Effect of shear on plasmid DNA in solution

Bioprocess Engineering

Volumn 20, Issue 1, 1999, Pages 7-13

  Levy, M S ^a   Collins, I J ^a   Yim, S S ^a   Ward, J M ^a   Titchener Hooker, N ^a   Ayazi Shamlou, P ^a   Dunnill, P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; PLASMID DNA;

ARTICLE; BIOPROCESS; CAPILLARY FLOW; DNA STRUCTURE; DNA SUPERCOILING; FLOW RATE; GENE THERAPY; IONIC STRENGTH; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; SHEAR STRESS;

EID: 0033067995     PISSN: 0178515X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004490050552     Document Type: Article

References (36)

1. 1. Davison, P.F.: The effect of hydrodynamic shear on the deoxyribonucleic acid from T2 and T4 bacteriophages. Proc. Natl. Acad. Sci. USA. 45 (1959) 1560-1568
2. 2. Levinthal, C.; Davison, P.F.: Degradation of deoxyribonucleic acid under hydrodynamic shearing forces. J. Mol. Biol. 3 (1961) 674-683
3. 3. Bowman, R.D.; Davidson, N.: Hydrodynamic shear breakage of DNA. Biopolymers 11 (1972) 2601-2624
4. 4. Adam, R.E.; Zimm, B. H.: Shear degradation of DNA. Nucleic. Acids. Res. 4 (1977) 1513-1537
5. 5. Reese, H.R.; Zimm, B.H.: Fracture of polymer chains in extensional flow: experiments with DNA, and a molecular-dynamics simulation. J. Chem. Phys. 92 (1990) 2650-2662
6. 6. Odell, J.A.; Taylor, M.A.: Dynamics and Thermomechanical stability of DNA in solution. Biopolymers. 34 (1994) 1483-1493
7. 7. Eastman, S.J.; Tousignant, J.D.; Lukason, M.J.; Murray, H.; Siegel, C.S.; Constantino, P.; Harris, D.J.; Cheng, S.H.; Scheule, R.K.: Optimisation of formulations and conditions for the aerosol delivery of functional cationic lipid:DNA complexes. Hum. Gene Ther. 8 (1997) 313-322
8. 8. Carlson, A.; Signs, M.; Lierman, L.; Boor, R.; Jim Jem, K.: Mechanical disruption of Escherichia coli for plasmid recovery. Biotechnol. Bioeng. 48 (1995) 303-315
9. 9. Crystal, R.G.: Transfer of genes to humans: early lessons and obstacles to success. Science. 270 (1995) 405-410
10. 10. Sokol, D.L.; Gewirtz, A.M.: Gene therapy: basic concepts and recent advances. Crit. Rev. Euk. Gene Exp. 6 (1996) 29-57
11. 11. Marquet, M.; Horr, N.A.; Meek, J.A.: Proccess development for the manufacture of plasmid DNA vectors for use in gene therapy. BioPharm. (1995) 26-37
12. 12. Hagerman, P.J.: Flexibility of DNA. Ann. Rev. Biophys. Biophys. Chem. 17 (1988) 265-286
13. 13. Lyubchenko, Y.L.; Shlyakhtenko, L.S.: Visualization of supercoiled DNA with atomic force microscopy in situ. Proc. Natl. Acad. Sci. USA. 94 (1997) 496-501
14. 14. Jackson, G.: Metabolic engineering of the toluene degradation pathway. Ph. D. thesis. University of London. 1995
15. 15. Jackson, G.; Sherestha, S.; Ward, J.M.: Metabolic engineering of the toluene degradation pathway. J. Cell. Biochem. S21A CIA (1995) 48
16. 16. Leyva, A.J.R.; Kelly, W.N.: Measurement of DNA in cultured human cells. Anal. Biochem. 62 (1974) 173-179
17. 17. Theodossiou, I.; Collins I.J.; Ward, J.M.; Thomas O.R.T.; Dunnill P.: The processing of a plasmid-based gene from E. coli. Primary recovery by filtration. Bioproc. Eng. 16 (1997) 175-183
18. 18. Thomas, C.R.; Dunnill, P.: Action of shear on enzymes: studies with catalase and urease. Biotechnol. Bioeng. 21 (1979) 2279-2302
19. 19. Sambrook, J.; Fritsch, E.F.; Maniatis, T.: Molecular Cloning-A laboratory manual, New York, Cold Spring Harbor Laboratory press 1989
20. 20. Haas, P.A.: Turbulent dispersion of aqueous drops in organic liquids. AIChE J. 33(1987) 987-995
21. 21. Hull, M.; Kitchener, J.A.: Interaction of spherical colloidal particles with planar surfaces. Trans. Faraday Soc. 65 (1969) 3093-3104
22. 22. Levich, V.G.: Physico-chemical hydrodynamics. Prentice Hall, New York 1962
23. 23. Fishman, D.M.; Patterson, G.D.: Light scattering studies of supercoiled and nicked DNA. Biopolymers. 38 (1996) 535-552
24. 24. Langowski J.; Giensen, U.: Configurational and dynamic properties of different length superhelical DNAs measured by dynamic light scattering. Biophys. Chem. 34 (1989) 9-18
25. 25. Schilick, T.; Li, B.; Olson, W.K.: The influence of salt on the structure and energetics of supercoiled DNA. Biophys. J. 67 (1994) 2146-2166
26. 26. Nguyen, T.Q.; Kausch, H.H.: Mechanochemical degradation in transient elongational flow. Adv. Polym. Sci. 100 (1992) 74-182
27. 27. Sacher, P.A.; Engel, P.A.; Bayer, R.G.: Mechanochemical aspects of repetitive impacts and sliding in polymers. J. Appl. Polym. 4 (1979) 1503-1514
28. 28. Hornby, S.: Downstream processing effects on microbial viability. phD thesis, University of London. 1995
29. 29. Oefner, P.J.; Hunicke-Smith S.P.; Chiang, L.; Dietrich, F.; Mulligan, J.; Davis, R.W.: Efficient random subcloning of DNA sheared in a recirculating point-sink flow system. Nucleic. Acids Res. 24 (1996) 3879-3886
30. 30. Hershey, A.; Burgii, E.: Molecular homogeneity of the deoxyribonucleic acid of phage T2. J. Mol. Biol. 2 (1960) 143-152
31. 31. Burgii, E.; Hershey, A.: Specificity and concentration limit in self-protection against mechanical breakage of DNA. J. Mol. Biol. 4 (1962) 313-315
32. 32. Thomas, C.R.; Nienow, A.W.; Dunnill, P.: Action of shear on enzymes: studies with alcohol dehydrogenase. Biotechnol. Bioeng. 21 (1979) 2263-2278
33. 33. Virkar, P.D.; Narendranathan T.J.; Hoare M.; Dunnill, P.: Studies of the effects of shear on globular proteins: extension to high shear fields and to pumps. Biotechnol Bioeng. 23 (1981) 425-429
34. 34. Maa, Y.; Hsu, C.C.: Protein denaturation by combined effect of shear and air-liquid interface. Biotechnol. Bioeng. 54 (1997) 503-512
35. 35. Lindahl, T.; Anderson, A.: Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid. Biochem. 11 (1972) 3618-3623
36. 36. Volkin, D.B.; Evans, R.K.; Bruner, M.: DNA vaccine formulations. International Patent Number WO 97/40839, 1997