The common modification in αA-crystallin in the lens, N101D, is associated with increased opacity in a mouse model

Journal of Biological Chemistry

Volumn 286, Issue 13, 2011, Pages 11579-11592

  Gupta, Ratna ^a   Asomugha, Chinwe O ^a   Srivastava, Om P ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORINS; BRIGHT-FIELD MICROSCOPY; CELLULAR CHANGES; CORTICAL REGIONS; CRYSTALLIN; DEAMIDATED; DEAMIDATION; DENUCLEATION; EXTRACELLULAR SPACE; FIBER CELLS; INSOLUBLE PROTEINS; LENS OPACITY; MEMBRANE PROTEINS; MOUSE MODELS; OPTICAL COHERENCE TOMOGRAPHY; PROTEIN AGGREGATION; SCANNING ELECTRON MICROSCOPIC; TRANSGENE; TRANSGENIC MICE; WILD TYPES;

BIOLOGICAL MEMBRANES; GENES; MICROSCOPIC EXAMINATION; OPACITY; OPTICAL INSTRUMENTS; PROTEINS; TOMOGRAPHY;

LENSES;

ALPHA CRYSTALLIN; AQUAPORIN; AQUAPORIN 0; ASPARAGINE; ASTATINE; UNCLASSIFIED DRUG; CRYAA PROTEIN, HUMAN; CRYSTALLIN; EYE PROTEIN;

ALPHA A CRYSTALLIN GENE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATARACT; CATARACTOGENESIS; CELL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEAMINATION; EXTRACELLULAR SPACE; GENE; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; IMAGE ANALYSIS; MOUSE; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN INTERACTION; PROTEIN MODIFICATION; TRANSGENE; WILD TYPE; ANIMAL; CELL MEMBRANE; DISEASE MODEL; GENETICS; HUMAN; LENS; METABOLISM; MISSENSE MUTATION; PATHOLOGY; TRANSGENIC MOUSE; ULTRASTRUCTURE;

MUS; MUS MUSCULUS;

AMINO ACID SUBSTITUTION; ANIMALS; AQUAPORINS; CATARACT; CELL MEMBRANE; CRYSTALLINS; DISEASE MODELS, ANIMAL; EYE PROTEINS; HUMANS; LENS, CRYSTALLINE; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE;

EID: 79953168449     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.148627     Document Type: Article

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