-
1
-
-
0025370870
-
T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
-
Ota K, Matsui M, Milford EL, Mackin GL, Weiner HL, et al. (1990) T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346: 183-187.
-
(1990)
Nature
, vol.346
, pp. 183-187
-
-
Ota, K.1
Matsui, M.2
Milford, E.L.3
Mackin, G.L.4
Weiner, H.L.5
-
2
-
-
0024478231
-
Evidence that Mls-2 antigens which delete V beta 3+ T cells are controlled by multiple genes
-
Pullen AM, Marrack P, Kappler JW, (1989) Evidence that Mls-2 antigens which delete V beta 3+ T cells are controlled by multiple genes. J Immunol 142: 3033-3037.
-
(1989)
J Immunol
, vol.142
, pp. 3033-3037
-
-
Pullen, A.M.1
Marrack, P.2
Kappler, J.W.3
-
3
-
-
78649897032
-
Human regulatory T cells in autoimmune diseases
-
doi:10.1016
-
Cvetanovich GL, Hafler DA, (2010) Human regulatory T cells in autoimmune diseases. Curr Opin Immunol doi:10.1016.
-
(2010)
Curr Opin Immunol
-
-
Cvetanovich, G.L.1
Hafler, D.A.2
-
4
-
-
43949105866
-
Regulatory T cells and immune tolerance
-
Sakaguchi S, Yamaguchi T, Nomura T, Ono M, (2008) Regulatory T cells and immune tolerance. Cell 133: 775-787.
-
(2008)
Cell
, vol.133
, pp. 775-787
-
-
Sakaguchi, S.1
Yamaguchi, T.2
Nomura, T.3
Ono, M.4
-
5
-
-
1842732224
-
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
-
Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA, (2004) Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 199: 971-979.
-
(2004)
J Exp Med
, vol.199
, pp. 971-979
-
-
Viglietta, V.1
Baecher-Allan, C.2
Weiner, H.L.3
Hafler, D.A.4
-
6
-
-
27944499757
-
Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
-
Haas J, Hug A, Viehöver A, Fritzsching B, Falk CS, et al. (2005) Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol 35: 3343-3352.
-
(2005)
Eur J Immunol
, vol.35
, pp. 3343-3352
-
-
Haas, J.1
Hug, A.2
Viehöver, A.3
Fritzsching, B.4
Falk, C.S.5
-
7
-
-
37149003363
-
Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level
-
Venken K, Hellings N, Thewissen M, Somers V, Hensen K, et al. (2008) Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level. Immunology 123: 79-89.
-
(2008)
Immunology
, vol.123
, pp. 79-89
-
-
Venken, K.1
Hellings, N.2
Thewissen, M.3
Somers, V.4
Hensen, K.5
-
8
-
-
34548721641
-
Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis
-
Haas J, Fritzsching B, Trübswetter P, Korporal M, Milkova L, et al. (2007) Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J Immunol 179: 1322-1330.
-
(2007)
J Immunol
, vol.179
, pp. 1322-1330
-
-
Haas, J.1
Fritzsching, B.2
Trübswetter, P.3
Korporal, M.4
Milkova, L.5
-
9
-
-
44449171488
-
Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression
-
Venken K, Hellings N, Broekmans T, Hensen K, Rummens JL, et al. (2008) Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J Immunol 180: 6411-6420.
-
(2008)
J Immunol
, vol.180
, pp. 6411-6420
-
-
Venken, K.1
Hellings, N.2
Broekmans, T.3
Hensen, K.4
Rummens, J.L.5
-
10
-
-
0032495663
-
Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis
-
Pender MP, (1998) Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis. Lancet 351: 978-981.
-
(1998)
Lancet
, vol.351
, pp. 978-981
-
-
Pender, M.P.1
-
11
-
-
0034633768
-
Defective T cell fas function in patients with multiple sclerosis
-
Comi C, Leone M, Bonissoni S, DeFranco S, Bottarel F, et al. (2000) Defective T cell fas function in patients with multiple sclerosis. Neurology 55: 921-927.
-
(2000)
Neurology
, vol.55
, pp. 921-927
-
-
Comi, C.1
Leone, M.2
Bonissoni, S.3
DeFranco, S.4
Bottarel, F.5
-
12
-
-
0033525162
-
Impaired apoptosis in mitogen-stimulated lymphocytes of patients with multiple sclerosis
-
Macchi B, Matteucci C, Nocentini U, Caltagirone C, Mastino A, (1999) Impaired apoptosis in mitogen-stimulated lymphocytes of patients with multiple sclerosis. Neuroreport 10: 399-402.
