Clinico-pathological correlations in fatal ischemic stroke. An immunohistochemical study of human brain penumbra

Romanian Journal of Morphology and Embryology

Volumn 52, Issue 1, 2011, Pages 29-38

  Arsene, D ^a   Vasilescu, Florina ^a   Toader, C ^b   Bǎlan, Adina ^a   Popa, C ^b   Ardeleanu, Carmen ^a  

^a VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY   (Romania)

^b CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Apoptosis; Immunohistochemistry; Inflammation; Penumbra; Stroke; Vascular convolutes

Indexed keywords

APAF1 PROTEIN, HUMAN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; CHYMASE; CYCLOOXYGENASE 2; FAS ANTIGEN; FAS PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR 2; PROTEIN BCL 2; PTGS2 PROTEIN, HUMAN; VASCULOTROPIN A;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN; BRAIN ISCHEMIA; CASE CONTROL STUDY; ENZYMOLOGY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; STROKE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD95; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BRAIN; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CASPASE 9; CHYMASES; CYCLOOXYGENASE 2; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; STROKE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; YOUNG ADULT;

ANIMALIA;

EID: 79953036369     PISSN: 12200522     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger VL, Rosamond W, Sacco R, Sørlie P, Stafford R, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J; American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Heart disease and stroke statistics -2010 update: a report from the American Heart Association, Circulation, 2010, 121(7):e46-e215.
2. Campbell J, Hilleman D, Recombinant peptides in thrombolysis, Semin Thromb Hemost, 2010, 36(5):529-536.
3. Ebinger M, De Silva DA, Christensen S, Parsons MW, Markus R, Donnan GA, Davis SM, Imaging the penumbra -strategies to detect tissue at risk after ischemic stroke, J Clin Neurosci, 2009, 16(2):178-187.
4. Liu S, Levine SR, The continued promise of neuroprotection for acute stroke treatment, J Exp Stroke Transl Med, 2008, 1(1):1-8.
5. Liu S, Levine SR, Winn HR, Targeting ischemic penumbra: part I -from pathophysiology to therapeutic strategy, J Exp Stroke Transl Med, 2010, 3(1):47-55.
6. Rogalewski A, Schneider A, Ringelstein EB, Schäbitz WR, Toward a multimodal neuroprotective treatment of stroke, Stroke, 2006, 37(4):1129-1136.
7. ] Lizasoain I, Cárdenas A, Hurtado O, Romera C, Mallolas J, Lorenzo P, Castillo J, Moro MA, Targets of cytoprotection in acute ischemic stroke: present and future, Cerebrovasc Dis, 2006, 21 Suppl 2:1-8.
8. Mitsios N, Gaffney J, Krupinski J, Mathias R, Wang Q, Hayward S, Rubio F, Kumar P, Kumar S, Slevin M, Expression of signaling molecules associated with apoptosis in human ischemic stroke tissue, Cell Biochem Biophys, 2007, 47(1):73-86.
9. Donnan GA, The 2007 Feinberg lecture: a new road map for neuroprotection, Stroke, 2008, 39(1):242-248.
10. Ferrer I, Planas AM, Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra, J Neuropathol Exp Neurol, 2003, 62(4):329-339.
11. Sairanen T, Karjalainen-Lindsberg ML, Paetau A, Ijäs P, Lindsberg PJ, Apoptosis dominant in the periinfarct area of human ischemic stroke -a possible target of antiapoptotic treatments, Brain, 2006, 129(Pt 1):189-199.
12. Nicholson DW, Caspase structure, proteolytic substrates, and function during apoptotic cell death, Cell Death Differ, 1999, 6(11):1028-1042.
13. Ranger AM, Malynn BA, Korsmeyer SJ, Mouse models of cell death, Nat Genet, 2001, 28(2):113-118.
14. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR, The BCL-2 family reunion, Mol Cell, 2010, 37(3):299-310.
15. Nakka VP, Gusain A, Mehta SL, Raghubir R, Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities, Mol Neurobiol, 2008, 37(1):7-38.
16. Kaneda K, Kashii S, Kurosawa T, Kaneko S, Akaike A, Honda Y, Minami M, Satoh M, Apoptotic DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina, Brain Res, 1999, 815(1):11-20.
17. Beck H, Plate KH, Angiogenesis after cerebral ischemia, Acta Neuropathol, 2009, 117(5):481-496.
18. Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, Greenberg DA, VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia, J Clin Invest, 2003, 111(12):1843-1851.
19. Krum JM, Mani N, Rosenstein JM, Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury, Exp Neurol, 2008, 212(1):108-117.
