메뉴 건너뛰기




Volumn 7, Issue 3, 2011, Pages 355-364

Eribulin mesylate: A promising new antineoplastic agent for locally advanced or metastatic breast cancer

Author keywords

chemotherapy; efficacy; eribulin mesylate; metastatic breast cancer; nontaxane microtubule dynamics inhibitor; tolerability; tubulin targeted agents

Indexed keywords

ANTHRACYCLINE; CAPECITABINE; ERIBULIN; KETOCONAZOLE; PACLITAXEL; TAXANE DERIVATIVE; VINBLASTINE;

EID: 79953152351     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.10.186     Document Type: Article
Times cited : (6)

References (54)
  • 2
    • 38349038425 scopus 로고    scopus 로고
    • Westernising? Women's risks? Breast cancer in lower-income countries
    • Porter P: Westernising women's risks? Breast cancer in lower-income countries. N. Engl. J. Med. 358, 213-216 (2008).
    • (2008) N. Engl. J. Med , vol.358 , pp. 213-216
    • Porter, P.1
  • 4
    • 34147167656 scopus 로고    scopus 로고
    • Achievements in systemic therapies in the pregenomic era in metastatic breast cancer
    • DOI 10.1634/theoncologist.12-3-253
    • Colozza M, de Azambuja E, Personeni N, Lebrun F, Piccart MJ, Cardoso F: Achievements in systemic therapies in the pregenomic era in metastatic breast cancer. Oncologist 12, 253-270 (2007). (Pubitemid 46556792)
    • (2007) Oncologist , vol.12 , Issue.3 , pp. 253-270
    • Colozza, M.1    De Azambuja, E.2    Personeni, N.3    Lebrun, F.4    Piccart, M.J.5    Cardoso, F.6
  • 5
    • 44049097644 scopus 로고    scopus 로고
    • Microtubules: A dynamic target in cancer therapy
    • Pasquier E, Kavallaris M: Microtubules: a dynamic target in cancer therapy. IUBMB Life 60, 165-170 (2008).
    • (2008) IUBMB Life , vol.60 , pp. 165-170
    • Pasquier, E.1    Kavallaris, M.2
  • 6
    • 38449097524 scopus 로고    scopus 로고
    • Mechanisms of multidrug resistance: The potential role of microtubule-stabilizing agents
    • Fojo T, Menefee M: Mechanisms of multidrug resistance: the potential role of microtubule-stabilizing agents. Ann. Oncol. 18(Suppl. 5), V3-V8 (2007).
    • (2007) Ann. Oncol , vol.18 , Issue.SUPPL. 5
    • Fojo, T.1    Menefee, M.2
  • 7
    • 44449148739 scopus 로고    scopus 로고
    • Potential mechanisms of resistance to microtubule inhibitors
    • DOI 10.1053/j.seminoncol.2008.02.003, PII S0093775408000195
    • Kavallaris M, Annereau JP, Barret JM: Potential mechanisms of resistance to microtubule inhibitors. Semin. Oncol. 35, S22-S27 (2008). (Pubitemid 351758950)
    • (2008) Seminars in Oncology , vol.35 , Issue.SUPPL. 3
    • Kavallaris, M.1    Annereau, J.-P.2    Barret, J.-M.3
  • 8
    • 67049133438 scopus 로고    scopus 로고
    • Treatment options for breast cancer resistant to anthracycline and taxane
    • Moreno-Aspitia A, Perez EA: Treatment options for breast cancer resistant to anthracycline and taxane. Mayo Clin. Proc. 84, 533-545 (2009).
    • (2009) Mayo Clin. Proc , vol.84 , pp. 533-545
    • Moreno-Aspitia, A.1    Perez, E.A.2
  • 12
    • 33645798077 scopus 로고    scopus 로고
    • Capecitabine monotherapy: Safe and effective treatment for metastatic breast cancer
    • Ershler WB: Capecitabine monotherapy: safe and effective treatment for metastatic breast cancer. Oncologist 11, 325-335 (2006).
    • (2006) Oncologist , vol.11 , pp. 325-335
    • Ershler, W.B.1
  • 15
    • 37449001322 scopus 로고    scopus 로고
    • How do microtubule-targeted drugs work? An overview
    • Jordan MA, Kamath K: How do microtubule-targeted drugs work? An overview. Curr. Cancer Drug Targets 7, 730-742 (2007).
    • (2007) Curr. Cancer Drug Targets , vol.7 , pp. 730-742
    • Jordan, M.A.1    Kamath, K.2
  • 16
    • 52949122818 scopus 로고    scopus 로고
    • Neuropathy associated with microtubule inhibitors: Diagnosis, incidence, and management
    • Swain SM, Arezzo JC: Neuropathy associated with microtubule inhibitors: diagnosis, incidence, and management. Clin. Adv. Hematol. Oncol. 6, 455-467 (2008).
    • (2008) Clin. Adv. Hematol. Oncol , vol.6 , pp. 455-467
