The gap junction as a "biological Rosetta Stone": Implications of evolution, stem cells to homeostatic regulation of health and disease in the Barker hypothesis

Journal of Cell Communication and Signaling

Volumn 5, Issue 1, 2011, Pages 53-66

  Trosko, James E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Cell differentiation; Cell proliferation; Connexin; Gap junction

Indexed keywords

GAP JUNCTION PROTEIN;

AGING; APOPTOSIS; CANCER GENETICS; CELL ACTIVITY; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONFERENCE PAPER; EPIGENETICS; EVOLUTION; GAP JUNCTION; GENE EXPRESSION; GENE MUTATION; GENOTOXICITY; HOMEOSTASIS; HORMESIS; HUMAN; METAZOON; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN FUNCTION; STEM CELL; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

METAZOA; MUS MUSCULUS;

EID: 79953024882     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-010-0108-9     Document Type: Conference Paper

References (89)

1. L Armstrong K Tilgner G Saretzki SP Atkinson M Stokovic R Moreno S Przyborski M Lako 2010 Human induced pluripotent stem cell cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells Stem Cells 28 661 673 10.1002/stem.307 1:CAS:528:DC%2BC3cXms1yis7w%3D 20073085
2. M Asamoto N Hokaiwado T Murasaki T Shitai 2004 Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals Hepatology 40 205 210 10.1002/hep.20256 1:CAS:528:DC%2BD2cXmtlSgurs%3D 15239104 (Pubitemid 38868939)
3. DJ Barker 2004 The developmental origins of adult disease J Am Coll Nutr 236 588s 595s (Pubitemid 40096746)
4. C Borek L Sachs 1966 The difference in contact inhibition of cell replication between normal cells and cells transformed by different carcinogens Proc Natl Acad Sci USA 56 1705 1711 10.1073/pnas.56.6.1705 1:CAS:528: DyaF2sXmtlCksg%3D%3D 16591408
5. DE Brash JA Rudolph A Simon A Lin GJ McKenna HP Baden AJ Halperin J Pontén 1991 A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinomas Proc Natl Acad Sci USA 88 10124 10128 10.1073/pnas.88.22.10124 1:CAS:528:DyaK38XlsVKruw%3D%3D 1946433 (Pubitemid 21915787)
6. H Brody 1973 A systems view of man: implications for medicine, science and ethics Perspect Biol Med 17 71 92 1:STN:280:DyaE2c%2Fisl2gtg%3D%3D 4751534
7. G Bug H Gul K Schwarz H Pfeifer M Kampfmann X Zheng T Beissert S Boehrer D Hoelzer OG Ottmann M Ruthardt 2005 Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells Cancer Res 65 2537 2541 10.1158/0008-5472.CAN-04-3011 1:CAS:528:DC%2BD2MXjtVeqsrg%3D 15805245 (Pubitemid 40490047)
8. W Bursch F Oberhammer R Schulte-Hermann 1992 Cell death by apoptosis and its protective role against disease Trends Pharmacol Sci 13 245 251 10.1016/0165-6147(92)90077-J 1:STN:280:DyaK38zjs1eqtw%3D%3D 1631963
9. EJ Calabrese 2008 Hormesis: why it is important to toxicology and toxicologists Environ Toxicol Chem 27 1451 1474 10.1897/07-541.1 1:CAS:528:DC%2BD1cXnsl2ju70%3D 18275256 (Pubitemid 351961969)
10. A Cornish-Bowden 2006 Putting the systems back into systems 647 biology Perspect Biol Med 49 475 489 10.1353/pbm.2006.0053 1:CAS:528:DC%2BD28Xht1ymsL3P 17146133 (Pubitemid 44623359)
11. V Cruciani S-O Mikalsen 2005 The connexin gene family in mammals Biol Chem 386 325 332 10.1515/BC.2005.039 1:CAS:528:DC%2BD2MXjvV2itbY%3D 15899694 (Pubitemid 41447595)