20. Renner O, Tsimpas A, Kostin S, Valable S, Petit E, Schaper W, Marti HH, Time-and cell type-specific induction of platelet-derived growth factor receptor-beta during cerebral ischemia, Brain Res Mol Brain Res, 2003, 113(1-2):44-51.
21. Krupinski J, Issa R, Bujny T, Slevin M, Kumar P, Kumar S, Kaluza J, A putative role for platelet-derived growth factor in angiogenesis and neuroprotection after ischemic stroke in humans, Stroke, 1997, 28(3):564-573.
22. Hiraga N, Adachi N, Liu K, Nagaro T, Arai T, Suppression of inflammatory cell recruitment by histamine receptor stimulation in ischemic rat brains, Eur J Pharmacol, 2007, 557(2-3):236-244.
23. Shen Y, Zhang S, Fu L, Hu W, Chen Z, Carnosine attenuates mast cell degranulation and histamine release induced by oxygen-glucose deprivation, Cell Biochem Funct, 2008, 26(3):334-338.
24. Lee H, Douglas-Jones AG, Morgan JM, Jasani B, The effect of fixation and processing on the sensitivity of oestrogen receptor assay by immunohistochemistry in breast carcinoma, J Clin Pathol, 2002, 55(3):236-238.
25. Duan SR, Wang JX, Wang J, Xu R, Zhao JK, Wang DS, Ischemia induces endoplasmic reticulum stress and cell apoptosis in human brain, Neurosci Lett, 2010, 475(3):132-135.
26. ] Ferrer I, Apoptosis: future targets for neuroprotective strategies, Cerebrovasc Dis, 2006, 21 Suppl 2:9-20.
27. Ferrer I, Friguls B, Dalfó E, Justicia C, Planas AM, Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat, Neuropathol Appl Neurobiol, 2003, 29(5):472-481.
28. Kriz J, Lalancette-Hébert M, Inflammation, plasticity and real-time imaging after cerebral ischemia, Acta Neuropathol, 2009, 117(5):497-509.
29. Biran V, Cochois V, Karroubi A, Arrang JM, Charriaut-Marlangue C, Héron A, Stroke induces histamine accumulation and mast cell degranulation in the neonatal rat brain, Brain Pathol, 2008, 18(1):1-9.
30. Marti HH, Risau W, Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors, Proc Natl Acad Sci U S A, 1998, 95(26):15809-15814.
31. Hayashi T, Abe K, Suzuki H, Itoyama Y, Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats, Stroke, 1997, 28(10):2039-2044.
32. Leventhal C, Rafii S, Rafii D, Shahar A, Goldman SA, Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma, Mol Cell Neurosci, 1999, 13(6):450-464.
33. Lennmyr F, Ata KA, Funa K, Olsson Y, Terént A, Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat, J Neuropathol Exp Neurol, 1998, 57(9):874-882.
34. Plate KH, Beck H, Danner S, Allegrini PR, Wiessner C, Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct, J Neuropathol Exp Neurol, 1999, 58(6):654-666.
35. Issa R, Krupinski J, Bujny T, Kumar S, Kaluza J, Kumar P, Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke, Lab Invest, 1999, 79(4):417-425.
36. Marti HJ, Bernaudin M, Bellail A, Schoch H, Euler M, Petit E, Risau W, Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia, Am J Pathol, 2000, 156(3):965-976.
37. Arsene D, Ardeleanu C, Vascular convolutes in the brain: a peculiar entity, Rom J Morphol Embryol, 2006, 47(1):37-41.
38. Madinier A, Bertrand N, Mossiat C, Prigent-Tessier A, Beley A, Marie C, Garnier P, Microglial involvement in neuroplastic changes following focal brain ischemia in rats, PLoS One, 2009, 4(12):e8101.
39. Veltkamp R, Rajapakse N, Robins G, Puskar M, Shimizu K, Busija D, Transient focal ischemia increases endothelial nitric oxide synthase in cerebral blood vessels, Stroke, 2002, 33(11):2704-2710.
40. Carmeliet P, Fibroblastic growth factor-1 stimulates branching and survival of myocardial arteries: a goal for therapeutic angiogenesis?, Circ Res, 2000, 87(3):176-178.
41. Issa R, AlQteishat A, Mitsios N, Saka M, Krupinski J, Tarkowski E, Gaffney J, Slevin M, Kumar S, Kumar P, Expression of basic fibroblast growth factor mRNA and protein in the human brain following ischaemic stroke, Angiogenesis, 2005, 8(1):53-62.
42. Ay I, Sugimori H, Finklestein SP, Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats, Brain Res Mol Brain Res, 2001, 87(1):71-80.
43. Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN, Lysko PG, Feuerstein GZ, Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury, Stroke, 1997, 28(6):1233-1244.
44. Maddahi A, Edvinsson L, Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway, J Neuroinflammation, 2010, 7:14.
45. Batti L, O'Connor JJ, Tumor necrosis factor-alpha impairs the recovery of synaptic transmission from hypoxia in rat hippocampal slices, J Neuroimmunol, 2010, 218(1-2):21-27.