Tumor response to neoadjuvant chemoradiation in rectal cancer: Predictor for surgical morbidity?

International Journal of Colorectal Disease

Volumn 23, Issue 3, 2008, Pages 257-264

  Horisberger, K ^a   Hofheinz, R D ^a   Palma, P ^a   Volkert, A K ^a   Rothenhoefer, S ^a   Wenz, F ^a   Hochhaus, A ^a   Post, S ^a   Willeke, F ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Marienkrankenhaus Siegen ^*  (Germany)

Author keywords

Complications; Neoadjuvant chemoradiation; Rectal cancer; Response

Indexed keywords

ANTINEOPLASTIC AGENT; CAPECITABINE; CETUXIMAB; IRINOTECAN;

ADJUVANT THERAPY; ADULT; AGED; ANASTOMOSIS LEAKAGE; ANUS SPHINCTER; ARTICLE; BLADDER DYSFUNCTION; CANCER ADJUVANT THERAPY; CANCER GRADING; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER STAGING; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEART INFARCTION; HISTOPATHOLOGY; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; MINIMAL RESIDUAL DISEASE; NEUROGENIC BLADDER; PARALYTIC ILEUS; PELVIS ABSCESS; PERIOPERATIVE PERIOD; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PNEUMONIA; PREOPERATIVE CARE; PRIORITY JOURNAL; RECTUM ANASTOMOSIS; RECTUM CARCINOMA; RECTUM FISTULA; RECTUM HEMORRHAGE; RECTUM SURGERY; SEPSIS; SURGICAL MORTALITY; SURGICAL TECHNIQUE; SUTURING METHOD; TREATMENT RESPONSE; WOUND COMPLICATION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; COLECTOMY; FEMALE; FOLLOW-UP STUDIES; GERMANY; HUMANS; MALE; MIDDLE AGED; MORBIDITY; NEOADJUVANT THERAPY; NEOPLASM STAGING; POSTOPERATIVE COMPLICATIONS; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; TIME FACTORS; TREATMENT OUTCOME;

EID: 38649121717     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-007-0408-6     Document Type: Article

References (49)