12. M Csete 2005 Oxygen in the cultivation of stem cells Ann NY Acad Sci 1049 1 8 10.1196/annals.1334.001 1:CAS:528:DC%2BD2MXot1Cqu7o%3D 15965101 (Pubitemid 40967569)
13. De Feijter AW, Ray JS, Weghorst CM, Klaunig JE, Goodman JI, Chang CC, Ruch RJ, Trosko JE (1990) Infection of the rat liver epithelial cells with v-Ha-ras: Correlation between oncogene expression, gap junction communication, and tumorigenicity. Mol Carcinogen 3:54-67 (Pubitemid 20215295)
14. R Dobrowolski K Willecke 2009 Connexin-caused genetic diseases and corresponding mouse models Antioxid Redox Signal 11 283 295 10.1089/ars.2008. 2128 1:CAS:528:DC%2BD1cXhsFajsr7M 18831677
15. T Dobzhansky 1975 Nothing in biology makes sense except in the 651 light of evolution Am Biol Teach 35 125 129
16. AJ Duffield-Lillico CB Begg 2004 Reflections on the landmark studies of b-carotene supplementation J Natl Cancer Inst 96 1729 1731 10.1093/jnci/djh344 1:CAS:528:DC%2BD2cXhtVCrsrjJ 15572749 (Pubitemid 39654558)
17. GO Edwards SW Botchway G Hirst CW Wharton JK Chipman RA Meldrum 2004 Gap junction communication dynamics and the bystander effects from ultrasoft X-rays Br J Cancer 90 1450 1456 10.1038/sj.bjc.6601686 1:CAS:528:DC%2BD2cXis1ait70%3D 15054470 (Pubitemid 38586275)
18. P Eliasson JI Jonsson 2010 The hematopoietic stem cell niche: low in oxygen but a nice place to be J Cell Physiol 222 17 22 10.1002/jcp.21908 1:CAS:528:DC%2BD1MXhtlGgtrrP 19725055
19. PJ Fialkow 1979 Clonal origin of human tumours Am Rev Med 30 135 176 10.1146/annurev.me.30.020179.001031 1:STN:280:DyaL3M3otVGnsA%3D%3D
20. MS Forbes N Sperelakis 1982 Association between mitochondria and gap junctions in mammalian mycocardial cells Tissue Cell 14 25 37 10.1016/0040-8166(82)90004-0 1:STN:280:DyaL383isVOhsg%3D%3D 7089964 (Pubitemid 12040403)
21. ME Franks GR Macpherson WD Figg 2004 Thalidomide Lancet 363 1802 1811 10.1016/S0140-6736(04)16308-3 1:CAS:528:DC%2BD2cXksVanu7Y%3D 15172781 (Pubitemid 38698386)
22. DG Gibson JI Glass C Lartigue VN Noskov R-Y Chuang MA Alguire GA Benders MG Montague L Ma MM Moodie C Merryman S Vashee R Krishnakumar N Assad-Garcia C Andrews-Pfannkoch EA Denisova L Young Z-Q Qi TH Segall-Shapiro CH Calvey PP Parmar CA Hutchison III HO Smith JC Venter 2010 Creation of a bacterial cell controlled by a chemically-syntheized genome Science 329 52 56 10.1126/science.1190719 1:CAS:528:DC%2BC3cXotVeqsLg%3D 20488990
23. Y Guo L Einhorn M Kelley K Hirota J Yodoi R Reinhold H Scholer H Ramsey R Hromas 2004 Redox regulation of the embryonic stem cell transcription factor Oct4 by thioredoxin Stem Cell 22 259 264 10.1634/stemcells.22-3-259 (Pubitemid 38736610)
24. D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 663 100 57 70 10.1016/S0092-8674(00)81683-9 (Pubitemid 30046295)
25. CY Hsieh CC Chang 1999 Stem cell differentiation and reduction as a potential mechanism for chemoprevention of breast cancer Chin Pharm J 51 15 30 1:CAS:528:DyaK1MXktFSmt7o%3D
26. D Jaffe GT Bowden 1987 Ionizing radiation as an initiator: effects proliferation and promotion time on tumor incidence in mice Cancer Res 47 6692 6696 1:CAS:528:DyaL1cXptFShtw%3D%3D 3677101
27. WK Kaufman SA Mackenzie DG Kaufman 1987 Factors influencing the initiation by gamma rays of hepatocarcinogenesis in the rats Teratog Carcinogen Mutagen 7 551 556 10.1002/tcm.1770070606 (Pubitemid 18010763)
