Modeling industrial centrifugation of mammalian cell culture using a capillary based scale-down system

Biotechnology and Bioengineering

Volumn 108, Issue 5, 2011, Pages 989-998

  Westoby, Matthew ^a   Rogers, Jameson K ^a   Haverstock, Ryan ^a   Romero, Jonathan ^a   Pieracci, John ^a  

^a BIOGEN   (United States)

Author keywords

Centrifugation; Clarification efficiency; Disk stack centrifuge; Energy dissipation rate; Mammalian cell; Scale down

Indexed keywords

BIOPHARMACEUTICALS; CAPILLARY DEVICES; CENTRATE; CONTINUOUS-FLOW; DISK STACK CENTRIFUGE; ENERGY DISSIPATION RATE; INDUSTRIAL PROCESSS; LABORATORY SCALE; MAMMALIAN CELL CULTURE; MAMMALIAN CELLS; PILOT SCALE; PREDICTION ERRORS; PROCESS MODELING; RESOURCE REQUIREMENTS; SCALE-DOWN; SHEAR DEVICES;

ANIMAL CELL CULTURE; CELL CULTURE; CENTRIFUGATION; CENTRIFUGES; CLARIFIERS; DENSITY MEASUREMENT (SPECIFIC GRAVITY); ELECTRON ENERGY LOSS SPECTROSCOPY; ENERGY DISSIPATION; ENERGY DISSIPATORS; INDUSTRY; MAMMALS; TURBIDITY;

CONTINUOUS CELL CULTURE;

ARTICLE; CELL CULTURE; CENTRIFUGATION; INDUSTRY; MAMMAL; MODEL; TURBIDITY;

ANIMALS; CELL CULTURE TECHNIQUES; CENTRIFUGATION; CHO CELLS; CRICETINAE; CRICETULUS; PARTICLE SIZE;

MAMMALIA;

EID: 79953143765     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23051     Document Type: Article

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