Altered mesolimbic dopamine system in THC dependence

Current Neuropharmacology

Volumn 9, Issue 1, 2011, Pages 200-204

  Spiga, S ^a   Lintas, A ^b   Diana, M ^b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

Author keywords

Cannabinoids; Dopamine; Nucleus accumbens; Withdrawal

Indexed keywords

DELTA9(11) TETRAHYDROCANNABINOL; RIMONABANT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CANNABINOID DEPENDENCE; DENDRITIC SPINE; DETOXIFICATION; DOPAMINERGIC NERVE CELL; DRUG DEPENDENCE; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NUCLEUS ACCUMBENS; RAT; SUBSTANTIA NIGRA PARS COMPACTA; SYNAPTOGENESIS; VENTRAL TEGMENTUM;

EID: 79953125412     PISSN: 1570159X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157015911795017083     Document Type: Article

References (43)

1. Budney, A.J., Hughes, J.R. The cannabis withdrawal syndrome. Curr. Opin. Psychiatry, 2006, 19(3), 233-238.
2. Haney, M., Ward, A.S., Comer, S.D., Foltin, R.W., Fischman, M.W. Abstinence symptoms following oral THC administration to humans. Psychopharmacology, 1999, 141, 395-404.
3. Quickfall, J., Crockford, D. Brain neuroimaging in cannabis use: a review. J. Neuropsychiatry Clin. Neurosci., 2006, 18(3), 318-332.
4. 9-Tetrahydrocannabinol: studies on precipitated and abrupt withdrawal. J. Pharmacol. Exp. Ther., 1996, 278, 1290-1295.
5. Diana, M., Melis, M., Muntoni, A.L., Gessa, G.L. Mesolimbic dopaminergic decline after cannabinoid withdrawal. Proc. Natl. Acad. Sci. USA, 1998, 95(17), 10269-71023.
6. Gonzalez-Hernandez, T., Rodriguez, M. Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. J. Comp. Neurol., 2000, 421(1), 107-135.
7. Gonzalez, S., Fernandez-Ruiz, S.K., Nasser, J., Bennett, A., Zubaran, C., Foltin, R.W. Marijuana withdrawal in humans: effects of oral THC or divalproex. Neuropsychopharmacology, 2004, 29(1), 158-170.
8. Melis, M., Spiga, S., Diana, M. The dopamine hypothesis of drug addiction: hypodopaminergic state. Int. Rev. Neurobiol., 2005, 63, 101-154.
9. Pulvirenti, L., Diana, M. Drug dependence as a disorder of neural plasticity: focus on dopamine and glutamate. Rev. Neurosci., 2001, 12, 141-158.
10. Zito, K., Svoboda, K. Activity-dependent synaptogenesis in the adult Mammalian cortex. Neuron. 2002, 35(6), 1015-1017.
11. Zito, K., Knott, G., Shepherd, G.M., Shenolikar, S., Svoboda, K. Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. Neuron, 2004, 44(2), 321-334.
12. Robinson, T.E., Kolb, B. Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology, 2004, 47(Suppl. 1), 33-46.
13. Sklair-Tavron, L., Shi, W.X., Lane, S.B., Harris, H.W., Bunney, B.S., Nestler, E.J. Chronic morphine induces visibile changes in the morphology of mesolimbic dopamine neurons. Proc. Natl. Acad. Sci. USA, 1996, 93, 11202-11207.
14. Spiga, S., Serra, G.P., Puddu, M.C., Foddai, M., Diana, M. Morphine withdrawal-induced abnormalities in the VTA: confocal laser scanning microscopy. Eur. J. Neurosci., 2003, 17, 605-612.
15. Spiga, S., Puddu, M.C., Pisano, M., Diana, M. Morphine withdrawal- induced morphological changes in the nucleus accumbens. Eur. J. Neurosci., 2005, 22(9), 2332-2340.
16. Rinaldi-Carmona, M., Barth, F., Héaulme, M., Shire, D., Calandra, B., Congy, C., Martinez, S., Maruani, J., Néliat, G., Caput, D., Ferrar, P., Soubrie, P., Breliere, J.C., Fur, G.L. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett., 1994, 350(2-3), 240-244.
17. 9-tetrahydrocannabinol. Eur. J. Pharmacol., 1999, 376, 23-26.
18. Diana, M., Spiga, S., Acquas, E. Persistent and reversible morphine withdrawal-induced morphological changes in the nucleus accumbens. Ann. N. Y. Acad. Sci., 2006, 1074, 446-457.
19. Kolb, B., Gorny, G., Limebeer, C.L., Parker, L.A. Chronic treatment with Delta-9-tetrahydrocannabinol alters the structure of neurons in the nucleus accumbens shell and medial prefrontal cortex of rats. Synapse, 2006, 60(6), 429-436.
