Characterization of a human glutathione S-Transferase μ cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity

Molecular Pharmacology

Volumn 52, Issue 6, 1997, Pages 958-965

  Mclellan, Roman A ^a   Oscarson, Mikael ^a   Alexandrie, Anna Karin ^a,b   Seidegård, Janeric ^c   Price Evans, David A ^d   Rannug, Agneta ^a,b   Ingelman Sundberg, Magnus ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d The General Directorate of Armed Forces Health Services   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE;

ARTICLE; BLADDER CANCER; CANCER RISK; CLINICAL ARTICLE; ENZYME ACTIVITY; ENZYME ASSAY; GENE DUPLICATION; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; HUMAN; LUNG CANCER; PRIORITY JOURNAL; RACE DIFFERENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RESTRICTION MAPPING; SAUDI ARABIA; SWEDEN; TANDEM REPEAT;

EID: 0031456155     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.6.958     Document Type: Article

References (40)

1. Hayes, J. D., and D. J. Pulford. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 30: 445-600 (1995).
2. Board, P. G. Biochemical genetics of glutathione-S-transferase in man. Am. J. Hum. Genet. 33:36-43 (1981).
3. b subunit cDNA. Nucleic Acids Res. 16:8541-8554 (1988).
4. Seidegård, J., and R. W. Pero. The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes. Hum. Genet. 69:66-68 (1985).
5. Widersten, M., W. R. Pearson, A. Engström, and B. Mannervik. Heterologous expression of the allelic variant μ-class glutathione transferases μ and ψ Biochem. J. 276:519-524 (1991).
6. Seidegård, J., W. R. Vorachek, R. W. Pero, and W. R. Pearson. Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl. Acad. Sci. USA 85:7293-7297 (1988).
7. Board, P., M. Coggan, P. Johnston, V. Ross, T. Suzuki, and G. Webb. Genetic heterogeneity of the human glutathione transferases: a complex of gene families. Pharmacol. Ther. 48:357-369 (1990).
8. Warholm, M., C. Guthenberg, and B. Mannervik. Molecular and catalytic properties of glutathione transferase μ from human liver: an enzyme efficiently conjugating epoxides. Biochemistry 22:3610-3617 (1983).
9. Seidegård, J., R. W. Pero, M. M. Markowitz, G. Roush, D. G. Miller, and E. J. Beattie. Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study. Carcinogenesis 11:33-36 (1990).
10. Alexandrie, A. K., M. Ingelman-Sundberg, J. Seidegård, G. Tornling, and A. Rannug. Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types. Carcinogenesis 15:1785-1790 (1994).
11. Hirvonen, A., K. Husgafvel-Pursiainen, S. Anttila, and H. Vainio. The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung. Carcinogenesis 14:1479-1481 (1993).
12. Kihara, M., M. Kihara, and K. Noda. Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure. Carcinogenesis 15:415-418 (1994).
13. Bell, D. A., J. A. Taylor, D. F. Paulson, C. N. Robertson, J. L. Mohler, and G. W. Lucier. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J. Natl. Cancer Inst. 85:1159-1164 (1993).
14. Brockmöller, J., R. Kerb, N. Drakoulis, B. Staffeldt, and I. Roots. Glutathione S-transferase M1, and its variants A and B as host factors of bladder cancer susceptibility: a case-control study. Cancer Res. 54:4103-4111 (1994).
15. Strange, R. C., B. Matharoo, G. C. Faulder, P. Jones, W. Cotton, J. B. Elder, and M. Deakin. The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma. Carcinogenesis 12:25-28 (1991).
16. Zhong, S., A. H. Wyllie, D. Barnes, C. R. Wolf, and N. K. Spurr. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder breast and colon cancer. Carcinogenesis 14:1821-1824 (1993).
17. Fryer, A. A., L. Zhao, J. Alldersea, M. D. Boggild, C. W. Perrett, R. N. Clayton, P. W. Jones, and R. C. Strange. The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas. Carcinogenesis 14:563-566 (1993).
18. Brockmöller, J., R. Kerb, N. Drakoulis, M. Nitz, and I. Roots. Genotype and phenotype of glutathione S-transferase class μ isoenzymes μ and ψ in lung cancer patients and controls. Cancer Res. 53:1004-1011 (1993).
19. Derrico, A., E. Taioli, X. Chen, and P. Vineis. Genetic metabolic polymorphisms and the risk of cancer - a review of the literature. Biomarkers 1:149-173 (1996).
20. Pearson, W. R., W. R. Vorachek, S. J. Xu, R. Berger, I. Hart, D. Vannais, and D. Patterson. Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. Am. J. Hum. Genet. 53: 220-233 (1993).
