Control circuitry for fear conditioning associated with Post-Traumatic Stress Disorder (PTSD)

Proceedings of the IEEE Conference on Decision and Control

Volumn , Issue , 2010, Pages 2541-2546

  Yang, Ruoting ^a   Sriram, K ^a   Doyle III, Francis J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BIFURCATION (MATHEMATICS); CHEMICAL ANALYSIS; ELECTRIC NETWORK ANALYSIS; FINITE DIFFERENCE METHOD; NEUROPHYSIOLOGY; PROTEINS; SENSITIVITY ANALYSIS; TIMING CIRCUITS; TRANSCRIPTION;

BIFURCATION ANALYSIS; CHEMICAL KINETIC MODEL; CONCENTRATION LEVELS; CONTROL CIRCUITRY; NUCLEUS ACCUMBENS; POSITIVE FEEDBACK LOOP; POSTTRAUMATIC STRESS DISORDER; REGULATORY PATHWAY;

FEEDBACK;

EID: 79953127633     PISSN: 07431546     EISSN: 25762370     Source Type: Conference Proceeding    
DOI: 10.1109/CDC.2010.5717136     Document Type: Conference Paper

References (22)

1. J. J. Vasterling, S. P. Proctor, M. J. Friedman, C. W. Hoge, T. Heeren, L. A. King, and D. W. King, "PTSD symptom increases in Iraq-deployed soldiers: Comparison with nondeployed soldiers and associations with baseline symptoms, deployment experiences, and postdeployment stress," J. Traum. Stress, vol. 23, pp. 41-51, 2010.
2. R. Yehuda, "Post-Traumatic Stress Disorder," N. Engl. J. Med., vol. 346, pp. 108-114, 2002.
3. A. Amstadter, N. Nugent, and K. Koenen, "Genetics of PTSD: Fear Conditioning as a Model for Future Research," Psychiatric Annals.
4. M. A. Pezze and J. Feldon, "Mesolimbic dopaminergic pathways in fear conditioning," Prog. Neurobiol., vol. 74, pp. 301-320, 2004.
5. D. E. Comings, B. G. Comings, D. Muhleman, G. Dietz, B. Shahbahrami, D. Tast, D. Knell, P. Kocsis, J. MacMurray, J. M. Tosk, J. Sverd, G. R., and S. D. Flanagan, "The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders," JAMA., vol. 266, pp. 1793-1800, 1991.
6. D. E. Comings, D. Muhleman, and R. Gysin, "Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: A study and replication," Biol. Psychiatry, vol. 40, pp. 368-372, 1996.
7. J.-H. Han, S. A. Kushner, A. P. Yiu, H.-L. Hsiang, T. Buch, A. Waisman, B. Bontempi, R. L. Neve, P. W. Frankland, and S. A. Josselyn, "Selective Erasure of a Fear Memory," Science, vol. 323, pp. 1492-1496, 2009.
8. E. Da Pozzo, C. Carmassi, S. Cuboni, A. Ciapparelli, M. L. Trincavelli, F. Mundo, D. Cesari, A. Lucacchini, C. Martini, and L. Dell'Osso, "P.4.a.015 Cyclic adenosine monophosphate (cAMP)-response element binding (CREB) protein levels in PTSD patients versus controls," Eur. Neuropsychopharmacol., vol. 18, pp. S486-S486, 2008.
9. J. W. A. Carlezon, R. S. Duman, and E. J. Nestler, "The many faces of CREB," Trends Neurosci., vol. 28, pp. 436-445, 2005.
10. É. Fernandez, R. Schiappa, J.-A. Girault, and N. L. Novère, "DARPP-32 Is a Robust Integrator of Dopamine and Glutamate Signals," PLoS Comput. Biol., vol. 2, p. e176, 2006.
11. M. Lindskog, M. Kim, M. A. Wikström, K. T. Blackwell, and J. H. Kotaleski, "Transient Calcium and Dopamine Increase PKA Activity and DARPP-32 Phosphorylation," PLoS Comput. Biol., vol. 2, p. e119, 2006.
12. A. Nishi, J. A. Bibb, G. L. Snyder, H. Higashi, A. C. Nairn, and P. Greengard, "Amplification of dopaminergic signaling by a positive feedback loop," PNAS, vol. 97, pp. 12840-12845, 2000.
13. S. Takahashi, T. Ohshima, A. Cho, T. Sreenath, M. J. Iadarola, H. C. Pant, Y. Kim, A. C. Nairn, R. O. Brady, P. Greengard, and A. B. Kulkarni, "Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling," PNAS, vol. 102, pp. 1737-1742, 2005.
14. H. C. Hemmings, A. C. Nairn, and P. Greengard, "DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate-regulated neuronal phosphoprotein. II. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1," J. Biol. Chem. , vol. 259, pp. 14491-14497, 1984.
15. J. A. Bibb, G. L. Snyder, A. Nishi, Z. Yan, L. Meijer, A. A. Fienberg, L.-H. Tsai, Y. T. Kwon, J.-A. Girault, A. J. Czernik, R. L. Huganir, H. C. Hemmings, A. C. Nairn, and P. Greengard, "Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons," Nature, vol. 402, pp. 669-671, 1999.
16. T. Nakano, T. Doi, J. Yoshimoto, and K. Doya, "A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity," PLoS Comput. Biol., vol. 6, p. e1000670, 2010.
17. Bhalla and U. S. Ravi Iyengar, "Emergent Properties of Networks of Biological Signaling Pathways," Science, vol. 283, pp. 381-387, 1999.
18. H. Usui, R. Inoue, O. Tanabe, Y. Nishito, M. Shimizu, H. Hayashi, H. Kagamiyama, and M. Takeda, "Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B" ([delta]) regulatory subunit in vitro and identification of the phosphorylation sites," FEBS Letters, vol. 430, pp. 312-316, 1998.
19. H. Schmidt and M. Jirstrand, "Systems Biology Toolbox for MATLAB: a computational platform for research in systems biology," Bioinformatics, vol. 22, pp. 514-515, 2006.
20. A. Saltelli, M. Ratto, T. Andres, F. Campolongo, J. Cariboni, D. Gatelli, M. Saisana, and S. Tarantola, Global Sensitivity Analysis: The Primer. Chichester, England: John Wiley & Sons, 2008.
21. B. N. Kholodenko, "Cell-signalling dynamics in time and space," Nat. Rev. Mol. Cell. Biol., vol. 7, pp. 165-176, 2006.
22. B. Ermentrout, Simulating, Analyzing, and Animating Dynamical Systems: A Guide to XPPAUT for Researchers and Students. Philadelphia, USA: SIAM, 2002.