Neoadjuvant chemoradiotherapy for rectal carcinoma: Effects on anastomotic leak rate and postoperative bladder dysfunction after non-emergency sphincter-preserving anterior rectal resection: Results of the quality assurance in rectal cancer surgery multicenter observational trial

Langenbeck's Archives of Surgery

Volumn 395, Issue 8, 2010, Pages 1031-1038

  Garlipp, Benjamin ^a,b   Ptok, Henry ^a,c   Schmidt, Uwe ^a,d   Meyer, Frank ^a,b   Gastinger, Ingo ^a   Lippert, Hans ^a,b  

^a An Institut für Qualitätssicherung in der Operativen Medizin   (Germany)

^b UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^c CARL THIEM KLINIKUM   (Germany)

^d StatConsult GmbH   (Germany)

Author keywords

Anastomotic leakage; Bladder dysfunction; Preoperative chemoradiotherapy; Rectal cancer; Short term postoperative outcome

Indexed keywords

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; AGED; ANAL CANAL; ANASTOMOSIS LEAKAGE; ARTICLE; BLADDER DISEASE; CANCER STAGING; CLINICAL TRIAL; COMPARATIVE STUDY; FEMALE; HEALTH CARE QUALITY; HUMAN; MALE; MIDDLE AGED; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; MULTIVARIATE ANALYSIS; PATHOLOGY; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; RECTUM; RECTUM TUMOR; RETROSPECTIVE STUDY; RISK FACTOR;

AGED; AGED, 80 AND OVER; ANAL CANAL; ANASTOMOTIC LEAK; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOADJUVANT THERAPY; NEOPLASM STAGING; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; QUALITY ASSURANCE, HEALTH CARE; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; RECTUM; RETROSPECTIVE STUDIES; RISK FACTORS; URINARY BLADDER DISEASES;

EID: 79952844102     PISSN: 14352443     EISSN: 14352451     Source Type: Journal    
DOI: 10.1007/s00423-010-0708-0     Document Type: Article

References (39)

