Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression

Human Reproduction

Volumn 22, Issue 4, 2007, Pages 1161-1167

  Tartakover Matalon, S ^a   Cherepnin, N ^a   Kuchuk, M ^a   Drucker, L ^a,b   Kenis, I ^a   Fishman, A ^a,b   Pomeranz, M ^a   Lishner, M ^a,b  

^a MEIR MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

HSP27; IGF IR; MMP2; Simvastatin; Trophoblast

Indexed keywords

GELATINASE A; HEAT SHOCK PROTEIN 27; SIMVASTATIN; SOMATOMEDIN C RECEPTOR; COLLAGEN; HEAT SHOCK PROTEIN; HSPB1 PROTEIN, HUMAN; LAMININ; MATRIGEL; MESSENGER RNA; PROTEOGLYCAN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; EXPLANT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PLACENTA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; TROPHOBLAST; WESTERN BLOTTING; ZYMOGRAPHY; BIOSYNTHESIS; CELL MOTION; CYTOLOGY; DRUG COMBINATION; FEMALE; GESTATIONAL AGE; METABOLISM; PREGNANCY;

BLOTTING, WESTERN; CELL MOVEMENT; COLLAGEN; DRUG COMBINATIONS; FEMALE; GESTATIONAL AGE; HEAT-SHOCK PROTEINS; HUMANS; LAMININ; MATRIX METALLOPROTEINASE 2; NEOPLASM PROTEINS; PLACENTA; PREGNANCY; PROTEOGLYCANS; RECEPTOR, IGF TYPE 1; RNA, MESSENGER; SIMVASTATIN; TROPHOBLASTS;

EID: 34347213418     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/del464     Document Type: Article

References (44)

