The novel synthetic ether lipid inositol-C2-PAF inhibits phosphorylation of the tyrosine kinases Src and FAK independent of integrin activation in transformed skin cells

Biochemical Pharmacology

Volumn 81, Issue 8, 2011, Pages 985-995

  Semini, Geo ^a   Hildmann, Annette ^a   Reissig, Hans Ulrich ^b   Reutter, Werner ^c   Danker, Kerstin ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c Institut fuer Biochemie und Molekularbiologie   (Germany)

Author keywords

Adhesion; Glycosidated phospholipid; HaCaT cells; Ino C2 PAF; Integrin; Migration; SCC 25 cells

Indexed keywords

BETA1 INTEGRIN; ETHER LIPID; F ACTIN; FOCAL ADHESION KINASE; INOSITOL C2 PLATELET ACTIVATING FACTOR; INTEGRIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; ENZYME PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN CELL;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL ADHESION; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CYTOSKELETON; FLOW CYTOMETRY; FOCAL ADHESION KINASE 1; HUMANS; INTEGRINS; KERATINOCYTES; PHOSPHOLIPID ETHERS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 79952993953     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.02.002     Document Type: Article

References (34)

1. M.H. Runge, R. Andreesen, A. Pfleiderer, and P.G. Munder Destruction of human solid tumors by alkyl lysophospholipids J Natl Cancer Inst 64 1980 1301 1306 (Pubitemid 10109721)
2. D. Berkovic Cytotoxic etherphospholipid analogues Gen Pharmacol 31 1998 511 517 (Pubitemid 28458917)
3. C. Unger, H. Sindermann, M. Peukert, P. Hilgard, J. Engel, and H. Eibl Hexadecylphosphocholine in the topical treatment of skin metastases in breast cancer patients Prog Exp Tumor Res 34 1992 153 159
4. F. Mollinedo, J.L. Fernández-Luna, C. Gajate, B. Martín-Martín, A. Benito, and R. Martínez-Dalmau Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L) Cancer Res 57 1997 1320 1328 (Pubitemid 27152558)
5. G.A. Ruiter, M. Verheij, S.F. Zerp, and W.J. van Blitterswijk Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis Int J Radiat Oncol Biol Phys 49 2001 415 419 (Pubitemid 32120238)
6. C. Gajate, and F. Mollinedo Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts Blood 109 2007 711 719 (Pubitemid 46105973)
7. A. Wiese, T. Wieder, M. Mickeleit, S. Reinöhl, C.C. Geilen, and U. Seydel Structure-dependent effects of glucose-containing analogs of platelet activating factor (PAF) on membrane integrity Biol Chem 381 2000 135 144 (Pubitemid 30130737)
8. G. Arthur, and R. Bittman The inhibition of cell signaling pathways by antitumor ether lipids Biochim Biophys Acta 1390 1998 85 102 (Pubitemid 28122329)
9. A. Leroy, G.K. de Bruyne, L.C. Oomen, and M.M. Mareel Alkylphospholipids reversibly open epithelial tight junctions Anticancer Res 23 2003 27 32 (Pubitemid 36358496)
10. H. Eibl, and C. Unger Hexadecylphosphocholine: a new and selective antitumor drug Cancer Treat Rev 17 1990 233 242
11. C. Unger, and H. Eibl Hexadecylphosphocholine: preclinical and the first clinical results of a new antitumor drug Lipids 26 1991 1412 1417
12. M. Mickeleit, T. Wieder, K. Buchner, C.C. Geilen, J. Mulzer, and W. Reutter Glc-PC, a new type of glucosidic phospholipid Angew Chem Int Ed 34 1995 2667 2669
13. M. Mickeleit, T. Wieder, M. Arnold, C.C. Geilen, J. Mulzer, and W. Reutter A glucose-containing ether lipid (Glc-PAF) as an antiproliferative analogue of the platelet activating factor Angew Chem Int Ed 37 1998 351 353
14. P. Boukamp, R.T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham, and N.E. Fusenig Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line J Cell Biol 106 1988 761 771 (Pubitemid 18089976)
