Prevalence and predictive value of ionized hypocalcemia among critically ill patients

Acta Anaesthesiologica Scandinavica

Volumn 47, Issue 10, 2003, Pages 1264-1269

  Hastbacka J ^a   Pettila V ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Critical illness; Ionized hypocalcemia; Mortality; Prediction

Indexed keywords

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HOSPITAL ADMISSION; HUMAN; HYPOCALCEMIA; IONIZATION; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; PROPHYLAXIS; REGRESSION ANALYSIS;

ADULT; AGED; CALCIUM; CRITICAL ILLNESS; FEMALE; HUMANS; HYPOCALCEMIA; IONS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; ROC CURVE; SENSITIVITY AND SPECIFICITY; SURVIVAL RATE;

EID: 0345305786     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1399-6576.2003.00236.x     Document Type: Article

References (41)

1. Broner CW, Stidham GL, Westenkirchner DF, Tolley EA. Hypomagnesemia and hypocalcemia as predictors of high mortality in critically ill paediatric patients. Crit Care Med 1990; 18: 921-8.
2. Baines PB, Thomson APJ, Fraser WD, Hart CA. Hypocalcaemia in severe meningococcal infections. Arch Dis Child 2000; 83: 510-3.
3. Zaloga GP, Chernow B, Cook D, Snyder R, Clapper M, O'Brian JT. Assessment of calcium homeostasis in the critically ill. The diagnostic pitfalls of the McLean-Hastings nomogram. Ann Surg 1985; 202: 587-94.
4. Zivin JR, Gooley T, Zager RA, Ryan MJ. Hypocalcemia: a pervasive metabolic abnormality in the critically ill. Am J Kidney Dis 2001; 37: 689-98.
5. Alberts DS, Serpick AA, Thompson WL. Hypocalcemia complicating acute leukemia. Med Pediatr Oncol 1975; 1: 289-95.
6. Aderka D, Schwartz D, Dan M, Levo Y. Bacteremic hypocalcemia. A comparison between the calcium levels of bacteremic and nonbacteremic patients with infection. Arch Intern Med 1987; 147: 232-6.
7. Woo P, Carpenter MA, Trunkney D. Ionized calcium: the effect of septic shock in the human. J Surg Res 1979; 26: 605-10.
8. Taylor B, Sibbald WJ, Edmonds MW, Holliday RL, Williams C. Ionized hypocalcemia in critically ill patients with sepsis. Can J Surg 1978; 21: 429-33.
9. Sibbald WJ, Sardesai V, Wilson RF. Hypocalcemia and nephrogenous cyclic AMP production in critically ill or injured patients. J Trauma 1977; 17: 677-84.
10. Zaloga GP, Chernow B. The multifactorial basis for hypocalcemia during sepsis. Studies of the parathyroid hormone-vitamin D axis. Ann Intern Med 1987; 107: 36-41.
11. Carlstedt F, Lind L, Rastad H, Stjernström H, Wide L, Ljunghall S. Parathyroid hormone and ionized calcium levels are related to the severity of illness and survival in critically ill patients. Eur J Clin Invest 1998; 28: 898-903.
12. Condon JR, Ives D, Knight MJ, Day J. The aetiology of hypocalcaemia in acute pancreatitis. Br J Surg 1975; 62:115-8.
13. Weir GC, Lesser PB, Drop LJ, Fischer JE, Warshaw AL. The hypocalcemia of acute pancreatitis. Ann Intern Med 1975; 83: 185-9.
14. Szyfelbein SK, Drop LJ, Martyn JAJ. Persistent ionized hypocalcemia in patients during resuscitation and recovery phases of body burns. Crit Care Med 1981; 9: 454-8.
15. Hadjis T, Grieff M, Lockhat D, Kaye M. Calcium metabolism in acute renal failure due to rhabdomyolysis. Clin Nephrol 1993; 39: 22-7.
16. Akmal M, Bishop JE, Telfer N, Norman AW, Massry SG. Hypocalcemia and hypercalcemia in patients with rhabdomyolysis with and without acute renal failure. J Clin Endocrinol Metab 1986; 63: 137-42.
17. Song SK, Karl IE, Ackerman JJH, Hotchkiss RS. Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis? Proc Natl Acad Sci USA 1993; 90: 3933-7.