1. Aldrian S, Trautinger F, Frohlich I, Berger W, Micksche M and Kindas-Mugge I (2002) Overexpression of Hsp27 affects the metastatic phenotype of human melanoma cells in vitro. Cell Stress Chaperones 7,177-185.
2. Aplin JD, Haigh T, Jones CJ, Church HJ and Vicovac L (1999) Development of cytotrophoblast columns from explanted first-trimester human placental villi: role of fibronectin and integrin alpha(5)beta(1). Biol Reprod 60(4):828-838.
3. Bellosta S, Ferri N, Berrini F, Paoletti R and Corsini A (2000) Non-lipid-related effects of statins. Ann Med 32,164-176.
4. Benahmed M, Reventos J and Saez JM (1983) Role of plasma lipoproteins in the function of steroidogenic tissues. Ann Endocrinol (Paris) 44,43-50.
5. Bischof P, Martelli M, Campana A, Itoh Y, Ogata Y and Nagase H (1995) Importance of matrix metalloproteinases in human trophoblast invasion. Early Pregnancy 1,263-269.
6. Bjorn SF, Hastrup N, Lund LR, Dano K, Larsen JF and Pyke C (1997) Co-ordinated expression of MMP-2 and its putative activator, MT1-MMP, in human placentation. Mol Hum Reprod 3(8):713-723
7. Calberg M, Dricu A, Blegen H, Wang M, Hjertman M, Zickert P, Hoog A and Larsson O (1996) Mevalonic acid is limiting for N-linked glycosilation and translocation of the insulin-like growth factor-1 receptor to the cell surface. J Biol Chem 271,17453-17462.
8. Chakraborty C, Gleeson LM, McKinnon T and Lala PK (2002) Regulation of human trophoblast migration and invasiveness. Can J Physiol Pharmacol 80,116-124.
9. Desager JP and Horsmans Y (1996) Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. Clin Pharmacokinet 31,348-371.
10. Dostal LA, Schardein JL and Anderson JA (1994) Developmental toxicity of the HMG-CoA reductase inhibitor, atorvastatin, in rats and rabbits. Teratology 50,387-394.
11. Geier A, Hemi R, Haimsohn M, Beery R and Karasik A (1997) Phosphorylation of A 27-kDa protein correlates with survival of protein-synthesis-inhibited MCF-7 cells. In Vitro Cell Dev Biol Anim 33,129-136.
12. Genbacev O, Schubach SA and Miller RK (1992) Villous culture of first trimester human placenta-model to study extravillous trophoblast (EVCT) differentiation. Placenta 13,439-461.
13. Genbacev O, Joslin R, Damsky CH, Polliotti BM and Fisher SJ (1996) Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. J Clin Invest 97,540-550
14. Gliemroth J, Zulewski H, Arnold H and Terzis AJ (2003) Migration, proliferation, and invasion of human glioma cells following treatment with simvastatin. Neurosurg Rev 26,117-124.
15. Hedges JC, Dechert MA, Yamboliev IA, Martin JL, Hickey E, Weber LA and Gerthoffer WT (1999) A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem 274,24211-24219.
16. Henson MC, Greene SJ, Reggio BC, Shi W and Swan KF (1997) Effects of reduced maternal lipoprotein-cholesterol viability on placental progesterone biosynthesis in the baboon. Endocrinology 138,1385-1391.
17. Hills FA, Elder MG, Chard T and Sullivan MH (2004) Regulation of human villous trophoblast by insulin-like growth factors and insulin-like growth factor-binding protein-1. J Endocrinol 183,487-496.
18. Hirano S, Shelden EA and Gilmont RR (2004) HSP27 regulates fibroblast adhesion, motility, and matrix contraction. Cell Stress Chaperones 9,29-37.
19. Hosokawa A, Bar-Oz B and Ito S (2003) Use of lipid-lowering agents (statins) during pregnancy. Can Fam Physician 49,747-749.
20. James JL, Stone PR and Chamley LW (2006) The effects of oxygen concentration and gestational age on extravillous trophoblast outgrowth in a human first trimester villous explant model. Hum Reprod 10, 2699-2705.
21. Kabir-Salmani M, Shiokawa S, Akimoto Y, Sakai K and Iwashita M (2004) The role of alpha(5)beta(1)-integrin in the IGF-I-induced migration of extravillous trophoblast cells during the process of implantation. Mol Hum Reprod 10,91-97.
22. Kenis I, Tartakover-Matalon S, Cherepnin N, Drucker L, Fishman A, Pomeranz M and Lishner M (2005) Simvastatin has deleterious effects on human first trimester placental explants. Hum Reprod 20,2866-2872.
23. Lacey H, Haigh T, Westwood M and Aplin JD (2002) Mesenchymally-derived IGF-I provides a paracrine stimulus for trophoblast migration. BioMed Central Dev Biol 2,5-12
24. Landry J and Huot J (1995) Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27. Biochem Cell Biol 73,703-707.
25. Larsson O (1996) HMG-CoA reductase inhibitors: role in normal and malignant cells. Crit Rev Oncol Hematol 22,197-212.
26. Luan Z, Chase AJ and Newby AC (2003) Statins inhibit secretion of metalloproteinases -1,-2,-3, and -9 from vascular smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol 23,769-775.
27. Malassine A and Cronier L (2002) Hormones and human trophoblast differentiation. Endocrine 19,3-11.
28. Mandl M, Haas J, Bischof P, Nohammer G and Desoye G (2002) Serum-dependent effects of IGF-I and insulin on proliferation and invasion of human first trimester trophoblast cell models. Histochem Cell Biol 117,391-399.
29. Masters BA, Palmoski MJ, Flint OP, Gregg RE,Wang-Iverson D and Durham SK (1995) In vitro myotoxicity of the 3-hydroxy-3-methylglytaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes. Toxicol Appl Pharmacol 131,163-174.
30. Matalon ST, Ornoy A, Fishman A, Drucker L and Lishner M (2005) The effect of 6-mercaptopurine on early human placental explants. Hum Reprod 20,1390-1397.
31. McMullen ME, Bryant PW, Glembotski CC, Vincent PA and Pumiglia KM (2005) Activation of p38 has opposing effects on the proliferation and migration of endothelial cells. J Biol Chem 280,20995-21003.
32. Mehlen P, Mehlen A, Godet J and Arrigo AP (1997) HSP27 as a switch between differentiation and apoptosis in murine embryonic stem cells. J Biol Chem 272,31657-31665.
33. Middleton B, Hatton J and White DA (1984) A mevalonate requirement for maintanance of fatty acid and protein synthesis during hormonally stimulated development of mammary gland in vitro. J Biol Chem 259,10124-10128.
34. Morrish DW, Linetsky E, Bhardwaj D, Li H, Dakour J, Marsh RG, Paterson MC and Godbout R (1996) Identification by subtractive hybridization of a spectrum of novel and unexpected genes associated with in vitro differentiation of human cytotrophoblast cells. Placenta 17,431-441.
35. Mott JD and Werb Z (2004) Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol 16(5),558-564.
36. Newby D, Marks L, Cousins F, Duffie E and Lyall F (2005) Villous explant culture: characterization and evaluation of a model to study trophoblast invasion. Hypertens Pregnancy 24,75-91.
37. Piotrowicz RS, Hickey E and Levin EG (1998) Heat shock protein 27 kDa expression and phosphorylation regulates endothelial cell migration. FASEB J 12,1481-1490.
38. Schenk B, Fernandez F and Waechter CJ (2001) The ins(ide) and out(side) of dolichyl phosphate biosynthesis and recycling in the endoplasmic reticulum. Glycobiology 11,61R-70R.
39. Siddals KW, Marshman E, Westwood M and Gibson JM (2004) Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways. J Biol Chem 279,38353-38359.
40. Siperstein MD (1984) Role of cholesterologenesis and isoprenoid synthesis in DNA replication and cell growth. Journal of Lipid Research 25,1462-1468.
41. Staun-Ram E, Goldman S, Gabarin D and Shalev E (2004) Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion. Reprod Biol Endocrinol 2,59.
42. Zhang D and Brodt P (2003) Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling. Oncogene 22,974-982
43. Zhang D, Samani AA and Brodt P (2003) The role of the IGF-I receptor in the regulation of matrix metalloproteinases, tumor invasion and metastasis. Horm Metab Res 35,802-808.
44. Zhang D, Bar-Eli M, Meloche S and Brodt P (2004) Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals. J Biol Chem 279,19683-19690.