Synthesis and antimalarial activity of semicarbazone and thiosemicarbazone derivatives

European Journal of Medicinal Chemistry

Volumn 43, Issue 9, 2008, Pages 1983-1988

  de Oliveira, Renata B ^a   de Souza Fagundes, Elaine M ^a   Soares, Rodrigo P P ^a   Andrade, Anderson A ^a   Krettli, Antoniana U ^a   Zani, Carlos L ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Antiplasmodial; PBMC; Semicarbazone; Thiosemicarbazone

Indexed keywords

6,6 DIMETHYLNORPIN 2 ENE 2 CARBOXYALDEHYDE THIOSEMICARBAZONE; CHLOROQUINE; SEMICARBAZONE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MALARIA; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; REACTION ANALYSIS;

ANIMALS; CELL PROLIFERATION; HUMANS; LYMPHOCYTES; MALARIA; MICE; PLASMODIUM FALCIPARUM; SEMICARBAZONES; THIOSEMICARBAZONES;

EID: 50949099971     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.11.012     Document Type: Article

References (24)

1. World Health Organization, Geneva, 2006 .
2. Beraldo H. Quim. Nova 27 (2004) 461-471
3. Klayman D.L., Bartosevich J.F., Griffin T.S., Mason C.J., and Scovill J.P. J. Med. Chem. 22 (1979) 855-862
4. Du X., Guo C., Hansell E., Doyle P.S., Caffrey C.R., Holler T.P., McKerrow J.H., and Cohen F.E. J. Med. Chem. 45 (2002) 2695-2707
5. Chiyanzu I., Hansell E., Gut J., Rosenthal P.J., McKerrow J.H., and Chibale K. Bioorg. Med. Chem. Lett. 13 (2003) 3527-3530
6. Greenbaum D.C., Mackey Z., Hansell E., Doyle P., Gut J., Caffrey C.R., Lehrman J., Rosenthal P.J., McKerrow J.H., and Chibale K. J. Med. Chem. 47 (2004) 3212-3219
7. Fujii N., Mallari J.P., Hansell E.J., Mackey Z., Doyle P., Zhou Y.M., Gut J., Rosenthal P.J., McKerrow J.H., and Guy R.K. Bioorg. Med. Chem. Lett. 15 (2005) 121-123
8. Pandeya S.N., Mishra V., Singh P.N., and Rupainwar D.C. Pharmacol. Res. 37 (1998) 17-22
9. Trager W., and Jensen J.B. Science 193 (1976) 673-675
10. Desjardins R.E., Canfield C.J., Haynes J.D., and Chulay J.D. Antimicrob. Agents Chemother 16 (1979) 710-718
11. Souza-Fagundes E.M., Gazzinelli G., Parreira G.G., Martins-Filho O.A., Amarante-Mendes G.P., Corrêa-Oliveira R., and Zani C.L. Int. Immunopharmacol. 3 (2003) 383-392
12. Pritzkow W., and Muller K.A. Chem. Ber. 89 (1956) 2321-2328
13. Miropol'skaya M.A., Mel'nik S.Y., Fradkina T.S., Samokhvalov G.I., and Petrov A.D. Dokl. Akad. Nauk SSSR. 144 (1962) 1312-1313
14. W.C. Meuly, P. Gradeff, FR 1384137, 1965.
15. Retamar J.B. Bull. Soc. Chim. Fr. 4 (1966) 1227-1231
16. Wilson H.R., Revankar G.R., and Tolman R.L. J. Med. Chem. 17 (1974) 760-761
17. Kolb V.M., Stupar J.W., Janota T.E., and Duax W.L. J. Org. Chem. 54 (1989) 2341-2346
18. Steinbach M.M., and Baker H. Proc. Soc. Exp. Biol. Med. 74 (1950) 595-596
19. Bernstein J., Yale H.L., Losee K., Holsing M., Martins J., and Lott W.A. J. Am. Chem. Soc. 73 (1951) 906-912
20. W. Pei, L. Sun, M. Sun, CN1762989, 2006.
21. Y. Wang, S.X. Cai, N.C. Lan, J.F.W. Kcana, V.I. Ilyin, E. Weber, WO9847869,1998.
22. Somogyi L. Heterocycles 63 (2004) 2243-2267
23. Peters W. Parasitology 90 (1985) 705-715
24. Carvalho L.H., Brandão M.G.L., Santos-Filho D., Lopes J.L.C., and Krettli A.U. Braz. J. Biol. Med. Res. 24 (1991) 1113-1123