    • Swain, S.M.1    Arezzo, J.C.2
  • 17
    • 68349109083 scopus 로고    scopus 로고
    • Taxol (paclitaxel), package insert. Bristol- Myers Squibb Company Baxter Oncology GmbH, Halle/Westfalen, Germany
    • Taxol (paclitaxel), package insert. Bristol- Myers Squibb Company. Ixampra Kit (ixabepilone), prescribing information. Baxter Oncology GmbH, Halle/Westfalen, Germany (2007).
    • (2007) Ixampra Kit (Ixabepilone), Prescribing Information
  • 18
    • 33646172454 scopus 로고    scopus 로고
    • Novel formulations of taxanes: A review. Old wine in a new bottle?
    • Hennenfent KL, Govindan R: Novel formulations of taxanes: a review. Old wine in a new bottle? Ann. Oncol. 17, 735-749 (2006).
    • (2006) Ann. Oncol , vol.17 , pp. 735-749
    • Hennenfent, K.L.1    Govindan, R.2
  • 19
    • 0027080065 scopus 로고
    • Preclinical and clinical pharmacology of vinca alkaloids
    • Zhou XJ, Rahmani R: Preclinical and clinical pharmacology of vinca alkaloids. Drugs 44(Suppl. 4), 1-16 (1992). (Pubitemid 23025990)
    • (1992) Drugs , vol.44 , Issue.SUPPL. 4 , pp. 1-16
    • Zhou, X.1    Rahmani, R.2
  • 20
    • 79953129798 scopus 로고    scopus 로고
    • ABRAXANE®, prescribing information. Abraxis Bioscience Inc.
    • ABRAXANE®, prescribing information. Abraxis Bioscience Inc. (2007).
    • (2007)
  • 22
    • 0022709534 scopus 로고
    • Halichondrins: Antitumor polyether macrolides from a marine sponge
    • Hirata Y, Uemura D: Halichondrins: antitumor polyether macrolides from a marine sponge. Pure Appl. Chem. 58, 701-710 (1986). (Pubitemid 16557441)
    • (1986) Pure and Applied Chemistry , vol.58 , Issue.5 , pp. 701-710
    • Hirata Yoshimasa1    Uemura Daisuke2
  • 23
    • 0026069885 scopus 로고
    • Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin: Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data
    • Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E: Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J. Biol. Chem. 266, 15882-15889 (1991). (Pubitemid 21907740)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.24 , pp. 15882-15889
    • Bai, R.1    Paull, K.D.2    Herald, C.L.3    Malspeis, L.4    Pettit, G.R.5    Hamel, E.6
  • 24
    • 0026774529 scopus 로고
    • Total synthesis of halichondrin B and norhalichondrin B
    • Aicher TD, Buszek KR, Fang FG, et al. Total synthesis of halichondrin B and norhalichondrin B. J. Am. Chem. Soc. 114, 3162-3164 (1992).
    • (1992) J. Am. Chem. Soc , vol.114 , pp. 3162-3164
    • Aicher, T.D.1    Buszek, K.R.2    Fang, F.G.3
  • 26
    • 67449117538 scopus 로고    scopus 로고
    • Antiproliferative effects of halichondrin B analog eribulin mesylate (E7389) against paclitaxel-resistant human cancer cells in vitro
    • Kuznetsov G, TenDyke K, Yu MJ, Littlefield BA: Antiproliferative effects of halichondrin B analog eribulin mesylate (E7389) against paclitaxel-resistant human cancer cells in vitro. Proc. Am. Assoc. Cancer Res. 48, 275 (2007).
    • (2007) Proc. Am. Assoc. Cancer Res. , vol.48 , pp. 275
    • Kuznetsov, G.1    Tendyke, K.2    Yu, M.J.3    Littlefield, B.A.4
  • 27
    • 84975897156 scopus 로고    scopus 로고
    • Discovery of E7389, a fully synthetic macrocyclic ketone analog of halichondrin B
    • Cragg GM, Kingston DGI, Newman DJ (Eds). Taylor & Francis Group (CRC Press), FL, USA
    • Yu MJ, Kishi Y, Littlefield BA: Discovery of E7389, a fully synthetic macrocyclic ketone analog of halichondrin B. In: Anticancer Agents from Natural Products. Cragg GM, Kingston DGI, Newman DJ (Eds). Taylor & Francis Group (CRC Press), FL, USA, 241-265 (2005).
    • (2005) Anticancer Agents from Natural Products , pp. 241-265
    • Yu, M.J.1    Kishi, Y.2    Littlefield, B.A.3
  • 30
    • 4143052665 scopus 로고    scopus 로고
    • Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389
    • DOI 10.1158/0008-5472.CAN-04-1169
    • Kuznetsov G, Towle MJ, Cheng H, et al. Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389. Cancer Res. 64, 5760-5766 (2004). (Pubitemid 39095575)
