Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP

Biochemical and Biophysical Research Communications

Volumn 407, Issue 1, 2011, Pages 158-162

  Karimpour, Sarvenaz ^a   Davoodi, Jamshid ^b   Ghahremani, Mohammad Hossein ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TEHRAN   (Iran)

Author keywords

APAF1; Intrinsic apoptosis pathway; NAIP; Nucleotide Binding Oligomerization Domain

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CYTOCHROME C; LYSINE; NEURONAL APOPTOSIS INHIBITORY PROTEIN; PROCASPASE 3; PROCASPASE 9; THREONINE;

APOPTOSIS; ARTICLE; AUTOPROTEOLYSIS; BINDING SITE; CIRCULAR DICHROISM; ENZYME INHIBITION; FEMALE; GENETIC TRANSFECTION; GENETIC VARIABILITY; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; APOPTOSOMES; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BINDING SITES; CASPASE 3; CASPASE 9; HUMANS; LYSINE; MUTATION; NEURONAL APOPTOSIS-INHIBITORY PROTEIN;

EID: 79953161325     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.02.130     Document Type: Article

References (24)

1. Roy N., Mahadevan M.S., McLean M., Shutler G., Yaraghi Z., Farahani R., Baird S., Besner-Johnston A., Lefebvre C., Kang X., et al. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 1995, 80:167-178.
2. Watihayati M.S., Fatemeh H., Marini M., Atif A.B., Zahiruddin W.M., Sasongko T.H., Tang T.H., Zabidi-Hussin Z.A., Nishio H., Zilfalil B.A. Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy. Brain Dev. 2009, 31:42-45.
3. Ingram-Crooks J., Holcik M., Drmanic S., MacKenzie A.E. Distinct expression of neuronal apoptosis inhibitory protein (NAIP) during murine development. NeuroReport 2002, 13:397-402.
4. Hutchison J.S., Derrane R.E., Johnston D.L., Gendron N., Barnes D., Fliss H., King W.J., Rasquinha I., MacManus J., Robertson G.S., MacKenzie A.E. Neuronal apoptosis inhibitory protein expression after traumatic brain injury in the mouse. J. Neurotrauma 2001, 18:1333-1347.
5. Crocker S.J., Wigle N., Liston P., Thompson C.S., Lee C.J., Xu D., Roy S., Nicholson D.W., Park D.S., MacKenzie A., Korneluk R.G., Robertson G.S. NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease. Eur. J. NeuroSci. 2001, 14:391-400.
6. Mikrogianakis A., Shaye R.E., Griffin P., Kawesa S., Lockwood J., Gendron N.H., Gaboury I., Merali Z., Mackenzie A.E., Hutchison J.S. Hypoxia alters the expression of inhibitor of apoptosis proteins after brain trauma in the mouse. J. Neurotrauma 2007, 24:338-353.
7. Christie L.A., Su J.H., Tu C.H., Dick M.C. Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains. Neurobiol. Dis. 2007, 26:165-173.
8. Maier J.K., Lahoua Z., Gendron N.H., Fetni R., Johnston A., Davoodi J., Rasper D., Roy S., Slack R.S., Nicholson D.W., MacKenzie A.E. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. J. Neurosci. 2002, 22:2035-2043.
9. Davoodi J., Lin L., Kelly J., Liston P., MacKenzie A.E. Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. J. Biol. Chem. 2004, 279:40622-40628.
10. Davoodi J., Ghahremani M.H., Es-Haghi A., Mohammad-Gholi A. A Mackenzie, neuronal apoptosis inhibitory protein NAIP is an inhibitor of procaspase-9. Int. J. Biochem. Cell Biol. 2010, 42:958-964.
11. Eckelman B.P., Salvesen G.S. The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J. Biol. Chem. 2006, 281:3254-3260.
12. Yang Y., Yu X. Regulation of apoptosis: the ubiquitous way. FASEB J. 2003, 17:790-799.
13. Samuel T., Welsh K., Lober T., Togo S.H., Zapata J.M., Reed J.C. Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. J. Biol. Chem. 2006, 281:1080-1090.
14. Bertrand M.J., Milutinovic S., Dickson K.M., Ho W.C., Boudreault A., Durkin J., Gillard J.W., Jaquith J.B., Morris S.J., Barker P.A. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 2008, 30:689-700.
15. Ma L., Huang Y., Song Z., Feng S., Tian X., Du W., Qiu X., Heese K., Wu M. Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. Cell Death Differ. 2006, 13:2079-2088.
16. Damiano J.S., Oliveira V., Welsh K., Reed J.C. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem. J. 2004, 381:213-219.
17. Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., Akey C.W. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol. Cell 2002, 9:423-432.
18. Cain K., Bratton S.B., Langlais C., Walker G., Brown D.G., Sun X.M., Cohen G.M. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. J. Biol. Chem. 2000, 275:6067-6070.
19. Chang D.W., Ditsworth D., Liu H., Srinivasula S.M., Alnemri E.S., Yang X. Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases. J. Biol. Chem. 2003, 278:16466-16469.
20. Shi Y. Caspase activation: revisiting the induced proximity model. Cell 2004, 117:855-858.
21. Davoodi J., Drown P.M., Bledsoe R.K., Wallin R., Reinhart G.D., Hutson S.M. Overexpression and characterization of the human mitochondrial and cytosolic branched-chain aminotransferases. J. Biol. Chem. 1998, 273:4982-4989.
22. Riedl S.J., Li W., Chao Y., Schwarzenbacher R., Shi Y. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature 2005, 434:926-933.
23. Davoodi J., Mohammad-Gholi A., Es-Haghi A., MacKenzie A. W323S variant of Xiap-BIR3 binds to SMAC but not caspase-9. J. Biochem. 2007, 141:293-299.
24. Fuentes-Prior P., Salvesen G.S. The protein structures that shape caspase activity, Specificity, activation and inhibition. Biochem. J. 2004, 384:201-232.