Scale-up synthesis of a TRPV1 antagonist featuring a facile thiazolo[5,4-d]pyrimidine formation

Organic Process Research and Development

Volumn 15, Issue 2, 2011, Pages 382-388

  Liu, Jing ^a   Fitzgerald, Anne E ^a   Lebsack, Alec D ^a   Mani, Neelakandha S ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRIMIDINES; LARGE SCALE PREPARATION; PYRIMIDINE RING; SCALE-UP; SYNTHESIS FEATURES;

AROMATIC COMPOUNDS;

EID: 79952831874     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op1002984     Document Type: Article

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27. The isolated product was found to contain ∼0.5 equiv of HCl based on elemental analysis. See Experimental Section for details.