-
(1999)
Neuroreport
, vol.10
, pp. 399-402
-
-
Macchi, B.1
Matteucci, C.2
Nocentini, U.3
Caltagirone, C.4
Mastino, A.5
-
13
-
-
0034703181
-
Impaired fas-independent apoptosis of T lymphocytes in patients with multiple sclerosis
-
Sharief MK, (2000) Impaired fas-independent apoptosis of T lymphocytes in patients with multiple sclerosis. J Neuroimmunol 109: 236-243.
-
(2000)
J Neuroimmunol
, vol.109
, pp. 236-243
-
-
Sharief, M.K.1
-
14
-
-
21244465055
-
In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death
-
Fritzsching B, Oberle N, Eberhardt N, Quick S, Haas J, et al. (2005) In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death. J Immunol 175: 32-36.
-
(2005)
J Immunol
, vol.175
, pp. 32-36
-
-
Fritzsching, B.1
Oberle, N.2
Eberhardt, N.3
Quick, S.4
Haas, J.5
-
15
-
-
33751227462
-
Similar sensitivity of regulatory T cells towards CD95L-mediated apoptosis in patients with multiple sclerosis and healthy individuals
-
Fritzsching B, Korporal M, Haas J, Krammer PH, Suri-Payer E, et al. (2006) Similar sensitivity of regulatory T cells towards CD95L-mediated apoptosis in patients with multiple sclerosis and healthy individuals. J Neurol Sci 251: 91-97.
-
(2006)
J Neurol Sci
, vol.251
, pp. 91-97
-
-
Fritzsching, B.1
Korporal, M.2
Haas, J.3
Krammer, P.H.4
Suri-Payer, E.5
-
16
-
-
33748296240
-
Human CD4+CD25hiFoxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
-
Vukmanovic-Stejic M, Zhang Y, Cook JE, Fletcher JM, McQuaid A, et al. Human CD4+CD25hiFoxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest 116: 2423-2433.
-
J Clin Invest
, vol.116
, pp. 2423-2433
-
-
Vukmanovic-Stejic, M.1
Zhang, Y.2
Cook, J.E.3
Fletcher, J.M.4
McQuaid, A.5
-
17
-
-
33751175422
-
Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death
-
Fritzsching B, Oberle N, Pauly E, Geffers R, Buer J, et al. (2006) Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death. Blood 108: 3371-3378.
-
(2006)
Blood
, vol.108
, pp. 3371-3378
-
-
Fritzsching, B.1
Oberle, N.2
Pauly, E.3
Geffers, R.4
Buer, J.5
-
18
-
-
70449497739
-
Regulatory T cells and inhibitory cytokines in autoimmunity
-
Bettini M, Vignali DA, (2009) Regulatory T cells and inhibitory cytokines in autoimmunity. Curr Opin Immunol 21: 612-618.
-
(2009)
Curr Opin Immunol
, vol.21
, pp. 612-618
-
-
Bettini, M.1
Vignali, D.A.2
-
19
-
-
38749143286
-
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
-
Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, et al. (2008) Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 172: 146-155.
-
(2008)
Am J Pathol
, vol.172
, pp. 146-155
-
-
Tzartos, J.S.1
Friese, M.A.2
Craner, M.J.3
Palace, J.4
Newcombe, J.5
-
20
-
-
33646593910
-
Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sézary syndrome from other cutaneous T-cell lymphomas
-
Klemke CD, Fritzsching B, Franz B, Kleinmann EV, Oberle N, et al. (2006) Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sézary syndrome from other cutaneous T-cell lymphomas. Leukemia 20: 1123-1129.
-
(2006)
Leukemia
, vol.20
, pp. 1123-1129
-
-
Klemke, C.D.1
Fritzsching, B.2
Franz, B.3
Kleinmann, E.V.4
Oberle, N.5
-
21
-
-
34447500365
-
Low number of regulatory T cells in skin lesions of patients with cutaneous lupus erythematosus
-
Franz B, Fritzsching B, Riehl A, Oberle N, Klemke CD, et al. (2007) Low number of regulatory T cells in skin lesions of patients with cutaneous lupus erythematosus. Arthritis Rheum 56: 1910-1920.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 1910-1920
-
-
Franz, B.1
Fritzsching, B.2
Riehl, A.3
Oberle, N.4
Klemke, C.D.5
-
22
-
-
0342906187
-
Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
-
Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, et al. (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47: 707-717.