28. GJ Kelloff SM Lippman AJ Dannenberg CC Sigman HL Pearce BJ Reid E Szabo VC Jordan MR Spitz GB Mills VA Papadimitrakopoulou R Lotan BB Aggarwal RS Bresalier J Kim B Arun KH Lu ME Thomas HE Rhodes MA Brewer M Follen DM Shin HL Parnes JM Siegfried AA Evans WJ Blot W-H Chow PL Blount CC Maley KK Wang S Lam JJ Lee SM Dubinett PF Engstrom FL Meyskens Jr J O'Shaughnessy ET Hawk B Levin WG Nelson WK Hong AACR Task Force on Cancer Prevention 2006 Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer-a plan to move forward Clin Cancer Res 12 3661 3697 10.1158/1078-0432.CCR-06-1104 1:CAS:528: DC%2BD28XlvVSlsLw%3D 16778094 (Pubitemid 44000248)
29. DP Kelsell J Dunlop MB Hodgins 2001 Human diseases: clues to cracking the connexin code? Trends Cell Biol 11 2 6 10.1016/S0962-8924(00)01866-3 1:CAS:528:DC%2BD3MXnvFWi 11146276 (Pubitemid 32056180)
30. TJ King LH Fukushima TA Donlon AD Hieber KA Shimbukukuro JS Bertram 2000 Correlation between growth control, neoplastic potential and exogenous connexin43 expression of cell lines: implications for tumor progression Carcinogenesis 21 311 315 10.1093/carcin/21.2.311 1:CAS:528:DC%2BD3cXhs1Sju7o%3D 10657974 (Pubitemid 30098719)
31. WA Lenz 1988 Short history of thalidomide embryopathy Teratology 38 203 215 10.1002/tera.1420380303 1:STN:280:DyaL1M7ks1Kluw%3D%3D 3067415
32. CW Lo 1996 The role of gap junction membrane channels in development J Bioenerg Biomembr 28 379 385 10.1007/BF02110114 1:CAS:528:DyaK28XkvVaitbo%3D 8844335 (Pubitemid 26271370)
33. WR Loewenstein 1966 Permeability of membrane junctions Ann NY Acad Sci 137 441 472 10.1111/j.1749-6632.1966.tb50175.x 1:CAS:528:DyaF28XkslGqs70%3D 5229810
34. WR Loewenstein Y Kanno 1966 Intercellular communication and the control of tissue growth: lack of communication between 684 cancer cells Nature 209 1248 1249 10.1038/2091248a0 1:STN:280:DyaF2s%2FotFOhuw%3D%3D 5956321
35. CL Markert 1968 Neoplasia: a disease of differentiation Cancer Res 28 1908 1914 1:STN:280:DyaF1cvgvFarsA%3D%3D 5676741
36. CL Markert 1984 Genetic control of cell interactions in chimeras Dev Genet 4 267 279 10.1002/dvg.1020040405 (Pubitemid 14089619)
37. B Minsk K Illensee 1975 Normal genetically mosaic mice produced from malignant teratocarcinoma cells Proc Natl Acad Sci USA 72 3585 3589 10.1073/pnas.72.9.3585
38. A Mohyeldin T Garzon-Muvdi A Quinones-Hinojosa 2010 Oxygen in stem cell biology: a critical component of the stem cell niche Cell Stem Cell 7 150 161 10.1016/j.stem.2010.07.007 1:CAS:528:DC%2BC3cXhtVyrt77L 20682444
39. M Momiyama Y Omori Y Ishizaki Y Nishikawa T Tokairin J-I Ogawa K Enomoto 2003 Connexin26-mediated gap junctional communication reverses the malignant phenotype of MCF-7 breast cancer cells Cancer Sci 94 501 507 10.1111/j.1349-7006.2003.tb01473.x 1:CAS:528:DC%2BD3sXmsFWltrg%3D 12824874 (Pubitemid 36849713)
40. CA Moody LA Laimins 2010 Human papillomavirus oncoproteins: pathways to transformation Nat Rev Cancer 10 550 560 10.1038/nrc2886 1:CAS:528: DC%2BC3cXotFeltLo%3D 20592731
41. Y Nakamura N Yoshikawa I Hiroki K Sato K Ohtsuki CC Chang BL Upham JE Trosko 2005 β-Sitosterol, from psyllium seed husk (Plantago ovata Forsk), restores gap junctional intercellular communication in Ha-ras transfected rat liver cells Nutr Cancer 5 218 225 10.1207/s15327914nc5102-12 (Pubitemid 40734722)
