The association between abdominal visceral fat and carotid stiffness is mediated by circulating inflammatory markers in uncomplicated type 2 diabetes

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 3, 2005, Pages 1495-1501

  Diamant, Michaela ^a,b   Lamb, Hildo J ^b   Van De Ree, Marcel A ^b   Endert, Edwin L ^b   Groeneveld, Ymte ^b   Bots, Michiel L ^c   Kostense, Piet J ^a   Radder, Jasper K ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; HEMOGLOBIN; INTERLEUKIN 6; LIVER PROTEIN;

ADIPOSE TISSUE; ADULT; ARTERY DILATATION; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; BODY FAT; BODY MASS; CAROTID ARTERY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCOSYLATION; HUMAN; MALE; MEASUREMENT; MULTIVARIATE ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; ULTRASOUND; VISCERA; ABDOMEN; BLOOD; BODY COMPOSITION; CAROTID ARTERY DISEASE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; OBESITY; PATHOLOGY;

ABDOMEN; ADIPOSE TISSUE; BIOLOGICAL MARKERS; BODY COMPOSITION; C-REACTIVE PROTEIN; CAROTID ARTERY DISEASES; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INTERLEUKIN-6; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; VISCERA;

EID: 15944371339     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1579     Document Type: Article

References (42)

1. Safar ME, Levy BI, Struijker-Boudier H 2003 Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular disease. Circulation 107:2864-2869
2. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, Ducimetiere P, Benetos A 2001 Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37:1236-1241
3. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG 2002 Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 106:2085-2090
4. Nichols WW, O'Rourke MF 1998 McDonald's blood flow in arteries: theoretical, experimental and clinical principles. 4th ed. London: Edward Arnold
5. Wilkinson IB, Franklin SS, Cockcroft JR 2004 Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology. Hypertension 44:112-116
6. Salomaa V, Riley W, Kark JD, Nardo C, Folsom A 1995 Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study. Circulation 91:1432-1443
7. Van Popele NM, Westendorp IC, Bots ML, Reneman RS, Hoeks AP, Hofman A, Grobbee DE, Witteman JC 2000 Variables of the insulin resistance syndrome are associated with reduced arterial distensibility in healthy nondiabetic middle-aged women. Diabetologia 43:665-672
8. Sutton-Tyrrel K, Newman A, Simonskk EM, Havlik R, Pahor M, Lakatta E, Spurgeon H, Vaitkevicius P 2001 Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition. Hypertension 38:429-433
9. Festa A, D'Agostino Jr R, Howard G, Mykkanen L, Tracy RP, Haffner SM 2000 Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102:42-47
10. Lemieux I, Pascot A, Prud'homme D, Aiméras N, Bogaty P, Nadeau A, Bergeron J, Després J-P 2001 Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vasc Biol 21:961-967
11. Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V 2000 Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148:209-214
12. Abramson JL, Weintraub WS, Vaccarino V 2002 Association between pulse pressure and C-reactive protein among apparently healthy US adults. Hypertension 39:2085-2090
13. Chae CU, Lee RT, Rifai N, Ridker PM 2001 Blood pressure and inflammation in apparently healthy men. Hypertension 38:399-403
14. O'Rourke MF, Staessen JA, Vlachopoulos C, Duprex D, Plante GE 2002 Clinical applications of arterial stiffness; definitions and reference values. Am J Hypertens 15:426-444
15. Blake GJ, Ridker PM 2001 Novel clinical markers of vascular wall inflammation. Circ Res 89:763-771
16. Fried SK, Bunkin DA, Greenberg AS 1998 Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83:847-850
17. Wildman RP, Mackey RH, Bostom A, Thompson T, Sutton-Tyrrell K 2003 Measures of obesity are associated with vascular stiffness in young and older adults. Hypertension 42:468-473
18. Alberti KG, Zimmet PZ for the WHO Consultation 1998 Definition, diagnosis and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation. Diabetic Med 15:539-553
19. Ewing D, Clarke B 1982 Diagnosis and management of diabetic autonomic neuropathy. Br Med J 285:916
20. Reneman RS, Van Merode T, Hick P, Muytjens AM, Hoeks AP 1986 Age-related changes in carotid artery wall properties in men. Ultrasound Med Biol 12:465-471