-
(2000)
Ann Neurol
, vol.47
, pp. 707-717
-
-
Lucchinetti, C.1
Brück, W.2
Parisi, J.3
Scheithauer, B.4
Rodriguez, M.5
-
23
-
-
33846817153
-
Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
-
Feger U, Luther C, Poeschel S, Melms A, Tolosa E, et al. (2007) Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients. Clin Exp Immunol 147: 412-418.
-
(2007)
Clin Exp Immunol
, vol.147
, pp. 412-418
-
-
Feger, U.1
Luther, C.2
Poeschel, S.3
Melms, A.4
Tolosa, E.5
-
24
-
-
33745817085
-
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
-
Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203: 1701-1711.
-
(2006)
J Exp Med
, vol.203
, pp. 1701-1711
-
-
Liu, W.1
Putnam, A.L.2
Xu-Yu, Z.3
Szot, G.L.4
Lee, M.R.5
-
25
-
-
77954721060
-
Regulatory T cells in tumor immunity
-
Nishikawa H, Sakaguchi S, (2010) Regulatory T cells in tumor immunity. Int J Cancer 127: 759-767.
-
(2010)
Int J Cancer
, vol.127
, pp. 759-767
-
-
Nishikawa, H.1
Sakaguchi, S.2
-
26
-
-
38349154611
-
Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis
-
Haas J, Schopp L, Storch-Hagenlocher B, Fritzsching B, Jacobi C, et al. (2008) Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis. Blood 111: 761-766.
-
(2008)
Blood
, vol.111
, pp. 761-766
-
-
Haas, J.1
Schopp, L.2
Storch-Hagenlocher, B.3
Fritzsching, B.4
Jacobi, C.5
-
27
-
-
70149099765
-
Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis
-
Huang YH, Zozulya AL, Weidenfeller C, Metz I, Buck D, et al. (2009) Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis. Ann Neurol 66: 171-183.
-
(2009)
Ann Neurol
, vol.66
, pp. 171-183
-
-
Huang, Y.H.1
Zozulya, A.L.2
Weidenfeller, C.3
Metz, I.4
Buck, D.5
-
28
-
-
53749105749
-
Effects of natalizumab treatment on Foxp3+ regulatory cells
-
Stenner MP, Waschbisch A, Buck D, Doerck S, Einsele H, et al. (2008) Effects of natalizumab treatment on Foxp3+ regulatory cells. PLoS One 3: e3319.
-
(2008)
PLoS One
, vol.3
-
-
Stenner, M.P.1
Waschbisch, A.2
Buck, D.3
Doerck, S.4
Einsele, H.5
-
29
-
-
0020406015
-
In-situ characterization of mononuclear cell infiltrates in lesions of multiple sclerosis
-
Nyland H, Mork S, Matre R, (1982) In-situ characterization of mononuclear cell infiltrates in lesions of multiple sclerosis. Neuropathol Appl Neurobiol 8: 403-411.
-
(1982)
Neuropathol Appl Neurobiol
, vol.8
, pp. 403-411
-
-
Nyland, H.1
Mork, S.2
Matre, R.3
-
30
-
-
0020676803
-
Multiple sclerosis: distribution of T cell subsets within active chronic lesions
-
Traugott U, Reinherz EL, Raine CS, (1983) Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science 219: 308-310.
-
(1983)
Science
, vol.219
, pp. 308-310
-
-
Traugott, U.1
Reinherz, E.L.2
Raine, C.S.3
-
31
-
-
0022459287
-
Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
-
Hauser SL, Bhan AK, Gilles F, Kemp M, Kerr C, et al. (1986) Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann Neurol 19: 578-587.
-
(1986)
Ann Neurol
, vol.19
, pp. 578-587
-
-
Hauser, S.L.1
Bhan, A.K.2
Gilles, F.3
Kemp, M.4
Kerr, C.5
-
32
-
-
0022644493
-
Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth
-
Woodroofe MN, Bellamy AS, Feldmann M, Davison AN, Cuzner ML, (1986) Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth. J Neurol Sci 74: 135-152.
-
(1986)
J Neurol Sci
, vol.74
, pp. 135-152
-
-
Woodroofe, M.N.1
Bellamy, A.S.2
Feldmann, M.3
Davison, A.N.4
Cuzner, M.L.5
-
33
-
-
42549126264
-
The role of regulatory T cells in malignant glioma
-
Sonabend AM, Rolle CE, Lesniak MS, (2008) The role of regulatory T cells in malignant glioma. Anticancer Res 28: 1143-1150.