42. National Research Council (2007) Toxicity testing in the 21st century: a vision and a strategy. National Academy Press, Washington, DC http://www.nas.edu
43. S Nicolai H Sies W Stahl 1997 Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human skin fibroblast Biochem Pharmacol 53 1553 1557 10.1016/S0006-2952(97)00096-8 1:CAS:528:DyaK2sXltVKlurk%3D 9260883 (Pubitemid 27356128)
44. PC Nowell 1976 The clonal evolution of tumor cell populations Science 194 23 28 10.1126/science.959840 1:STN:280:DyaE283ntFWmsw%3D%3D 959840
45. DM Panchision 2009 The role of oxygen in regulation neural stem cells in development and disease J Cell Physiol 220 562 568 10.1002/jcp.21812 1:CAS:528:DC%2BD1MXpsV2nt7g%3D 19441077
46. SA Pathel MC Simon 2008 Biology of hypoxia-inducible factor-2α in development and disease Cell Death Differ 15 628 634 10.1038/cdd.2008.17 (Pubitemid 351405065)
47. B Pierce 1974 Neoplasms, differentiation and mutations Am J Pathol 77 103 118 1:STN:280:DyaE2M%2FovVOitw%3D%3D 4447121
48. H Pitot YP Dragon 1991 Facts and theories concerning the mechanisms of carcinogenesis FASEB J 5 2280 2286 1:CAS:528:DyaK3MXksVels70%3D 1860619 (Pubitemid 21892904)
49. VR Potter 1974 Probabilistic aspects of the human cybernetic machine Perspect Biol Med 17 164 183 1:STN:280:DyaE2c%2FpvFChsA%3D%3D 4813113
50. VR Potter 1978 Phenotypic diversity in experimental hepatomas: concept ofpartially blocked ontogeny Br J Cancer 38 1 23 10.1038/bjc.1978.159 1:STN:280:DyaE1M%2FgtVajtQ%3D%3D 356869
51. A Prigione B Fauler R Lurz H Lehrach J Adjaye 2010 The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells Stem Cells 28 721 733 10.1002/stem.404 1:CAS:528:DC%2BC3cXms1yisL0%3D 20201066
52. Revel JP (1988) The oldest multicellular animal and its junctions. In: Hertzberg EL, Johnson R (eds) Gap junction. Alan Liss, New York, pp 135-149
53. JM Saul 2008 Did detoxification processes cause complex life to emerge? Lethaia 42 179 184 10.1111/j.1502-3931.2008.00126.x
54. JM Saul L Schwartz 2007 Cancer as a consequence of the rising level of oxygen in the Late Precambrian Lethaia 40 211 220 10.1111/j.1502-3931.2007. 00014.x (Pubitemid 350019756)
55. JL Schwartz 1996 The dual roles of nutrients as antioxidants and prooxidants: their effects of tumor cell growth J Nutr 126 1221S 1227S 1:CAS:528:DyaK28XhvFansbk%3D 8642460 (Pubitemid 26105662)
56. S Sell 1993 Cellular origin of cancer: de-differentiation or stem cell maturation arrest? Environ Health Perspect 101 15 26 10.2307/3431838 7516873 (Pubitemid 24096320)
57. Sheridan JD (1991) Cell communication and growth. In: DeMello WC (ed) Cell-to-cell communication. Plenum, New York, pp 187-222
58. K Shimano M Satake A Okaya J Kitanake N Kitanaka M Takemura M Sakagami N Terada T Tsujimura 2003 Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1 Am J Pathol 163 3 9 10.1016/S0002-9440(10)63624-3 1:CAS:528:DC%2BD3sXmtVWrt7w%3D 12819005 (Pubitemid 36759585)
59. U Silvan A Diez-Torre J Arluzea R Andrade M Silo J Arechaga 2009 Hypoxia and pluripotency in embryonic and embryonal carcinoma stem cell cell biology Differentiation 78 159 168 10.1016/j.diff.2009.06.002 1:CAS:528: DC%2BD1MXht1Squ7zK 19604622
