The ghrelin signalling system is involved in the consumption of sweets

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Landgren, Sara ^a   Simms, Jeffrey A ^b   Thelle, Dag S ^c   Strandhagen, Elisabeth ^a   Bartlett, Selena E ^b   Engel, Jörgen A ^a   Jerlhag, Elisabet ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; GHRELIN; GHRELIN RECEPTOR; GHRELIN RECEPTOR 1A; SACCHARIN; SUCROSE; UNCLASSIFIED DRUG;

ADULT; ALCOHOL CONSUMPTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; FEMALE; FOOD PREFERENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SUGAR INTAKE; TASTE AVERSION; ANIMAL; C57BL MOUSE; COHORT ANALYSIS; DECISION MAKING; DRUG ANTAGONISM; DRUG EFFECT; DRUG SELF ADMINISTRATION; FEEDING BEHAVIOR; GENETICS; LONG EVANS RAT; METABOLISM; PHYSIOLOGY; TASTE;

ANIMALIA; MUS; RATTUS; RODENTIA;

ANIMALS; CHOICE BEHAVIOR; COHORT STUDIES; FEEDING BEHAVIOR; GHRELIN; HAPLOTYPES; HUMANS; MICE; MICE, INBRED C57BL; RATS; RATS, LONG-EVANS; RECEPTORS, GHRELIN; SACCHARIN; SELF ADMINISTRATION; SIGNAL TRANSDUCTION; SUCROSE; TASTE;

EID: 79952965604     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018170     Document Type: Article

References (51)