1. Enker WE, Thaler HT, Cranor ML, Polyak T (1995) Total mesorectal excision in the operative treatment of carcinoma of the rectum. J Am Coll Surg 181:335-346
2. MacFarlane JK, Ryall RD, Heald RJ (1993) Mesorectal excision for rectal cancer. Lancet 341:457-60
3. Law WL, Chu KW (2004) Anterior resection for rectal cancer with mesorectal excision: A prospective evaluation of 622 patients. Ann Surg 240:260-8
4. Heald RJ, Smedh RK, Kald A, Sexton R, Moran BJ (1997) Abdominoperineal excision of the rectum-an endangered operation. Dis Colon Rectum 40:747-51
5. Carlsen E, Schlichting E, Guldvog I, Johnson E, Heald RJ (1998) Effect of the introduction of total mesorectal excision for the treatment of rectal cancer. Br J Surg 85:526-529
6. Karanija ND, Corder AP, Bearn P, Heald RJ (1994) Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg 81:1224-1226
7. Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R (2004) Preoperative versus postoperative chemoradiotherapy in rectal cancer. for the German rectal Cancer Study Group N Engl J Med 351:1731-1740
8. Rödel C, Martus H, Papadoupolos T, Füzesi L, Klimpfinger M, Fietkau R, Liersch T, Hohenberger W, Raab R, Sauer R, Wittekind C (2005) Prognostic significance of tumor regression after preoperative chemoradiotherapy in rectal cancer. J Clin Oncol 23:8688-8696
9. Janjan NA, Khoo VS, Rich TA, Evetts PA, Goswitz MS, Allen PK, Skibber JM (1998) Locally advanced rectal cancer: Surgical complications after infusional chemotherapy and radiation therapy. Radiology 206:131-136
10. Crane CH, Skibber J (2003) Preoperative chemoradiation for locally advanced rectal cancer: Rationale, technique, and results of treatment. Int J Radiat Oncol Biol Phys 21:265-270
11. Bujko K, Nowacki MP, Nesierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M (2006) Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. for the Polish Colorectal Study Group Br J Surg 93:1215-1223
12. Wong RK, Tandan V, De Silva S, Figueredo A (2007) Pre-operative radiotherapy and curative surgery for the management of localized rectal carcinoma. Cochrane Database Syst Rev 2:CD002102 (online)
13. Marijnen CAM, Kapiteijn E, van de Velde CJH, Martijn H, Steup WH, Wiggers T, Klein Kranenbarg E, Leer JWH (2002) Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: Report of a Multicenter randomized trial. the Cooperative Investigators of the Dutch Colorectal Cancer Group J Clin Oncol 20:817-825
14. Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C, Chau I, Van Cutsem E (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337-345
15. Hofheinz RD, v. Gerstenbergk-Helldorff B, Wenz F, Gnad U, Kraus-Tiefenbacher U, Müldner A, Hehlmann R, Post S, Hochhaus A, Willeke F (2005) Phase I trial of capecitabine and weekly irinotecan in combination with radiotherapy for neoadjuvant therapy of rectal cancer. J Clin Oncol 23:1350-1357
16. Willeke F, Horisberger K, Kraus-Tiefenbacher U, Wenz F, Leitner A, Hochhaus A, Grobholz R, Willer A, Kähler G, Post S, Hofheinz R (2007) A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer. Br J Cancer 96:912-917
17. Hofheinz R, Horisberger K, Woernle C, Wenz F, Kraus-Tiefenbacher U, Kähler G, Dinter D, Grobholz R, Heeger S, Post S, Hochhaus A, Willeke F (2007) Phase I trial of Cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer. Int J Radiat Oncol Biol Phys 66:1384-1390
18. Z'Graggen K, Maurer CA, Birrer S, Giachino D, Kern B, Buchler MW (2001) A new surgical concept for rectal replacement after low anterior resection: The transverse coloplasty pouch. Ann Surg 234:780-785
19. UICC (2002) TNM classification of malignant tumours, 6th edn. Sobin LH, Wittekind C (eds) Wiley-Liss, New York
20. Japanese Society for Cancer of the Colon and Rectum (JSCCR) (1997) Japanese classification of colorectal carcinoma, 1st English edn. Kanehara & Co, Tokyo
21. Peel ALG, Taylor EW (1991) Proposed definitions for the audit of postoperative infection: A discussion paper. Ann Royal Coll Surg Engl 73:385-388
22. Alves A, Panis Y, Mathieu P, Kwiatkowski F, Slim K, Mantion G (2005) Mortality and morbidity after surgery of mid and low rectal cancer. Gastroenterol Clin Biol. the Association Francaise de Chirurgie 29:509-514
23. Valero G, Lujan JA, Hernandez Q, de las Heras M, Pellicer E, Serrano A, Parrilla P (2003) Neoadjuvant radiation and chemotherapy in rectal cancer does not increase postoperative complications. Int J Colorectal Dis 18:495-499
24. Hilsabeck JR (1982) The presacral space as a collector of fluid accumulations following rectal anastomosis: Tolerance of rectal anastomosis to closed suction pelvic drainage. Dis Colon Rectum 25:680-684
25. Hyams DM, Mamounas EP, Petrelli N, Rockette H, Jones J, Wieand S, Deutsch M, Wickerham L, Fisher B, Wolmark N (1997) A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum. Dis Colon Rectum 40:131-139
26. Luna-Perez P, Rodriguez-Ramirez S, Hernandez-Pacheco F, Gutierrez de la Barrera M, Fernandez R, Labastida S (2003) Anal sphincter preservation on locally advanced low rectal adenocarcinoma after preoperative chemoradiation therapy and coloanal anastomosis. J Surg Oncol 82:3-9
27. Chao M, Gibbs P, Tjandra J, Cullinan M, McLaughlin S, Faragher I, Skinners I, Jones I (2005) Preoperative chemotherapy and radiotherapy for locally advanced rectal cancer. ANZ J Surg 75:286-291