21. Ross, V. L., P. G. Board, and G. C. Webb. Chromosomal mapping of the human Mu class glutathione S-transferases to 1p13. Genomics 18:87-91 (1993).
22. Xu, S.-J., and W. R. Pearson. Characterization of the polymorphic human class mu GSTM1-0 deletion, in Glutathione S-Transferases: Structure, Function and Clinical Implications (N. P. E. Vermeulen, G. J. Mulder, H. Nieuwenhuyse, W. H. M. Peters, and P. J. Van Bladerer, eds.). Taylor & Francis Ltd., London, 227-238 (1996).
23. Islam, M. Q., A. Platz, J. Szpirer, C. Szpirer, G. Levan, and B. Mannervik. Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi. Hum. Genet. 82:338-342 (1989).
24. Inskip, A., J. Elexperu-Camiruaga, N. Buxton, P. S. Dias, J. MacIntosh, D. Campbell, P. W. Jones, L. Yengi, J. A. Talbot, R. C. Strange, and A. A. Fryer. Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A. Biochem. J. 312:713-716 (1995).
25. Evans, D. A. P., J. Seidegård, and N. Narayanan. The GSTM1 genetic polymorphism in healthy Saudi Arabians and Filipinos, and Saudi Arabians with coronary atherosclerosis. Pharmacogenetics 6:365-367 (1996).
26. Mannervik, B., Y. C. Awasthi, P. G. Board, J. D. Hayes, C. Di Ilio, B. Ketterer, I. Listowsky, R. Morgenstern, M. Muramatsu, W. R. Pearson, C. B. Pickett, K. Sato, M. Widersten, and C. R. Wolf. Nomenclature for human glutathione transferases. Biochem. J. 282:305-306 (1992).
27. Seidegård, J., J. W. De Pierre, W. Birberg, A. Pilotti, and R. W. Pero. Characterization of soluble glutathione transferase activity in resting mononuclear leukocytes from human blood. Biochem. Pharmacol. 33: 3053-3058 (1984).
28. Brockmöller, J., D. Gross, R. Kerb, N. Drakoulis, and I. Roots. Correlation between trans-stilbene oxide-glutathione conjugation activity and the deletion mutation in the glutathione S-transferase class Mu gene detected by polymerase chain reaction. Biochem. Pharmacol. 43:647-650 (1992).
29. Bauer, H. M., Y. Ting, C. E. Greer, J. C. Chambers, C. J. Tashiro, J. Chimera, A. Reingold, and M. M. Manos. Genital human papillomavirus infection in female university students as determined by a PCR-based method. JAMA 265:472-477 (1991).
30. Zhong, S., N. K. Spurr, J. D. Hayes, and C. R. Wolf. Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4. Biochem. J. 291:41-50 (1993).
31. Comstock, K. E., K. J. Johnson, D. Rifenbery, and W. D. Henner. Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4. J. Biol. Chem, 268:16958-16965 (1993).
32. Vorachek, W. R., W. R. Pearson, and G. S. Rule. Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus. Proc. Natl. Acad. Sci. USA 88:4443-4447 (1991).
33. Takahashi, Y., E. A. Campbell, Y. Hirata, T. Takayama, and I. Listowsky. A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5. J. Biol. Chem. 268:8893-8898 (1993).
34. Bertilsson, L., M.-L. Dahl, F. Sjöqvist, A. Åberg-Wistedt, M. Humble, I. Johansson, E. Lundqvist, and M. Ingelman-Sundberg. Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine. Lancet 341:63 (1993).
35. Kubota, T., S. Saitoh, T. Matsumoto, K. Narahara, Y. Fukushima, Y. Jinno, and N. Niikawa. Excess functional copy of allele at chromosomal region 11p15 may cause Wiedemann-Beckwith (EMG) syndrome. Am. J. Med. Genet. 49:378-383 (1994).
36. Mori, Y., Y. Miura, H. Takeuchi, Y. Igarashi, J. Sugiura, H. Saito, and Y. Oiso. Gene amplification as a cause of inherited thyroxine-binding globulin excess in two Japanese families. J. Clin. Endocrinol. Metab. 80:3758-3762 (1995).
37. Johansson, I., E. Lundqvist, L. Bertilsson, M.-L. Dahl, F. Sjöqvist, and M. Ingelman-Sundberg. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc. Natl. Acad. Sci. USA 90:11825-11829 (1993).
38. Aklillu, E., I. Persson, L. Bertilsson, I. Johansson, F. Rodrigues, and M. Ingelman-Sundberg. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multi-duplicated functional CYP2D6 alleles. J. Pharmacol. Exp. Ther. 278:441-446 (1996).
39. McLellan, R. A., M. Oscarson, J. Seidegård, D. A. P. Evans, and M. Ingelman-Sundberg. Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians. Pharmacogenetics 7:187-191 (1997).
40. Ingelman-Sundberg, M. Genetic polymorphism of drug metabolizing enzymes. Implications for toxicity of drugs and other xenobiotics. Arch. Toxicol. Suppl. 19:3-13 (1997).