Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidis and human cells

Genome Biology

Volumn 12, Issue 3, 2011, Pages

  Cecil, Alexander ^a   Rikanović, Carina ^b   Ohlsen, Knut ^b   Liang, Chunguang ^a   Bernhardt, Jörg ^c   Oelschlaeger, Tobias A ^b   Gulder, Tanja ^b,d   Bringmann, Gerhard ^b   Holzgrabe, Ulrike ^b   Unger, Matthias ^b   Dandekar, Thomas ^a,e  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF GREIFSWALD   (Germany)

^d RWTH AACHEN UNIVERSITY   (Germany)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; CYTIDINE PHOSPHATE; CYTOCHROME P450; GUANOSINE PHOSPHATE; IQ 143; ISOQUINOLINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINAMIDE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; ANTIINFECTIVE AGENT; IQ 143 COMPOUND; IQ-143 COMPOUND; ISOQUINOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION PROFILING; GENE SEQUENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE METABOLISM; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; CELL LINE; CELL STRAIN HEK293; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGICAL STRESS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANTI-BACTERIAL AGENTS; CELL LINE; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; HEK293 CELLS; HUMANS; ISOQUINOLINES; METABOLIC NETWORKS AND PATHWAYS; NAPHTHALENES; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRESS, PHYSIOLOGICAL;

EID: 79953098927     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2011-12-3-r24     Document Type: Article

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