Cholesterol biosynthesis regulation and protein changes in rat liver following treatment with fluvastatin

Toxicology Letters

Volumn 120, Issue 1-3, 2001, Pages 369-377

  Steiner, Sandra ^a   Gatlin, Christine L ^a   Lennon, John J ^a   McGrath, Andrew M ^a   Seonarain, Michael D ^a   Makusky, Anthony J ^a   Aponte, Angel M ^a   Esquer Blasco, Ricardo ^a   Anderson, N Leigh ^a  

^a Large Scale Biology Corporation   (United States)

Author keywords

Fluvastatin; Mass spectrometry; Pathway regulation; Proteomics; Rat liver; Two dimensional electrophoresis

Indexed keywords

CALCIUM; CHOLESTEROL; ENZYME; FLUINDOSTATIN; HEAT SHOCK PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; ISOPENTYL DIPHOSPHATE DELTA ISOMERASE; LIVER PROTEIN; PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CALCIUM HOMEOSTASIS; CARBOHYDRATE METABOLISM; CELL STRUCTURE; CHOLESTEROL SYNTHESIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INDUCTION; LIVER; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARBOHYDRATE METABOLISM; CHOLESTEROL; FATTY ACIDS, MONOUNSATURATED; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; LIPID METABOLISM; LIVER; MALE; PROTEINS; PROTEOME; RATS; RATS, INBRED F344;

EID: 0035977914     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00268-5     Document Type: Article

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