28. Mohiuddin M, Winter K, Mitchel E, Nader H, Yuen A, Nichols C Shane R, Hayostek C, Willet C (2006) Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation therapy oncology group trial 0012. J Clin Oncol 24:650-655
29. Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M (1998) Risk factors for anastomotic leakage after resection of rectal cancer. Br J Surg 85:355-358
30. Matthiessen P, Hallböök O, Andersson M, Rutegard J, Sjödahl R (2004) Risk factors for anastomotic leakage after anterior resection of the rectum. Colorect Dis 6:462-469
31. Gerard JP, Chapet O, Nemoz C, Romestaing P, Mornex F, Coquard R, Barbet N, Atlan D, Adeleine P, Freyer G (2003) Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and Oxaliplatin-containing regimen: The Lyon R0-04 phase II trial. J Clin Oncol 21:1119-1124
32. Pucciarelli S, Toppan P, Friso ML, Fornasiero A, Vieceli G, Marchiori E, Lise M (1999) Preoperative combined radiotherapy and chemotherapy for rectal cancer does not affect early postoperative morbidity and mortality in low anterior resection. Dis Colon Rectum 42:1276-1284
33. Mehta VK, Poen J, Ford J, Edelstein PS, Vierra M, Bastidas AJ, Young H, Fisher G (2001) Radiotherapy, concomitant protracted-venous-infusion 5-fluorouracil, and surgery for ultrasound-staged T3 or T4 rectal cancer. Dis Colon Rectum 44:52-58
34. Klautke G, Feyerherd P, Ludwig K, Prall F, Foitzik T, Fietkau R (2005) Intensified concurrent chemoradiotherapy with 5-fluorouracil and irinotecan as neoadjuvant treatment in patients with locally advanced rectal cancer. Br J Cancer 92:1215-20
35. Johnson LB, Jorgensen LN, Adawi D, Blomqvist P, Asklöf GB, Gottrup F, Jeppsson B (2005) The effect of preoperative radiotherapy on systemic collagen disposition and postoperative infective complications in rectal cancer patients. Dis Colon Rectum 48:1573-1580
36. Tran CL, Udani S, Holt A, Arnell T, Kumar R, Stamos MJ (2006) Evaluation of safety of increased time interval between chemoradiation and resection of rectal cancer. Am J Surg 192: 873-877
37. Moore HG, Gittleman AE, Minsky BD, Wong D, Paty PB, Weiser M, Temple L, Saltz L, Shia J, Guillem JG (2004) Rate of pathologic complete response with increased interval between preoperative combined modality therapy and rectal cancer resection. Dis Colon Rectum 47:279-286
38. Kundel Y, Brenner B, Symon Z, Oberman B, Sadezki S, Koller M, Catane R, Pfeffer R (2007) A phase II study of oral UFT and leucovorin concurrently with pelvic irradiation as neoadjuvant chemoradiation for rectal cancer. Anticancer Res 27:2877-80
39. Lay GC, Caraul B, Dessi M, Orru S, Murtas R, Derrida MA, Fariqu R, Farci D, Maxia L, Casula G, Amichetti M (2007) Phase II study of preoperative irradiation and chemotherapy with capecitabine in patients with locally advanced rectal carcinoma. J Exp Clin Cancer Res 26:61-70
40. Machiels JP, Sempoux C, Scalliet P, Coche JC, Humblet Y, Van Cutsem E, Kerger J, Canon JL, Peeters M, Aydin S, Laurent S, Kartheuser A, Coster B, Roels S, Daisne JF, Honhon B, Duck L, Kirkove C, Bonny MA, Haustermans K (2007) Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer. Ann Oncol 18:738-744
41. Hospers GA, Punt CJ, Tesselaar ME, Cats A, Havenga K, Leer JW, Marijnen CA, Jansen EP, Van Krieken HH, Wiggers T, Van de Velde CJ, Mulder NH (2007) Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal cancer. A phase I-II multicenter study of the Dutch Colorectal Cancer Group. Ann Surg Oncol 14:2773-2779
42. Engelen SM, Beets GL, Beets-Tan RG (2007) Role of preoperative local and distant staging in rectal cancer. Onkologie 30:141-145
43. Stein DE, Mahmoud NN, Anne PR, Rose DG, Isenberg GA, Goldstein SD, Mitchell E, Fry RD (2003) Longer time interval between completion of neoadjuvant chemoradiation and surgical resection does not improve downstaging of rectal carcinoma. Dis Colon Rectum 46:448-453
44. Swedish Rectal Cancer Trial (1997) Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 336:980-987
45. Kapiteijn E, Marijnen CAM, Nagtegaal ID, Putter H, Steup WH, Wiggers T, Rutten HJT, Pahlman L, Glimelius B, van Krieken HJM, Leer JWH, van de Velde CJH (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. for the Dutch Colorectal Cancer Group N Engl J Med 345:638-646
46. Peeters KCMJ, van de Velde CJH, Leer JWH, Martijn H, Junggeburt JMC, Klein Kranenbarg E, Steup WH, Wiggers T, Rutten HJ, Martijnen CAM (2005) Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: Increased bowel dysfunction in irradiated patients-a Dutch colorectal cancer group study. J Clin Oncol 23:6199-6206
47. Birgisson H, Pahlman L, Gunnarsson U, Glimelius B (2005) Adverse effects of preoperative radiation therapy for rectal cancer: Long-term follow-up of the Swedish Rectal Cancer Trial. Swedish Rectal Cancer Trial Group. J Clin Oncol 23:8697-8705
48. Tsujinaka S, Kawamura YJ, Konishi F, Aihara H, Maeda T, Mizokami K (2008) Long-term efficacy of preoperative radiotherapy for locally advanced rectal cancer. Int J Colorectal Dis 23:67-76
49. Bell SW, Walker KG, Rickard MJFX, Sinclair G, Dent OF, Chapuis PH, Bokey EL (2003) Anastomotic leakage after curative anterior resection results in a higher prevalence of local recurrence. Br J Surg 90:1261-1266