Low sensitivity of a whole-blood interferon-γ release assay for detection of active tuberculosis

Clinical Infectious Diseases

Volumn 44, Issue 1, 2007, Pages 69-73

  Dewan, Puneet K ^a   Grinsdale, Jennifer ^b   Kawamura, L Masae ^b  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

ADOLESCENT; ADULT; AGED; ARTICLE; ASSAY; BACTERIUM CULTURE; CHILD; CYTOKINE RELEASE; DEVICE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; HUMAN; INFANT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS; UNITED STATES;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FALSE NEGATIVE REACTIONS; HUMANS; INFANT; INFANT, NEWBORN; INTERFERON TYPE II; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; PREDICTIVE VALUE OF TESTS; REAGENT KITS, DIAGNOSTIC; SAN FRANCISCO; SENSITIVITY AND SPECIFICITY; TUBERCULIN TEST; TUBERCULOSIS; TUBERCULOSIS, PULMONARY;

EID: 33845708161     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/509928     Document Type: Article

References (19)

1. Pai M, Riley LW, Colford JM Jr. Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis 2004; 4:761-76.
2. Ferrara G, Losi M, Meacci M, et al. Routine hospital use of a new commercial whole blood interferon-γ assay for the diagnosis of tuberculosis infection. Am J Respir Crit Care Med 2005; 172:631-5.
3. Kang YA, Lee HW, Yoon HI, et al. Discrepancy between the tuberculin skin test and the whole-blood interferon gamma assay for the diagnosis of latent tuberculosis infection in an intermediate tuberculosis-burden country. JAMA 2005; 293:2756-61.
4. Mori T, Sakatani M, Yamagishi F, et al. Specific detection of tuberculosis infection: an interferon-gamma-based assay using new antigens. Am J Respir Crit Care Med 2004; 170:59-64.
5. Lee JY, Choi HJ, Park IN, et al. Comparison of two commercial interferon gamma assays for diagnosing Mycobacterium tuberculosis infection. Eur Respir J 2006; 28:24-30.
6. Tsiouris SJ, Coetzee D, Toro PL, Austin J, Stein Z, El-Sadr W. Sensitivity analysis and potential uses of a novel gamma interferon release assay for diagnosis of tuberculosis. J Clin Microbiol 2006; 44:2844-50.
7. Ravn P, Munk ME, Andersen AB, et al. Prospective evaluation of a whole-blood test using Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10 for diagnosis of active tuberculosis. Clin Diagn Lab Immunol 2005; 12:491-6.
8. Diagnostic standards and classification of tuberculosis in adults and children. Am J Respir Crit Care Med 2000; 161:1376-95.
9. Cellestis International. Quantiferon-TB Gold [package insert]. 2005. Available at: http://www.cellestis.com. Accessed 10 February 2006.
10. Centers for Disease Control and Prevention. Case definitions for infectious conditions under public health surveillance. MMWR Recomm Rep 1997;46(RR-10):1-55. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/ 00047449.htm. Accessed 20 August 2006.
11. Newcombe RG. Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med 1998; 17:857-72.
12. Mazurek GH, Jereb J, Lobue P, Iademarco MF, Metchock B, Vernon A. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR Recomm Rep 2005;54(RR-15):49-55.
13. Pai M, Kalantri S, Dheda K. New tools and emerging technologies for the diagnosis of tuberculosis: Part I. Latent tuberculosis. Expert Rev Mol Diagn 2006; 6:413-22.
14. Hussain R, Kaleem A, Shahid F, et al. Cytokine profiles using whole-blood assays can discriminate between tuberculosis patients and healthy endemic controls in a BCG-vaccinated population. J Immunol Methods 2002; 264:95-108.
15. Al-Attiyah R, Mustafa AS, Abal AT, Madi NM, Andersen P. Restoration of rhycobacterial antigen-induced proliferation and interferon-gamma responses in peripheral blood mononuclear cells of tuberculosis patients upon effective chemotherapy. FEMS Immunol Med Microbiol 2003; 38:249-56.
16. Carrara S, Vincenti D, Petrosillo N, Amicosante M, Girardi E, Goletti D. Use of a T cell-based assay for monitoring efficacy of antituberculosis therapy. Clin Infect Dis 2004; 38:754-6.
17. Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 2000; 161:5221-47.
18. Mahomed H, Hughes EJ, Hawkridge T, et al. Comparison of mantoux skin test with three generations of a whole blood IFN-gamma assay for tuberculosis infection. Int J Tuberc Lung Dis 2006; 10:310-6.
19. Pai M, O'Brien R. Tuberculosis diagnostics trials: do they lack methodological rigor? Expert Rev Mol Diagn 2006; 6:509-14.