1. Volkow ND, Wang GJ, Maynard L, Jayne M, Fowler JS, et al. (2003) Brain dopamine is associated with eating behaviors in humans. Int J Eat Disord 33: 136-142.
2. Volkow ND, Li TK, (2004) Drug addiction: The neurobiology of behaviour gone awry. Nat Rev Neurosci 5: 963-970.
3. Reuter J, Raedler T, Rose M, Hand I, Gläscher J, et al. (2005) Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat Neurosci 8: 147-148.
4. Jerlhag E, Landgren S, Egecioglu E, Dickson SL, Engel JA, (2010) The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout mice. Alcohol In press, doi:10.1016/j.alcohol.2010.10.002.
5. Jerlhag E, Egecioglu E, Landgren S, Salomé N, Heilig M, et al. (2009) Requirement of central ghrelin signaling for alcohol reward. PNAS 106: 11318-11323.
6. Egecioglu E, Jerlhag E, Salomé N, Skibicka K, Haage D, et al. (2010) Ghrelin increases intake of rewarding food in rodents. Addict Biol 15: 304-311.
7. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660.
8. Tschöp M, Smiley DL, Heiman ML, (2000) Ghrelin induces adiposity in rodents. Nature 407: 908-913.
9. Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, et al. (2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest 116: 3229-3239.
10. Jerlhag E, Egecioglu E, Dickson S, Andersson M, Svensson L, et al. (2006) Ghrelin Stimulates Locomotor Activity and Accumbal Dopamine-Overflow via Central Cholinergic Systems in Mice: Implications for its Involvement in Brain Reward. Addict Biol 11: 45-54.
11. Jerlhag E, Egecioglu E, Dickson S, Douhan A, Svensson L, et al. (2007) Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addict Biol 12: 6-16.
12. Jerlhag E, Egecioglu E, Dickson SL, Svensson L, Engel JA, (2008) a-conotoxin MII-sensitive nicotinic acetylcholine receptors are involved in mediating the ghrelin-induced locomotor stimulation and dopamine overflow in nucleus accumbens. Eur Neuropsychopharmacol 18: 508-518.
13. Jerlhag E, Egecioglu E, Dickson SL, Engel JA, (2010) Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference. Psychopharmacology (Berl) 211: 415-422.
14. Kampov-Polevoy A, Eick C, Boland G, Khalitov E, Crews FT, (2004) Sweet liking, novelty seeking, and gender predict alcoholic status. Alcohol Clin Exp Res 28: 1291-1298.
15. Keskitalo K, Tuorila H, Spector TD, Cherkas LF, Knaapila A, et al. (2007) Same genetic components underlie different measures of sweet taste preference. Am J Clin Nutr 86: 1663-1669.
16. Belknap JK, Crabbe JC, Young ER, (1993) Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology (Berl) 112: 503-510.
17. Ramirez I, Sprott RL, (1978) Hunger and satiety in genetically obese mice (C57BL/6J-ob/ob). Physiol Behav 20: 257-264.
18. Kampov-Polevoy A, Garbutt JC, Khalitov E, (2003) Family history of alcoholism and response to sweets. Alcohol Clin Exp Res 27: 1743-1749.
19. Kampov-Polevoy A, Ziedonis D, Steinberg ML, Pinsky I, Krejci J, et al. (2003) Association between sweet preference and paternal history of alcoholism in psychiatric and substance abuse patients. Alcohol Clin Exp Res 27: 1929-1936.
20. Sinclair JD, Kampov-Polevoy A, Stewart R, Li TK, (1992) Taste preferences in rat lines selected for low and high alcohol consumption. Alcohol 9: 155-160.
21. Lemon CH, Brasser SM, Smith DV, (2004) Alcohol activates a sucrose-responsive gustatory neural pathway. J Neurophysiol 92: 536-544.
22. Berg C, Lappas G, Wolk A, Strandhagen E, Toren K, et al. (2009) Eating patterns and portion size associated with obesity in a Swedish population. Appetite 52: 21-26.
23. Berg CM, Lappas G, Strandhagen E, Wolk A, Toren K, et al. (2008) Food patterns and cardiovascular disease risk factors: the Swedish INTERGENE research program. Am J Clin Nutr 88: 289-297.
24. Strandhagen E, Berg C, Lissner L, Nunez L, Rosengren A, et al. (2010) Selection bias in a population survey with registry linkage: potential effect on socioeconomic gradient in cardiovascular risk. Eur J Epidemiol 25: 163-172.
25. Livak KJ, (1999) Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal 14: 143-149.
26. Landgren S, Jerlhag E, Zetterberg H, Gonzalez-Quintela A, Campos J, et al. (2008) Association of pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes with heavy alcohol use and body mass. Alcohol Clin Exp Res 32: 2054-2061.
27. Landgren S, Jerlhag E, Hallman J, Oreland L, Lissner L, et al. (2010) Genetic Variation of the Ghrelin Signaling System in Females With Severe Alcohol Dependence. Alcohol Clin Exp Res 34: 1519-1524.
28. Excoffier L, Slatkin M, (1995) Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 12: 921-927.
29. Larsson A, Jerlhag E, Svensson L, Söderpalm B, Engel JA, (2004) Is an a-conotoxin MII-sensitive mechanism involved in the neurochemical, stimulatory, and rewarding effects of ethanol? Alcohol 34: 239-250.
30. Jerlhag E, Grötli M, Luthman K, Svensson L, Engel JA, (2006) Role of the subunit composition of central nicotinic acetylcholine receptors for the stimulatory and dopamine-enhancing effects of ethanol. Alcohol Alcohol 41: 486-493.
31. Simms JA, Steensland P, Medina B, Abernathy KE, Chandler LJ, et al. (2008) Intermittent Access to 20% Ethanol Induces High Ethanol Consumption in Long-Evans and Wistar Rats. Alcohol Clin Exp Res 32: 1816-1823.
32. Steensland P, Simms JA, Holgate J, Richards JK, Bartlett SE, (2007) Varenicline, an a4b2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. PNAS 104: 12518-12523.
33. Simms JA, Bito-Onon JJ, Chatterjee S, Bartlett SE, (2010) Long-Evans rats acquire operant self-administration of 20% ethanol without sucrose fading. Neuropsychopharmacology 35: 1453-1463.
34. Landgren S, Simms JA, Hyytiä P, Engel JA, Bartlett SE, et al. (2010) Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. Addiction Biology In press, doi:10.1111/j.1369-1600.2010.00280.x.
35. Moulin A, Demange L, Berge G, Gagne D, Ryan J, et al. (2007) Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations. J Med Chem 50: 5790-5806.
36. Jerlhag E, (2008) Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine. Addict Biol 13: 358-363.
37. Skibicka K, Hansson C, Egecioglu E, Dickson SL, (2011) Role of ghrelin in food reward: Impact of ghrelin on on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression. Addiction Biology In press, doi:10.1111/j.1369-1600.2010.00294.x.
38. McCallum SE, Taraschenko OD, Hathaway ER, Vincent MY, Glick SD, (2011) Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats. Psychopharmacology (Berl) In press, doi:10.1007/s00213-010-2132-0.
39. Kampov-Polevoy A, Garbutt JC, Janowsky D, (1997) Evidence of preference for a high-concentration sucrose solution in alcoholic men. Am J Psychiatry 154: 269-270.
40. Disse E, Bussier AL, Veyrat-Durebex C, Deblon N, Pfluger PT, et al. (2010) Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content. Physiol Behav 101: 277-281.
41. Kampov-Polevoy A, Garbutt JC, Janowsky DS, (1999) Association between preference for sweets and excessive alcohol intake: a review of animal and human studies. Alcohol Alcohol 34: 386-395.
42. Carroll ME, Morgan AD, Anker JJ, Perry JL, Dess NK, (2008) Selective breeding for differential saccharin intake as an animal model of drug abuse. Behav Pharmacol 19: 435-460.
43. Larsson A, Engel JA, (2004) Neurochemical and behavioral studies on ethanol and nicotine interactions. Neurosci Biobehav Rev 27: 713-720.
44. Davis KW, Wellman PJ, Clifford PS, (2007) Augmented cocaine conditioned place preference in rats pretreated with systemic ghrelin. Regul Pept 140: 148-152.
45. Wellman PJ, Davis KW, Nation JR, (2005) Augmentation of cocaine hyperactivity in rats by systemic ghrelin. Regul Pept 125: 151-154.
46. Tessari M, Catalano A, Pellitteri M, Di Francesco C, Marini F, et al. (2007) Correlation between serum ghrelin levels and cocaine-seeking behaviour triggered by cocaine-associated conditioned stimuli in rats. Addict Biol 12: 22-29.
47. Keen-Rhinehart E, Bartness TJ, (2005) Peripheral ghrelin injections stimulate food intake, foraging, and food hoarding in Siberian hamsters. Am J Physiol Regul Integr Comp Physiol 288: R716-722.
48. Malik S, McGlone F, Bedrossian D, Dagher A, (2008) Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 7: 400-409.
49. Kaur S, Ryabinin AE, (2010) Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin-containing neurons. Alcohol Clin Exp Res 34: 1525-1534.
50. Jiang H, Betancourt L, Smith RG, (2006) Ghrelin Amplifies Dopamine Signaling by Crosstalk Involving Formation of GHS-R/D1R Heterodimers. Mol Endocrinol 20: 1772-1785.
51. Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW, (2003) High constitutive signaling of the ghrelin receptor- identification of a potent inverse agonist. Mol Endocrinol 17: 2201-2210.