20. Paxinos, G., Watson, C. The Rat Brain in Stereotaxic Coordinates, 3rd Edn. Academic Press: Sydney, 1998.
21. Kolb, B., McClimans, J. Cryostat sectioning of Golgi-Cox tissue. Stain Technol., 1986, 61(6), 379-380.
22. Gonzalez, S., Fernandez-Ruiz, J., Di Marzo, V., Hernandez, M., Arevalo, C., Nicanor, C., Cascio, M.G., Ambrosio, E., Ramos, J.A. Behavioral and molecular changes elicited by acute dministration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence. Drug Alcohol Depend., 2004, 74(2), 159-170.
23. Davis, G.W. Homeostatic control of neural activity: from phenomenology to molecular design. Ann. Rev. Neurosci., 2006, 29, 307-323.
24. Mato, S., Robbe, D., Puente, N., Grandes, P., Manzoni, O.J. Presynaptic homeostatic plasticity rescues long-term depression after chronic Delta 9-tetrahydrocannabinol exposure. J. Neurosci., 2005, 25(50), 11619-11627.
25. Galve-Roperh, I., Aguado, T., Rueda, D., Velasco, G., Guzmán, M. Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development. Curr. Pharm. Des., 2006, 12(18), 2319-2325.
26. Galve-Roperh, I., Aguado, T., Palazuelos, J., Guzmán, M. The endocannabinoid system and neurogenesis in health and disease. Neuroscientist, 2007, 13(2), 109-114.
27. Melis, M., Pillolla, G., Bisogno, T., Minassi, A., Petrosino, S., Perra, S., Muntoni, A.L., Lutz, B., Gessa, G.L., Marsicano, G., Di Marzo, V., Pistis, M. Protective activation of the endocannabinoid system during ischemia in dopamine neurons. Neurobiol. Dis., 2006, 24(1), 15-27.
28. Melis, M., Pistis, M., Perra, S., Muntoni, A.L., Pillolla, G., Gessa, G.L. Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors. J. Neurosci., 2004, 24(1), 53-62.
29. Gerdeman, G., Lovinger, D.M. CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum. J. Neurophysiol., 2001, 85(1), 468-471.
30. Szabo, B., Wallmichrath, I., Mathonia, P., Pfreundtner, C. Cannabinoids inhibit excitatory neurotransmission in the substantia nigra pars reticulata. Neuroscience, 2000, 97(1), 89-97.
31. Bass, C.E., Griffin, G., Grier, M., Mahadevan, A., Razdan, R.K., Martin, B.R. SR-141716A-induced stimulation of locomotor activity. A structure-activity relationship study. Pharmacol. Biochem. Behav., 2002, 74(1), 31-40.
32. Rubino, T., Viganò, D., Zagato, E., Sala, M., Parolaro, D. In vivo characterization of the specific cannabinoid receptor antagonist, SR141716A: behavioral and cellular responses after acute and chronic treatments. Synapse, 2000, 35(1), 8-14.
33. Shepherd, G.M. Neurobiology, 3rd ed. Oxford University Press: Oxford, 1994
34. Gray, E.G. Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. J. Anat., 1959, 93, 420-433.
35. Rall, W. Electrophysiology of a dendritic neuron model. Biophys. J, 1962, (2 Pt 2), 145-167.
36. Wilson, C.J. Passive cable properties of dendritic spines and spiny neurons. J. Neurosci., 1984, 4(1), 281-297.
37. Hoffman, A.F., Oz, M., Caulder, T., Lupica, C.R. Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. J. Neurosci., 2003, 23(12), 4815-4820.
38. Koob, G.F., Le Moal, M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology, 2001, 24(2), 97-129.
39. Nestler, E.J., Aghajanian, G.K. Molecular and cellular basis of addiction. Science, 1997, 278, 58-63.
40. White, F.J. Synaptic regulation of mesocorticolimbic dopamine neurons. Annu. Rev. Neurosci., 1996, 19, 405-436.
41. Berridge, K.C., Robinson, T.E. What is the role of dopamine in reward: hedonic impact, reward learning or incentive salience? Brain Res. Rev., 1998, 28, 309-369.
42. Di Chiara, G. Drug addiction as dopamine-dependent associative learning disorder. Eur. J. Pharmacol., 1999, 30, 375(1-3), 13-30.
43. Koob, G.F., Le Moal, M. Drug abuse: hedonic homeostatic dysregulation. Science, 1997, 278, 52-58.