    • (2004) Cancer Research , vol.64 , Issue.16 , pp. 5760-5766
    • Kuznetsov, G.1    Towle, M.J.2    Cheng, H.3    Kawamura, T.4    TenDyke, K.5    Liu, D.6    Kishi, Y.7    Yu, M.J.8    Littlefield, B.A.9
  • 31
    • 51049119664 scopus 로고    scopus 로고
    • Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase
    • Okouneva T, Azarenko O, Wilson L, Littlefield BA, Jordan MA: Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol. Cancer Ther. 7, 2003-2011 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2003-2011
    • Okouneva, T.1    Azarenko, O.2    Wilson, L.3    Littlefield, B.A.4    Ma, J.5
  • 32
    • 76749127634 scopus 로고    scopus 로고
    • Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability
    • Smith JA, Wilson L, Azarenko O, et al. Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry 49, 1331-1337 (2010).
    • (2010) Biochemistry , vol.49 , pp. 1331-1337
    • Smith, J.A.1    Wilson, L.2    Azarenko, O.3
  • 33
    • 69049106647 scopus 로고    scopus 로고
    • Macromolecular interaction of halichondrin B analogs eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation
    • Alday PH, Correia JJ: Macromolecular interaction of halichondrin B analogs eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation. Biochemistry 48, 7927-7938 (2009).
    • (2009) Biochemistry , vol.48 , pp. 7927-7938
    • Alday, P.H.1    Correia, J.J.2
  • 34
    • 33745000162 scopus 로고    scopus 로고
    • A Phase i pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: A California Cancer Consortium trial
    • Abstract 3036
    • Synold TW, Morgan RJ, Newman EM, et al. A Phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: a California Cancer Consortium trial. J. Clin. Oncol. 23, Abstract 3036 (2005).
    • (2005) J. Clin. Oncol , vol.23
    • Synold, T.W.1    Morgan, R.J.2    Newman, E.M.3
  • 35
    • 36849083035 scopus 로고    scopus 로고
    • Eribulin, a simplified ketone analog of the tubulin inhibitor halichondrin B, for the potential treatment of cancer
    • Newman S: Eribulin, a simplified ketone analog of the tubulin inhibitor halichondrin B, for the potential treatment of cancer. Curr. Opin. Investig. Drugs 8, 1057-1066 (2007). (Pubitemid 350224331)
    • (2007) Current Opinion in Investigational Drugs , vol.8 , Issue.12 , pp. 1057-1066
    • Newman, S.1
  • 36
    • 67449123315 scopus 로고    scopus 로고
    • Phase i study of eribulin mesylate (E7389) administered once every 21 days in patients with advanced solid tumors
    • Tan AR, Rubin EH, Walton DC, et al. Phase I study of eribulin mesylate (E7389) administered once every 21 days in patients with advanced solid tumors. Clin. Cancer Res. 15, 4213-4218 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4213-4218
    • Tan, A.R.1    Rubin, E.H.2    Walton, D.C.3
  • 37
    • 67449147109 scopus 로고    scopus 로고
    • A Phase i study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid tumors
    • Goel S, Mita AC, Mita M, et al. A Phase I study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid tumors. Clin. Cancer Res. 15, 4207-4212 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4207-4212
    • Goel, S.1    Mita, A.C.2    Mita, M.3
  • 38
    • 47549107022 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of E7389, a Halichodrin B analog with novel anti-tubulin activity: Results of two Phase i studies with different schedules of administration
    • Abstract 2013
    • Wong N, Desjardins C, Silberman S, Lewis M: Pharmacokinetics (PK) of E7389, a Halichodrin B analog with novel anti-tubulin activity: results of two Phase I studies with different schedules of administration. J. Clin. Oncol. 23, Abstract 2013 (2005).
    • (2005) J. Clin. Oncol , vol.23
    • Wong, N.1    Desjardins, C.2    Silberman, S.3    Lewis, M.4
  • 39
    • 67449159949 scopus 로고    scopus 로고
    • A Phase i study of eribulin mesylate (E7389) in patients with refractory cancers
    • Abstract 446