21. Westendorp ICD, In't Veld BA, Bots ML, Akkerhuis JM, Hofman A, Grobbee DE, Witteman JCM 1999 Hormone replacement therapy and intimamedia thickness of the common carotid artery: The Rotterdam Study. Stroke 30:2562-2567
22. Elbers JMH, Haumann G, Asscheman H, Seidell JC, Gooren LJG 1997 Reproducibility of fat area measurements in young, non-obese subjects by computerized analysis of magnetic resonance images. Int J Obes 21:1121-1129
23. Doggen CJM, Berckmans RJ, Sturk A, Manger Cats V, Rosendaal FR 2000 C-reactive protein, cardiovascular risk factors and the association with myocardial infarction in men. J Intern Med 248:406-414
24. Matthews DR, Hosker AS, Rudenski AS, Naylor BA, Treacher DF, Turner RC1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
25. Toto-Moukouo JJ, Achimastos A, Asmar RG, Hugues CJ, Safar ME 1986 Pulse wave velocity in patients with obesity and hypertension. Am Heart J 112:136-140
26. Taquet A, Bonithon-Kopp C, Simon A, Levenson J, Scarabin Y, Malmejac A, Ducimetiere P, Guize L 1993 Relations of cardiovascular risk factors to aortic pulse wave velocity in asymptomatic middle-aged women. Eur J Epidemiol 9:298-306
27. Ferreira I, Snijder MB, Twisk JW, van Mechelen W, Kemper HC, Seidell JC, Stehouwer CD 2004 Central fat mass versus peripheral fat and lean mass: opposite (adverse versus favorable) associations with arterial stiffness? The Amsterdam Growth and Health Longitudinal Study. J Clin Endocrinol Metab 89:2632-2639
28. Hegazi RA, Sutton-Tyrrell K, Evans RW, Kuller LH, Belle S, Yamamoto M, Edmundowicz D, Kelley DE 2003 Relationship of adiposity to subclinical atherosclerosis in obese patients with type 2 diabetes. Obes Res 11:1597-1605
29. Steinberg HO, Baron AD 2002 Vascular function, insulin resistance and fatty acids. Diabetologia 45:623-634
30. Ulrich P, Cerami A 2001 Protein glycation, diabetes, and aging. Recent Prog Horm Res 56:1-21
31. Singhal A, Farooqi IS, Cole TJ, O'Rahilly S, Fewtrell M, Kattenhorn M, Lucas A, Deanfield J 2002 Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 106:1919-1924
32. Satta J, Laurila A, Paakko P, Haukipuro K, Sormunen R, Parkkila S, Juvonen T 1998 Chronic inflammation and elastin degradation in abdominal aortic aneurysm disease: an immunohistochemical and electron microscopic study. Eur J Vasc Endovasc Surg 15:313-319
33. Wellen KE, Hotamisligil GS 2003 Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112:1785-1788
34. Booth AD, Wallace S, McEniery CM, Yasmin, Brown J, Jayne DR, Wilkinson IB 2004 Inflammation and arterial stiffness in systemic vasculitis: a model of vascular inflammation Arthritis Rheum 50:581-588
35. Klocke R, Cockcroft JR, Taylor GJ, Hall IR, Blake DR 2003 Arterial stiffness and central blood pressure, as determined by pulse wave analysis, in rheumatoid arthritis. Ann Rheum Dis 62:414-418
36. Selzer F, Sutton-Tyrrell K, Fitzgerald S, Tracy R, Kuller L, Manzi S 2001 Vascular stiffness in women with systemic lupus erythematosus. Hypertension 37:1075-1082
37. Wong M, Toh L, Wilson A, Rowley K, Karschimkus C, Prior D, Romas E, Clemens L, Dragicevic G, Harianto H, Wocks I, McColl G, Best J, Jenkins A 2003 Reduced arterial elasticity in rheumatoid arthritis and the relationship to vascular disease risk factors and inflammation. Arthritis Rheum 48:81-89
38. Van Doornum S, McColl G, Jenkins A, Green DJ, Wicks IP 2003 Screening for atherosclerosis in patients with rheumatoid arthritis: comparison of two in vivo tests of vascular function. Arthritis Rheum 48:72-80
39. Yasmin, McEniery CM, Wallace S, Mackenzie IS, Cockcroft JR, Wilkinson IB 2004 C-Reactive protein is associated with arterial stiffness in apparently healthy individuals. Arterioscler Thromb Vasc Biol 24:969-974
40. Pirro M, Schillaci G, Savarese G, Gemelli F, Vaudo G, Siepi D, Bagaglia F, Mannarino E 2004 Low-grade systemic inflammation impairs arterial stiffness in newly diagnosed hypercholesterolaemia. Eur J Clin Invest 34:335-341
41. Heinrich PC, Castell JV, Andus T 1990 Interleukin-6 and the acute phase response. Biochem J 265:621-636
42. Henry RMA, Kostense PJ, Spijkerman AMW, Dekker JM, Nijpels G, Heine RJ, Kamp O, Westerhof N, Bouter LM, Stehouwer CDA 2003 Arterial stiffness increases with deteriorating glucose tolerance status: The Hoorn Study. Circulation 107:2089-2095