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8
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69949108747
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Semicarbazones and their thio derivatives are often found in biologically relevant molecules. See
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Semicarbazones and their thio derivatives are often found in biologically relevant molecules. See: Yu, Y.; Kalinowski, D. S.; Kovacevic, Z.; Siafakas, A. R.; Jansson, P. J.; Stefani, C.; Lovejoy, D. B.; Sharpe, P. C.; Bernhardt, P. V.; Richardson, D. R. J. Med. Chem. 2009, 52, 5271
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Yu, Y.1
Kalinowski, D.S.2
Kovacevic, Z.3
Siafakas, A.R.4
Jansson, P.J.5
Stefani, C.6
Lovejoy, D.B.7
Sharpe, P.C.8
Bernhardt, P.V.9
Richardson, D.R.10
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Lobana, T.S.1
Sharma, R.2
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Klayman, D. L.; Bartosevich, J. F.; Griffin, T. S.; Mason, C. J.; Scovill, J. P. J. Med. Chem. 1979, 22, 855
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Bartosevich, J.F.2
Griffin, T.S.3
Mason, C.J.4
Scovill, J.P.5
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12
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50949099971
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Semicarbazones are commonly synthesized by condensation of carbonyl compounds with the corresponding semicarbazide. See
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Semicarbazones are commonly synthesized by condensation of carbonyl compounds with the corresponding semicarbazide. See: de Oliveira, R. B.; de Souza-Fagundes, E. M.; Soares, R. P. P.; Andrade, A. A.; Krettli, A. U.; Zani, C. L. Eur. J. Med. Chem. 2008, 43, 1983
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De Oliveira, R.B.1
De Souza-Fagundes, E.M.2
Soares, R.P.P.3
Andrade, A.A.4
Krettli, A.U.5
Zani, C.L.6
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13
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79953229457
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Unpublished results.
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Unpublished results.
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14
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84961971284
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For preparation of N -hydroxyureas see
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For preparation of N -hydroxyureas see: Paz, J.; Pérez-Balado, C.; Iglesias, B.; Muñoz, L. J. Org. Chem. 2010, 75, 8039
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Paz, J.1
Pérez-Balado, C.2
Iglesias, B.3
Muñoz, L.4
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15
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79953178128
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The oxidation of N -hydroxyureas in the absence of amine afforded a 1:1 mixture of the corresponding symmetrical urea and N -carbamoyloxyurea (80% yield). See Supporting Information for details (compounds 38 and 39).
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The oxidation of N -hydroxyureas in the absence of amine afforded a 1:1 mixture of the corresponding symmetrical urea and N -carbamoyloxyurea (80% yield). See Supporting Information for details (compounds 38 and 39).
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16
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79953231927
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Various hindered amines give rise to the urea as the only product under the same reaction conditions. See Supporting Information for details (compounds 18 and 19).
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Various hindered amines give rise to the urea as the only product under the same reaction conditions. See Supporting Information for details (compounds 18 and 19).
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17
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0343341825
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Part 1;, Ed.; Interscience: New York,; pp .
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Boyer, J. H. In The Chemistry of the Nitro and Nitroso Groups, Part 1; Feuer, H., Ed.; Interscience: New York, 1969; pp 278 - 283.
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The Chemistry of the Nitro and Nitroso Groups
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Boyer, J.H.1
Feuer, H.2
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0033603371
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Davey, M. H.; Lee, V. Y.; Miller, R. D.; Marks, T. J. J. Org. Chem. 1999, 64, 4976
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Abe, T.; Joo, Y.-H.; Tao, G.-H.; Teamley, B.; Shreeve, J. M. Chem.-Eur. J. 2009, 15, 4102
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Tao, G.-H.3
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Shreeve, J.M.5
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22
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84956130826
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For a precedent on the isomerization of a carbamoyl azo compound to the corresponding semicarbazone see
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For a precedent on the isomerization of a carbamoyl azo compound to the corresponding semicarbazone see: Horner, L.; Fernekess, H. Chem. Ber. 1961, 94, 712
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(1961)
Chem. Ber.
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Horner, L.1
Fernekess, H.2
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23
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79953193317
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See also ref 12 for the isomerization of trifluoromethylazoalkanes to hydrazones.
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See also ref 12 for the isomerization of trifluoromethylazoalkanes to hydrazones.
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24
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79953197447
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See Supporting Information for a detailed discussion of the calculation results.
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See Supporting Information for a detailed discussion of the calculation results.
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26
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33748055108
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González Moa, M. J.; Mandado, M.; Mosquera, R. A. Chem. Phys. Lett. 2006, 428, 255
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González Moa, M.J.1
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Mosquera, R.A.3
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