Effects of GSTM1 in rheumatoid arthritis; results from the Swedish EIRA study

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Lundström, Emeli ^a   Hartshorne, Toinette ^b   Li, Kelly ^b   Lindblad, Staffan ^a   Wick, Marius C ^a,c   Bengtsson, Camilla ^a   Alfredsson, Lars ^a   Klareskog, Lars ^a   Padyukov, Leonid ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b APPLIED BIOSYSTEMS   (United States)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; GLUTATHIONE TRANSFERASE M1; HLA DR ANTIGEN; GLUTATHIONE S-TRANSFERASE M1; GLUTATHIONE TRANSFERASE;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; COPY NUMBER VARIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE DOSAGE; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; POLYMERASE CHAIN REACTION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RHEUMATOID ARTHRITIS; RISK FACTOR; SMOKING; SWEDEN; GENETICS;

NICOTIANA TABACUM;

ARTHRITIS, RHEUMATOID; GENE DOSAGE; GLUTATHIONE TRANSFERASE; HUMANS; POLYMERASE CHAIN REACTION; SWEDEN;

EID: 79952980145     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017880     Document Type: Article

References (29)

1. van der Helm-van Mil AH, Huizinga TW, (2008) Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Res Ther 10: 205.
2. Linn-Rasker SP, van der Helm-van Mil AH, van Gaalen FA, Kloppenburg M, de Vries RR, et al. (2006) Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles. Ann Rheum Dis 65: 366-371.
3. Padyukov L, Silva C, Stolt P, Alfredsson L, Klareskog L, (2004) A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 50: 3085-3092.
4. Pedersen M, Jacobsen S, Garred P, Madsen HO, Klarlund M, et al. (2007) Strong combined gene-environment effects in anti-cyclic citrullinated peptide-positive rheumatoid arthritis: a nationwide case-control study in Denmark. Arthritis Rheum 56: 1446-1453.
5. van der Helm-van Mil AH, Verpoort KN, Breedveld FC, Huizinga TW, Toes RE, et al. (2006) The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis Rheum 54: 1117-1121.
6. van der Helm-van Mil AH, Verpoort KN, le Cessie S, Huizinga TW, de Vries RR, et al. (2007) The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. Arthritis Rheum 56: 425-432.
7. Verpoort KN, Papendrecht-van der Voort EA, van der Helm-van Mil AH, Jol-van der Zijde CM, van Tol MJ, et al. (2007) Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles. Arthritis Rheum 56: 2913-2918.
8. Yun BR, El-Sohemy A, Cornelis MC, Bae SC, (2005) Glutathione S-transferase M1, T1, and P1 genotypes and rheumatoid arthritis. J Rheumatol 32: 992-997.
9. van der Helm-van Mil AH, Wesoly JZ, Huizinga TW, (2005) Understanding the genetic contribution to rheumatoid arthritis. Curr Opin Rheumatol 17: 299-304.
10. Olofsson P, Holmberg J, Tordsson J, Lu S, Akerstrom B, et al. (2003) Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet 33: 25-32.
11. Seidegard J, Pero RW, Markowitz MM, Roush G, Miller DG, et al. (1990) Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study. Carcinogenesis 11: 33-36.
12. Chenevix-Trench G, Young J, Coggan M, Board P, (1995) Glutathione S-transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset. Carcinogenesis 16: 1655-1657.
13. Perricone C, De Carolis C, Perricone R, (2009) Glutathione: a key player in autoimmunity. Autoimmun Rev 8: 697-701.
14. McLellan RA, Oscarson M, Alexandrie AK, Seidegard J, Evans DA, et al. (1997) Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity. Mol Pharmacol 52: 958-965.
15. Holla LI, Stejskalova A, Vasku A, (2006) Polymorphisms of the GSTM1 and GSTT1 genes in patients with allergic diseases in the Czech population. Allergy 61: 265-267.
16. Mattey DL, Hassell AB, Plant M, Dawes PT, Ollier WR, et al. (1999) Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope. Ann Rheum Dis 58: 164-168.
17. Mattey DL, Hutchinson D, Dawes PT, Nixon NB, Clarke S, et al. (2002) Smoking and disease severity in rheumatoid arthritis: association with polymorphism at the glutathione S-transferase M1 locus. Arthritis Rheum 46: 640-646.
18. Criswell LA, Saag KG, Mikuls TR, Cerhan JR, Merlino LA, et al. (2006) Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women. Ann Rheum Dis 65: 1163-1167.
19. Morinobu S, Morinobu A, Kanagawa S, Hayashi N, Nishimura K, et al. (2006) Glutathione S-transferase gene polymorphisms in Japanese patients with rheumatoid arthritis. Clin Exp Rheumatol 24: 268-273.
20. Keenan BT, Chibnik LB, Cui J, Ding B, Padyukov L, et al. (2010) Effect of glutathione S-transferase T1, M1, P1 and heme oxygenase-1 polymorphisms interactionswith heavy smoking on the risk of rheumatoid arthritis. Arthritis Rheum.
21. Norskov MS, Frikke-Schmidt R, Loft S, Tybjaerg-Hansen A, (2009) High-throughput genotyping of copy number variation in glutathione S-transferases M1 and T1 using real-time PCR in 20,687 individuals. Clin Biochem 42: 201-209.
22. Bekris LM, Shephard C, Peterson M, Hoehna J, Van Yserloo B, et al. (2005) Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset. Autoimmunity 38: 567-575.
23. Bohanec Grabar P, Logar D, Tomsic M, Rozman B, Dolzan V, (2009) Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis. Clin Exp Rheumatol 27: 229-236.
24. McDaniel DO, Alarcon GS, Pratt PW, Reveille JD, (1995) Most African-American patients with rheumatoid arthritis do not have the rheumatoid antigenic determinant (epitope). Ann Intern Med 123: 181-187.
25. Teller K, Budhai L, Zhang M, Haramati N, Keiser HD, et al. (1996) HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis: the "shared epitope" hypothesis may not apply. J Rheumatol 23: 1363-1368.
26. Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, et al. (2003) Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum Dis 62: 835-841.
27. Larsen A, Dale K, Eek M, (1977) Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh) 18: 481-491.
28. Ronnelid J, Wick MC, Lampa J, Lindblad S, Nordmark B, et al. (2005) Longitudinal analysis of citrullinated protein/peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis: anti-CP status predicts worse disease activity and greater radiological progression. Ann Rheum Dis 64: 1744-1749.
29. Wick M, Peloschek P, Bogl K, Graninger W, Smolen JS, et al. (2003) The "X-Ray RheumaCoach" software: a novel tool for enhancing the efficacy and accelerating radiological quantification in rheumatoid arthritis. Ann Rheum Dis 62: 579-582.