60. MH Tai CC Chang M Kiupel JD Webster JE Trosko 2005 Oct-4 expression in adult stem cells: evidence in support of the stem cell theory of carcinogenesis Carcinogenesis 26 495 502 10.1093/carcin/bgh321 1:CAS:528:DC%2BD2MXmsVykug%3D%3D 15513931 (Pubitemid 40246573)
61. A Temme A Buchmann HD Gabriel E Nelles M Schwarz K Willecke 1997 High incidence of spontaneous and chemically induced liver cancers in mice deficient for connexin32 Curr Biol 7 713 716 10.1016/S0960-9822(06)00302-2 1:CAS:528:DyaK2sXmsVSisLo%3D 9285723 (Pubitemid 27408873)
62. JE Trosko 1998 Hierarchical and Cybernetic nature of biological systems and their relevance to homeostatic and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents Environ Health Perspect 106 331 339 10.2307/3433935 9539027 (Pubitemid 28196059)
63. JE Trosko 2001 Is the concept of 'tumor promotion' a useful paradigm? Mol Carcinog 30 131 137 10.1002/mc.1021 1:CAS:528:DC%2BD3MXjtVamsro%3D 11301473 (Pubitemid 32274076)
64. JE Trosko 2003 The role of stem cells and gap junctional communication in carcinogenesis J Biochem Mol Biol 36 43 48 1:CAS:528:DC%2BD3sXhtV2isb4%3D 12542974 (Pubitemid 36836255)
65. Trosko JE (2007) Concepts needed to understand potential health effects of chronic low-level radiation exposures: role of adult stem cells and modulated cell-cell communication. In: Shibata Y, Namba H, Suzuki K, Tomonaga M (eds) Radiation risk perspectives International Congress Series 1299. Elsevier, The Netherlands, pp 101-113
66. JE Trosko 2008 Human adult stem cells as the target cell for the initiation of carcinogenesis and for the generation of "cancer stem cells" Intl J Stem Cells 1 8 26 1:CAS:528:DC%2BD1MXhsVWksrnK
67. JE Trosko 2008 Role of diet and nutrition on the alteration of the quality and quantity of stem cells in human aging and the diseases of aging Curr Pharm Des 14 2707 2718 10.2174/138161208786264106 1:CAS:528:DC%2BD1cXhsVKhsr7L 18991690
68. Trosko JE, Chang CC (1988) Nongenotoxic mechanisms in carcinogenesis: role of inhibited intercellular communication. In: Hart RW, Hoerger FD (eds) Banbury Report 31: carcinogen risk assessment: new directions in the qualitative and quantitative aspects. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 139-170
69. JE Trosko RJ Ruch 1998 Cell-cell communication in carcinogenesis Front Biosci 3 208 236
70. JE Trosko RJ Ruch 2002 Gap junctions as therapeutic targets Curr Drug Targets 3 465 482 10.2174/1389450023347371 1:CAS:528:DC%2BD38Xos1yhtr8%3D 12448698 (Pubitemid 35339336)
71. Trosko JE, Suzuki K (2009) Adult stem cells, the Barker hypothesis, epigenetic events and low level radiation effects. In: Nakashima M, Takamura N, Tsukasaki K, Nagayama Y, Yamashita S (eds) Radiation health risk sciences. Springer, Tokyo, pp 216-226
72. Trosko JE, Tai M-H (2006) Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells. In: Dittmar T, Zaenker K (eds) Infection and inflammation: impacts on oncogenesis. Karger, Amsterdam, pp 45-65
73. JE Trosko BL Upham 2005 The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment Mutagenesis 20 81 92 10.1093/mutage/gei017 1:CAS:528:DC%2BD2MXjsFOmtLc%3D 15784692 (Pubitemid 40637806)
74. JE Trosko BL Upham 2010 A paradigm shift is required for the risk assessment of potential human health after exposure to low level chemical exposures: a response to the toxicity testing in the 21st Century Report Int J Toxicol 29 4 344 357 10.1177/1091581810371384 1:CAS:528:DC%2BC3cXhtVGktbzL 20634539