1. Stockholm Rectal Cancer Study Group (1990) Preoperative short-term radiation therapy in operable rectal carcinoma. A prospective randomized trial. Cancer 66:49-55
2. Stockholm Colorectal Cancer Study Group (1996) Randomized study on preoperative radiotherapy in rectal carcinoma. Ann Surg Oncol 3:423-430
3. Swedish Rectal Cancer Trial (1996) Local recurrence rate in a randomised multicentre trial of preoperative radiotherapy compared with operation alone in resectable rectal carcinoma. Eur J Surg 162:397-402
4. Colorectal cancer collaborative group (2001) Adjuvant radiotherapy for rectal cancer: a systematic overview of 8, 507 patients from 22 randomised trials. Lancet 358:1291-1304
5. Cammà C, Giunta M, Fiorica F, Pagliaro L, Craxì A, Cottone M (2000) Preoperative radiotherapy for resectable rectal cancer: a meta-analysis. JAMA 284:1008-1015 (Pubitemid 30659131)
6. Kapiteijn E, Marijnen CA, Nagtegaal ID, Putter H, Steup WH, Wiggers T, Rutten HJ, Pahlman L, Glimelius B, van Krieken JH, Leer JW, van de Velde CJ (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345:638-646
7. Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens J, Liersch T, Schmidberger H, Raab R (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731-1740
8. Schmiegel W, Reinacher-Schick A, Arnold D, Graeven U, Heinemann V, Porschen R, Riemann J, Rödel C, Sauer R, Wieser M, Schmitt W, Schmoll H, Seufferlein T, Kopp I, Pox C (2008) Update S3-guideline " colorectal cancer" 2008. Z Gastroenterol 46:799-840
9. Ulrich A, Schwerdt J, Z'graggen K, Kienle P, Weitz J, Büchler MW (2007) Acceptance of neoadjuvant short-term radiotherapy: a survey under surgeons and radiotherapists. Langenbecks Arch Surg 392:525-533 (Pubitemid 47246704)
10. Junginger T, Hermanek P, Oberholzer K, Schmidberger H (2006) Rectal carcinoma: is too much neoadjuvant therapy performed? Proposals for a more selective MRI based indication. Zentralbl Chir 131:275-284 (Pubitemid 44407069)
11. Ulrich A, Weitz J, Büchler MW (2009) Rectal cancer. How much radiotherapy do surgery patients need? Chirurg 80:266-273
12. Birgisson H, Påhlman L, Gunnarsson U, Glimelius B (2005) Occurrence of second cancers in patients treated with radiotherapy for rectal cancer. J Clin Oncol 23:6126-6131
13. Pollack J, Holm T, Cedermark B, Altman D, Holmström B, Glimelius B, Mellgren A (2006) Late adverse effects of short-course preoperative radiotherapy in rectal cancer. Br J Surg 93:1519-1525 (Pubitemid 44893654)
14. Marijnen CA, Nagtegaal ID, Kapiteijn E, Kranenbarg EK, Nordijk EM, van Krieken JH, van de Velde CJ, Leer JW, Cooperative investigators of the Dutch Colorectal Cancer Group (2003) Radiotherapy does not compensate for positive resection margins in rectal cancer patients: report of a multicenter randomized trial. Int J Radiat Oncol Biol Phys 55:1311-1320 (Pubitemid 36338299)
15. Peeters KCMJ, van de Velde CJH, Leer JWH, Martijn H, Junggeburt JMC, Kranenbarg EK, Steup WH, Wiggers T, Rutten HJ, Marijnen CAM (2005) Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients - a Dutch colorectal cancer group study. J Clin Oncol 23:6199-6206
16. Marijnen CAM, Kapiteijn E, van de Velde CJH, Martijn H, Steup WH, Wiggers T, Kranenbarg EK, Leer JWH (2002) Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 20:817-825 (Pubitemid 34111391)
17. Akiyoshi T, Kuroyanagi H, Oya M, Konishi T, Fukuda M, Fujimoto Y, Ueno M, Yamaguchi T, Muto T (2009) Safety of laparoscopic total mesorectal excision for low rectal cancer with preoperative chemoradiation therapy. J Gastrointest Surg 13:521-525
18. Horisberger K, Hofheinz RD, Palma P, Volkert AK, Rothenhoefer S, Wenz F, Hochhaus A, Post S, Willeke F (2008) Tumor response to neoadjuvant chemoradiation in rectal cancer: predictor for surgical morbidity? Int J Colorectal Dis 23:257-264
19. Rosati R, Bona S, Romario UF, Elmore U, Furlan N (2007) Laparoscopic total mesorectal excision after neoadjuvant chemoradiotherapy. Surg Oncol 16(Suppl 1):S83-S89
20. Lyall A, Mc Adam TK, Townend J, Loudon MA (2007) Factors affecting anastomotic complications following anterior resection in rectal cancer. Colorectal Dis 9:801-807 (Pubitemid 47578026)