15. A. Fischer, D. Müller, M. Zimmermann-Kordmann, B. Kleuser, M. Mickeleit, and S. Laabs The ether lipid inositol-C2-PAF is a potent inhibitor of cell proliferation in HaCaT cells Chembiochem 7 2006 441 449
16. R.O. Hynes Integrins: versatility, modulation, and signaling in cell adhesion Cell 69 1992 11 25
17. R.O. Hynes Integrins: bidirectional, allosteric signaling machines Cell 110 2002 673 687 (Pubitemid 35283958)
18. M.D. Schaller, C.A. Otey, J.D. Hildebrand, and J.T. Parsons Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains J Cell Biol 130 1995 1181 1187
19. K. Danker, B. Gabriel, C. Heidrich, and W. Reutter Focal adhesion kinase pp125FAK and the beta 1 integrin subunit are constitutively complexed in HaCaT cells Exp Cell Res 239 1998 326 331 (Pubitemid 28366632)
20. L.M. Chen, D. Bailey, and C. Fernandez-Valle Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells J Neurosci 20 2000 3776 3784 (Pubitemid 30266239)
21. S.K. Mitra, and D.D. Schlaepfer Integrin-regulated FAK-Src signaling in normal and cancer cells Curr Opin Cell Biol 18 2006 516 523 (Pubitemid 44332916)
22. D. Vossmeyer, C. Kaufmann, K. Löster, W. Reutter, and K. Danker The cytoplasmic domain of the alpha1 integrin subunit influences stress fiber formation via the conserved GFFKR motif Exp Cell Res 256 2000 321 327 (Pubitemid 30211195)
23. S.K. Mitra, D.A. Hanson, and D.D. Schlaepfer Focal adhesion kinase: in command and control of cell motility Nat Rev Mol Cell Biol 6 2005 56 68 (Pubitemid 40064899)
24. D.C. Schallier, E.A. Bruyneel, G.A. Storme, P. Hilgard, and M.M. Mareel Antiinvasive activity of hexadecylphosphocholine in vitro Anticancer Res 11 1991 1285 1292
25. J.W. Slaton, J.A. Hampton, and S.H. Selman Exposure to alkyllysophospholipids inhibits in vitro invasion of transitional cell carcinoma J Urol 152 1994 1594 1598 (Pubitemid 24326324)
26. W.F. Steelant, J.L. Goeman, J. Philippé, L.C. Oomen, J. Hilkens, and M.-A Krzewinski-Recchi Alkyl-lysophospholipid 1-O-octadecyl-2-O-methyl- glycerophosphocholine induces invasion through episialin-mediated neutralization of E-cadherin in human mammary MCF-7 cells in vitro Int J Cancer 92 2001 527 536 (Pubitemid 32319426)
27. S. Van Slambrouck, C. Grijelmo, O. De Wever, E. Bruyneel, S. Emami, and C. Gespach Activation of the FAK-Src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion Int J Oncol 31 2007 1501 1508
28. T. Bartolmäs, T. Heyn, M. Mickeleit, A. Fischer, W. Reutter, and K. Danker Glucosamine-glycerophospholipids that activate cell-matrix adhesion and migration J Med Chem 48 2005 6750 6755 (Pubitemid 41504730)
29. M. Vicente-Manzanares, D.J. Webb, and A.R. Horwitz Cell migration at a glance J Cell Sci 118 2005 4917 4919 (Pubitemid 41672422)
30. M. Schober, S. Raghavan, M. Nikolova, L. Polak, H.A. Pasolli, and H.E. Beggs Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics J Cell Biol 176 2007 667 680 (Pubitemid 46333981)
31. M.D. Schaller, J.D. Hildebrand, J.D. Shannon, J.W. Fox, R.R. Vines, and J.T. Parsons Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src Mol Cell Biol 14 1994 1680 1688
32. X.D. Ren, W.B. Kiosses, D.J. Sieg, C.A. Otey, D.D. Schlaepfer, and M.A. Schwartz Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover J Cell Sci 113 2000 3673 3678
33. G.W. McLean, K. Brown, M.I. Arbuckle, A.W. Wyke, T. Pikkarainen, and E. Ruoslahti Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis Cancer Res 61 2001 8385 8389 (Pubitemid 33131110)
34. G.W. McLean, N.H. Komiyama, B. Serrels, H. Asano, L. Reynolds, and F. Conti Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression Genes Dev 18 2004 2998 3003 (Pubitemid 39658168)