Pharmacogenomics of alcohol metabolism: Implications for legal testing

Clinical Chemistry and Laboratory Medicine

Volumn 49, Issue 1, 2011, Pages 9-11

  Lippi, Giuseppe ^a   Plebani, Mario ^b  

^a UNIVERSITY HOSPITAL OF PARMA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Alcohol; Metabolism; Pharmacogenomics; Testing

Indexed keywords

CYTOCHROME P450 2E1;

ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ALCOHOLISM; AMINO ACID SUBSTITUTION; CAR DRIVING; DRUNKEN DRIVING; EDITORIAL; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; LABORATORY TEST; MOTOR COORDINATION; MOTOR VEHICLE; NONHUMAN; PHARMACOGENOMICS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRAFFIC ACCIDENT;

ALCOHOL DRINKING; ETHANOL; HUMANS; PHARMACOGENETICS; SUBSTANCE ABUSE DETECTION;

EID: 79953148094     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.025     Document Type: Editorial

References (17)

1. Whitfield JB. Alcohol and gene interactions. Clin Chem Lab Med 2005;43:480-7. (Pubitemid 41460624)
2. Schwandt ML, Lindell SG, Chen S, Higley JD, Suomi SJ, Heilig M, et al. Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. Alcohol 2010;44:67-80.
3. Barr CS, Newman TK, Becker ML, Champoux M, Lesch KP, Suomi SJ, et al. Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress. Alcohol Clin Exp Res 2003;27:812-7. (Pubitemid 36583364)
4. Dick DM, Plunkett J, Wetherill LF, Xuei X, Goate A, Hesselbrock V, et al. Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample. Alcohol Clin Exp Res 2006;30:1101-10. (Pubitemid 43892898)
5. Schuckit MA, Wilhelmsen K, Smith TL, Feiler HS, Lind P, Lange LA, et al. Autosomal linkage analysis for the level of response to alcohol. Alcohol Clin Exp Res 2005;29:1976-82. (Pubitemid 41790835)
6. Ray LA, Hutchison KE. A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcohol Clin Exp Res 2004;28:1789-95. (Pubitemid 39665194)
7. Webb A, Lind PA, Kalmijn J, Feiler HS, Smith TL, Schuckit MA, et al. The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis. Alcohol Clin Exp Res 2011;35:1-9.
8. Joslyn G, Brush G, Robertson M, Smith TL, Kalmijn J, Schuckit M, et al. Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans. Proc Natl Acad Sci USA 2008;105:20368-73.
9. Hu W, Saba L, Kechris K, Bhave SV, Hoffman PL, Tabakoff B. Genomic insights into acute alcohol tolerance. J Pharmacol Exp Ther 2008;326:792-800.
10. Gemma S, Vichi S, Testai E. Individual susceptibility and alcohol effects: biochemical and genetic aspects. Ann 1st Super Sanita 2006;42:8-16. (Pubitemid 44174653)
11. Edenberg HJ. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 2007;30:5-13.
12. Jannetto PJ, Laleli-Sahin E, Wong SH. Pharmacogenomic genotyping methodologies. Clin Chem Lab Med 2004;42:1256-64. (Pubitemid 39600328)
13. Whitfield JB. Molecular biology and genetics in clinical chemistry and laboratory medicine. Clin Chem Lab Med 2010;48: 431-4.
14. Bianchi V, Arfini C, Helander A. Determination of carbohydrate-deficient transferrin (CDT) in Italy. Clin Chem Lab Med 2008;46:1759-62.
15. Jeppsson JO, Arndt T, Schellenberg F, Wielders JP, Anton RF, Whitfield JB, et al. International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardization of Carbohydrate-deficient Transferin (IFCC-WG-CDT). Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method. Clin Chem Lab Med 2007;45: 558-62.
16. Hannuksela ML, Liisanantti MK, Nissinen AE, Savolainen MJ. Biochemical markers of alcoholism. Clin Chem Lab Med 2007; 45:953-61. (Pubitemid 47424855)
17. Sakutata H, Suzuki T, Yasuda H, Ito T. Beverage-specific effects of ethanol consumption on its biological markers. Clin Chem Lab Med 2008;46:699-702. (Pubitemid 351749106)