21. Valenti V, Hernandez-Lizoain JL, Baixauli J, Pastor C, Aristu J, Diaz-Gonzalez J, Beunza JJ, Alvarez-Cienfuegos JA (2007) Analysis of early postoperative morbidity among patients with rectal cancer treated with and without neoadjuvant chemoradiotherapy. Ann Surg Oncol 14:1744-1751 (Pubitemid 46791013)
22. Buie WD, MacLean AR, Attard JP, Brasher PMA, Chan AK (2005) Neoadjuvant chemoradiation increases the risk of pelvic sepsis after radical excision of rectal cancer. Dis Colon Rectum 48:1868-1874 (Pubitemid 41437670)
23. Turner II, Russell GB, Blackstock AW, Levine EA (2004) Impact of neoadjuvant therapy on postoperative complications in patients undergoing resection for rectal adenocarcinoma. Am Surg 70:1045-1049
24. Valero G, Luján JA, Hernández Q, De Las Heras M, Pellicer E, Serrano A, Parrilla P (2003) Neoadjuvant radiation and chemotherapy in rectal cancer does not increase postoperative complications. Int J Colorectal Dis 18:495-499 (Pubitemid 37265861)
25. Martel G, Al-Suhaibani Y, Moloo H, Haggar F, Friedlich M, Mamazza J, Poulin EC, Stern H, Boushey RP (2008) Neoadjuvant therapy and anastomotic leak after tumor-specific mesorectal excision for rectal cancer. Dis Colon Rectum 51:1195-1201
26. Ulrich A, Weitz J, Slodczyk M, Koch M, Jaeger D, Münter M, Büchler MW (2009) Neoadjuvant treatment does not influence perioperative outcome in rectal cancer surgery. Int J Radiat Oncol Biol Phys 75:129-136
27. Urso E, Serpentini S, Pucciarelli S, de Salvo GL, Friso ML, Fabris G, Lonardi S, Ferraro B, Bruttocao A, Aschele C, Nitti D (2006) Complications, functional outcome and quality of life after intensive preoperative chemoradiotherapy for rectal cancer. Eur J Surg Oncol 32:1201-1208 (Pubitemid 44793676)
28. Stumpf M, Junge K, Wendlandt M, Krones C, Ulmer F, Klinge U, Schumpelick V (2009) Risk factors for anastomotic leakage after colorectal surgery. Zentralbl Chir 134:242-248
29. Junginger T, Kneist W, Sultanov F, Heintz A (2003) Indicators of quality in surgical treatment of rectal carcinoma. Chirurg 74:444-450, discussion 450-1
30. Junginger T, Kneist W, Heintz A (2003) Influence of identification and preservation of pelvic autonomic nerves in rectal cancer surgery on bladder dysfunction after total mesorectal excision. Dis Colon Rectum 46:621-628 (Pubitemid 36576419)
31. Maurer CA, Z'Graggen K, Renzulli P, Schilling MK, Netzer P, Büchler MW (2001) Total mesorectal excision preserves male genital function compared with conventional rectal cancer surgery. Br J Surg 88:1501-1505
32. Bonnel C, Parc YR, Pocard M, Dehni N, Caplin S, Parc R, Tiret E (2002) Effects of preoperative radiotherapy for primary resectable rectal adenocarcinoma on male sexual and urinary function. Dis Colon Rectum 45:934-939 (Pubitemid 34761474)
33. Heriot AG, Tekkis PP, Fazio VW, Neary P, Lavery IC (2005) Adjuvant radiotherapy is associated with increased sexual dysfunction in male patients undergoing resection for rectal cancer: a predictive model. Ann Surg 242:502-510, discussion 510-511
34. Trojano M, Pellegrini F, Paolicelli D, Fuiani A, Di Renzo V (2009) observational studies: propensity score analysis of non-randomized data. Int MS J 16:90-97
35. Matthiessen P, Hallböök O, Andersson M, Rutegård J, Sjödahl R (2004) Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis 6:462-469 (Pubitemid 39534318)
36. Holm T, Singnomklao T, Rutqvist LE, Cedermark B (1996) Adjuvant preoperative radiotherapy in patients with rectal carcinoma. Adverse effects during long term follow-up of two randomized trials. Cancer 78:968-976 (Pubitemid 26284860)
37. Glimelius B, Grönberg H, Järhult J, Wallgren A, Cavallin-Ståhl E (2003) A systematic overview of radiation therapy effects in rectal cancer. Acta Oncol 42:476-492 (Pubitemid 37193839)
38. Krones CJ, Stumpf M, Schumpelick V (2009) Surgery for rectal cancer. Chirurg 80:303-310
39. Strassburg J, Lewin A, Ludwig K, Kilian L, Linke J, Loy V, Knuth P, Püttcher O, Ruehl U, Stöckmann F, Hackenthal M, Hopfenmüller W, Huppertz A (2007) Optimised surgery (so-called TME surgery) and high-resolution MRI in the planning of treatment of rectal carcinoma. Langenbecks Arch Surg 392:179-188 (Pubitemid 46328686)