 and Rac1. J. Biol. Chem. 271:23363-23367.
21. Lew, D.J., and S.I. Reed. 1995. Cell cycle control of morphogenesis in budding yeast. Curr. Opin. Genet. Dev. 5:17-23.
22. Lippincott, J., and R. Li. 1998. Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J. Cell Biol. 140:355-366.
23. Madden, K., and M. Snyder. 1998. Cell polarity and morphogenesis in budding yeast. Annu. Rev. Microbiol. 52:687-744.
24. McCallum, S.J., W.J. Wu, and R.A. Cerione. 1996. Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner IQGAP2. J. Biol. Chem. 271:21732-21737.
25. McCallum, S.J., J.W. Erickson, and RA. Cerione. 1998. Characterization of the Association of the actin-binding protein IQGAP, and activated Cdc42 with Golgi membrane. J. Biol. Chem. 273:22537-22544.
26. Nern, A., and RA. Arkowitz. 2000. G Proteins mediate changes in cell shape by stabilizing the axis of polarity. Mol. Cell. 5:853-864.
27. Osman, M., and R.A. Cerione. 1998. Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates Cdc42p effects on the actin cytoskeleton. J. Cell Biol. 142:443-455.
28. Pringle, J.R. 1991. Staining of bud scars and mother cell wall chitin with Calcofluor. Methods Enzymol. 194:732-735.
29. Sanders, S.L., and C. Fields. 1995. Bud-site selection is only skin deep. Curr. Biol. 5:1213-1215.
30. Sanders, S.L., and I. Herskowitz. 1996. The BUD4 protein of yeast, required for axial budding, is localized to the mother/BUD neck in a cell cycle-dependent manner. J. Cell Biol. 134:413-427.
31. Shannon, K.B., and R. Li. 1999. The multiple roles of Cyk1p in the assembly and function of the actomyosin ring in budding yeast. Mol. Biol. Cell. 10:283-296.
32. Shannon, K.B., and R.A. Li. 2000. Myosin light chain mediates the localization of the budding yeast IQGAP-like protein during contractile ring formation. Curr. Biol. 10:727-730.
33. TerBush, D.R., and P. Novick. 1995. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J. Cell Biol. 130:299-312.
34. Zhang, X., E. Bi, P. Novick, L. Du, K.G. Kozminski, J.H. Lipschutz, and W. Guo. 2001. Cdc42 interacts with the exocyst and regulates polarized secretion. J. Biol. Chem. 276:46745-46750.