18. Zaloga GP, Washburn D, Black KW, Prielipp R. Human sepsis increases lymphocyte intracellular calcium. Crit Care Med 1993; 21: 196-202.
19. Lind L, Carlstedt F, Rastad J et al. Hypocalcemia and parathyroid hormone secretion in critically ill patients. Crit Care Med 2000; 28: 93-9.
20. Zaloga GP. Hypocalcemia in critically ill patients. Crit Care Med 1992; 20: 251-62.
21. Sanchez GJ, Venkataraman PS, Pryor RW, Parker MK, Fry HD, Blick KE. Hypercalcitonemia and hypocalcemia in acutely ill children: Studies in serum calcium, blood ionized calcium, and calcium regulating hormones. J Pediatr 1989; 114: 952-6.
22. Gauthier B, Trachtman H, Di Carmine F et al. Hypocalcemia and hypercalcitonemia in critically ill children. Crit Care Med 1990; 18: 1215-9.
23. Auffant RA, Downs JB, Amick R. Ionized calcium concentration and cardiovascular function after cardiopulmonary bypass. Arch Surg 1981; 116: 1072-6.
24. Drop LJ. Ionized calcium, the heart, and hemodynamic function. Anesth Analg 1985; 64: 432-51.
25. Zaloga GP, Chernow B. Hypocalcemia in critical illness. JAMA 1986; 256: 1924-9.
26. Henderson SA, Graham HK, Mollan RAB. Serum and other calcium fractions in patients after severe musculoskeletal trauma. Clin Orthop 1992; 275: 306-11.
27. Cardenas-Rivero N, Chernow B, Stoiko MA, Nussbaum SR, Todres ID. Hypocalcemia in critically ill children. J Pediatr 1989; 114: 946-51.
28. Carlstedt F, Lind L, Wide L et al. Serum levels of parathyroid hormone are related to the mortality and severity of illness in patients in the emergency department. Eur J Clin Invest 1997; 27: 977-81.
29. Chernow B, Zaloga GP, McFadden E et al. Hypocalcemia in critically ill patients. Crit Care Med 1982; 10: 848-51.
30. Burchard KW, Gann DS, Colliton J, Forster J. Ionized calcium, parathormone, and mortality in critically ill surgical patients. Ann Surg 1990; 212: 543-9.
31. Desai TK, Carlson RW, Geheb MA. Prevalence and clinical implications of hypocalcemia in acutely ill patients in a medical intensive care setting. Am J Med 1988; 84: 209-14.
32. Wilson RF, Soullier G, Antonenko D. Ionized calcium levels in critically ill surgical patients. Am Surg 1979; 45: 485-90.
33. Randolph AG, Guyatt GH, Calvin JE, Doig G, Richardson WS. Understanding articles describing clinical prediction tools. Crit Care Med 1998; 26: 1603-12.
34. Ruttiman UE. Statistical approaches to development and validation of predictive instruments. Crit Care Clin 1994; 10: 19-35.
35. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982; 143: 29-36.
36. Cusack RJ, Rhodes A, Lochhead P et al. The strong ion gap does not have prognostic value in critically ill patients in a mixed medical/surgical adult ICU. Intensive Care Med 2002; 28: 864-9.
37. Oberhoffer M, Vogelsang H, Russvurm S, Hartung T, Reinhart K. Outcome prediction by traditional and new markers of inflammation in patients with sepsis. Clin Chem Lab Med 1999; 37: 363-8.
38. Harbarth S, Holeckova K, Froidevaux C et al. Diagnostic value of procalcitonin, interleukin-6 and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Resp Crit Care Med 2001; 164: 396-402.
39. Kollef MH, Eisenberg PR, Shannon W. A rapid assay for the detection of circulating D-dimer is associated with clinical outcomes among critically ill patients. Crit Care Med 1998; 26: 1054-60.
40. Pettilä V, Pentti J, Pettilä M, Takkunen O, Jousela I. Predictive value of antithrombin III and serum C-reactive protein concentration in critically ill patients with suspected sepsis. Crit Care Med 2002; 30: 271-5.
41. Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001; 286: 1754-8.