Structural integrity of α-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability

RNA

Volumn 17, Issue 4, 2011, Pages 687-696

  Shin, Byung Sik ^a   Acker, Michael G ^b   Kim, Joo Ran ^a   Maher, Kathryn N ^a   Arefin, Shamsul M ^a   Lorsch, Jon R ^b   Dever, Thomas E ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

eIF5B; IF2; Subunit joining; Translation initiation

Indexed keywords

GLYCINE; GUANOSINE TRIPHOSPHATE; INITIATION FACTOR; INITIATION FACTOR 5B; METHIONINE TRANSFER RNA; RIBOSOME RNA; RNA 80S; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; CELL GROWTH; CONTROLLED STUDY; GENE MUTATION; HELIX H12; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RIBOSOME; RIGIDITY; RNA BINDING; RNA STABILITY; YEAST CELL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; EUKARYOTIC INITIATION FACTOR-2; EUKARYOTIC INITIATION FACTORS; GLYCINE; GUANOSINE TRIPHOSPHATE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; RIBOSOMES; RNA, TRANSFER, MET; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 79952997396     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2412511     Document Type: Article

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