75. JE Trosko BL Upham 2010 Commentary on "Toxicology testing in the 21st Century: a vision and a strategy": stem cells and cell-cell communication as fundamental targets in assessing the potential toxicity of chemicals Human Exp Toxicol 29 21 29 10.1177/0960327109354663
76. JE Trosko CC Chang MR Wilson BL Upham T Hayashi M Wade 2000 Gap junctions and the regulation of cellular functions of stem cells during development and differentiation Methods 20 245 264 10.1006/meth.1999.0941 1:CAS:528: DC%2BD3cXhtVegtLc%3D 10671317 (Pubitemid 30130816)
77. JE Tseng BS Glisson FR Khuri, et al. 2001 Phase II study of the antiangiogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck Cancer 92 2364 2373 10.1002/1097-0142(20011101) 92:9<2364::AID-CNCR1584>3.0.CO;2-P 1:CAS:528:DC%2BD3MXotl2itb8%3D 11745292 (Pubitemid 33029081)
78. BL Upham JE Trosko 2005 A paradigm shift in the understanding of oxidative stress and its implications to exposures of low level ionizing radiation Acta Med Nagasaki 50 63 68 (Pubitemid 44670236)
79. BL Upham JE Trosko 2009 Carcinogenic tumor promotion, induced oxidative stress signaling, modulated gap junction function and altered gene expression Antioxid Redox Signal 11 297 308 10.1089/ars.2008.2146 1:CAS:528: DC%2BD1cXhsFWqu7fK 18834329
80. BL Upham KS Kang HY Cho JE Trosko 1997 Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells Carcinogenesis 18 37 42 10.1093/carcin/18.1.37 1:CAS:528:DyaK2sXhs1KhsLk%3D 9054587 (Pubitemid 28134614)
81. A VandenHooff 1989 An essay on basement membranes and their involvement in cancer Perspect Biol Med 32 3 401 413 1:STN:280:DyaL1M3mtlKitQ%3D%3D
82. OH Warburg 1956 On the origin of cancer cells Science 123 309 314 10.1126/science.123.3191.309 1:STN:280:DyaG28%2FltV2ktQ%3D%3D 13298683
83. IB Weinstein CS Gattoni P Kirschmeier, et al. 1984 Multistage carcinogenesis involves multiple genes and multiple mechanisms J Cell Physiol Suppl 3 127 137 10.1002/jcp.1041210416 1:STN:280:DyaL2c3msVyltw%3D%3D 6378934 (Pubitemid 14099981)
84. K Willecke J Eiberger J Degen D Eckhardt A Romauldi M Guldenagel U Duetsch G Sohl 2002 Structural and functional diversity of connexon genes in the mouse and human genome Biol Chem 383 725 737 10.1515/BC.2002.076 1:CAS:528:DC%2BD38XlvFelsrY%3D 12108537 (Pubitemid 34649891)
85. MR Wilson TW Close JE Trosko 2000 Cell population dynamics (apoptosis, mitosis and cell-cell communication) during disruption of homeostasis Exp Cell Res 254 257 268 10.1006/excr.1999.4771 1:CAS:528:DC%2BD3cXksl2qtg%3D%3D 10640424 (Pubitemid 30080582)
86. EC Wright 2004 Commentary on radiation-induced bystander effects Human Exp Toxicol 23 91 94 10.1191/0960327104ht424oa (Pubitemid 38380020)
87. H Yamasaki CCG Naus 1996 Role of connexion genes in growth control Carcinogenesis 17 1199 1213 10.1093/carcin/17.6.1199 1:CAS:528: DyaK28XjvFegtb4%3D 8681433 (Pubitemid 26196330)
88. LP Yotti CC Chang JE Trosko 1979 Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter Science 206 1089 1091 10.1126/science.493994 1:CAS:528:DyaL3cXltlWmtQ%3D%3D 493994 (Pubitemid 10208885)
89. H Zur Hausen 2003 SV40 in human cancers: endless tale? Int J Cancer 107 687 10.1002/ijc.11517 1:CAS:528:DC%2BD3sXovVGqu7s%3D 14566815 (Pubitemid 37339719)