    • Minami H, Mukohara T, Nagai S, Mukai H, Namiki M: A Phase I study of eribulin mesylate (E7389) in patients with refractory cancers. Eur. J. Cancer Suppl. 6, Abstract 446 (2008).
    • (2008) Eur. J. Cancer , Issue.SUPPL. 6
    • Minami, H.1    Mukohara, T.2    Nagai, S.3    Mukai, H.4    Namiki, M.5
  • 40
    • 47549112107 scopus 로고    scopus 로고
    • Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4
    • Zhang ZY, King BM, Pelletier RD, Wong YN: Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4. Cancer Chemother. Pharmacol. 62, 707-716 (2008).
    • (2008) Cancer Chemother. Pharmacol , vol.62 , pp. 707-716
    • Zhang, Z.Y.1    King, B.M.2    Pelletier, R.D.3    Wong, Y.N.4
  • 41
    • 79551559614 scopus 로고    scopus 로고
    • Eribulin mesylate phamacokinetics in patients with solid tumors receiving repeated oral ketoconazole (KET)
    • Berlin Germany 16-19 November
    • Devriese LA, Wanders J, Jenner A, et al. Eribulin mesylate phamacokinetics in patients with solid tumors receiving repeated oral ketoconazole (KET). Presented at: 22nd EORTC-AACR-NCI Meeting. Berlin, Germany, 16-19 November 2010.
    • (2010) 22nd EORTC-AACR-NCI Meeting
    • Devriese, L.A.1    Wanders, J.2    Jenner, A.3
  • 42
    • 79551555821 scopus 로고    scopus 로고
    • Eribulin mesylate pharmacokinetics in patients with hepatic impairment
    • Abstract 2582
    • Witteveen P, Marchetti S, Mergui-Roelvink M, et al. Eribulin mesylate pharmacokinetics in patients with hepatic impairment. J. Clin. Oncol. 28(15), Abstract 2582 (2010).
    • (2010) J. Clin. Oncol , vol.28 , Issue.15
    • Witteveen, P.1    Marchetti, S.2    Mergui-Roelvink, M.3
  • 43
    • 79551561542 scopus 로고    scopus 로고
    • Phase Ib study of eribulin mesylate in combination with carboplatin in patients with advanced solid tumors
    • Abstract 2589
    • Swami U, Petrylak DP, Raftopoulos H, et al. Phase Ib study of eribulin mesylate in combination with carboplatin in patients with advanced solid tumors. J. Clin. Oncol. 28(15), Abstract 2589 (2010).
    • (2010) J. Clin. Oncol , vol.28 , Issue.15
    • Swami, U.1    Petrylak, D.P.2    Raftopoulos, H.3
  • 45
    • 77957594393 scopus 로고    scopus 로고
    • Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine
    • Cortes J, Vahdat L, Blum JL, et al. Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine. J. Clin. Oncol. 28, 3922-3928 (2010).
    • (2010) J. Clin. Oncol , vol.28 , pp. 3922-3928
    • Cortes, J.1    Vahdat, L.2    Blum, J.L.3
  • 46
    • 79551553908 scopus 로고    scopus 로고
    • Efficacy and safety of eribulin in Japanese patients (pts) with advanced breast cancer
    • Abstract 1081
    • Iwata H, Aogi K, Masuda N, et al. Efficacy and safety of eribulin in Japanese patients (pts) with advanced breast cancer. J. Clin. Oncol. 28(15), Abstract 1081 (2010).
    • (2010) J. Clin. Oncol , vol.28 , Issue.15
    • Iwata, H.1    Aogi, K.2    Masuda, N.3
  • 47
    • 77955893812 scopus 로고    scopus 로고
    • A Phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline and a taxane
    • Abstract CRA1004
    • Twelves C, Loesch D, Blum JL, et al. A Phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline and a taxane. J. Clin. Oncol. 28, Abstract CRA1004 (2010).
    • (2010) J. Clin. Oncol , vol.28
    • Twelves, C.1    Loesch, D.2    Blum, J.L.3
  • 48
    • 77950475001 scopus 로고    scopus 로고
    • Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer
    • Twelves C, Cortes J, Vahdat LT, Wanders J, Akerele C, Kaufman PA: Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer. Clin. Breast Cancer 10, 160-163 (2010).
    • (2010) Clin. Breast Cancer , vol.10 , pp. 160-163
    • Twelves, C.1    Cortes, J.2    Vahdat, L.T.3    Wanders, J.4    Akerele, C.5    Kaufman, P.A.6
  • 52
    • 79953152791 scopus 로고    scopus 로고
    • Eisai Inc. Halaven Prescibing Information
    • Eisai Inc. Halaven Prescibing Information (2010) www.halaven.com
    • (2010)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.