-
(2008)
Anticancer Res
, vol.28
, pp. 1143-1150
-
-
Sonabend, A.M.1
Rolle, C.E.2
Lesniak, M.S.3
-
34
-
-
77950805151
-
Peptide vaccination breaks tolerance to HER-2/neu by generating vaccine-specific FasL(+) CD4(+) T cells: first evidence for intratumor apoptotic regulatory T cells
-
Gritzapis AD, Voutsas IF, Lekka E, Papamichail M, Baxevanis CN, (2010) Peptide vaccination breaks tolerance to HER-2/neu by generating vaccine-specific FasL(+) CD4(+) T cells: first evidence for intratumor apoptotic regulatory T cells. Cancer Res 70: 2686-2696.
-
(2010)
Cancer Res
, vol.70
, pp. 2686-2696
-
-
Gritzapis, A.D.1
Voutsas, I.F.2
Lekka, E.3
Papamichail, M.4
Baxevanis, C.N.5
-
35
-
-
33847010275
-
Depleting intratumoral CD4+CD25+ regulatory T cells via FasL protein transfer enhances the therapeutic efficacy of adoptive T cell transfer
-
Chen A, Liu S, Park D, Kang Y, Zheng, (2007) Depleting intratumoral CD4+CD25+ regulatory T cells via FasL protein transfer enhances the therapeutic efficacy of adoptive T cell transfer. Cancer Res 67: 1291-1298.
-
(2007)
Cancer Res
, vol.67
, pp. 1291-1298
-
-
Chen, A.1
Liu, S.2
Park, D.3
Kang, Y.4
Zheng5
-
36
-
-
33847403673
-
Enhanced antitumor responses elicited by combinatorial protein transfer of chemotactic and costimulatory molecules
-
Liu S, Breiter DR, Zheng G, Chen A, (2007) Enhanced antitumor responses elicited by combinatorial protein transfer of chemotactic and costimulatory molecules. J Immunol 178: 3301-3306.
-
(2007)
J Immunol
, vol.178
, pp. 3301-3306
-
-
Liu, S.1
Breiter, D.R.2
Zheng, G.3
Chen, A.4
-
37
-
-
43049174722
-
Central role of defective Interleukin-2 production in the triggering of islet autoimmune destruction
-
Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, et al. (2008) Central role of defective Interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28: 687-697.
-
(2008)
Immunity
, vol.28
, pp. 687-697
-
-
Tang, Q.1
Adams, J.Y.2
Penaranda, C.3
Melli, K.4
Piaggio, E.5
-
38
-
-
55849126729
-
Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis
-
Michel L, Berthelot L, Pettré S, Wiertlewski S, Lefrère F, et al. (2008) Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis. J Clin Invest 118: 3411-3419.
-
(2008)
J Clin Invest
, vol.118
, pp. 3411-3419
-
-
Michel, L.1
Berthelot, L.2
Pettré, S.3
Wiertlewski, S.4
Lefrère, F.5
-
39
-
-
0020686503
-
New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann
-
Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, et al. (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol 13: 227-231.
-
(1983)
Neurol
, vol.13
, pp. 227-231
-
-
Poser, C.M.1
Paty, D.W.2
Scheinberg, L.3
McDonald, W.I.4
Davis, F.A.5
-
40
-
-
27644552194
-
Cortical demyelination and diffuse white matter injury in multiple sclerosis
-
Kutzelnigg A, Lucchinetti CF, Stadelmann C, Brück W, Rauschka H, et al. (2005) Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 128: 2705-2712.
-
(2005)
Brain
, vol.128
, pp. 2705-2712
-
-
Kutzelnigg, A.1
Lucchinetti, C.F.2
Stadelmann, C.3
Brück, W.4
Rauschka, H.5
-
41
-
-
0001612484
-
The neuropathology of multiple sclerosis
-
In: Vinken PJ, Bruyn GW, Klawans HL, editors
-
Prineas JW, (1985) The neuropathology of multiple sclerosis. In: Vinken PJ, Bruyn GW, Klawans HL, editors. Handbook of clinical neurology pp. 213-257.
-
(1985)
Handbook of Clinical Neurology
, pp. 213-257
-
-
Prineas, J.W.1
-
42
-
-
0028843731
-
Monocyte/macrophage differentiation in early multiple sclerosis lesions
-
Brück W, Porada P, Poser S, Rieckmann P, Hanefeld F, et al. (1995) Monocyte/macrophage differentiation in early multiple sclerosis lesions. Ann Neurol 38: 788-796.
-
(1995)
Ann Neurol
, vol.38
, pp. 788-796
-
-
Brück, W.1
Porada, P.2
Poser, S.3
Rieckmann, P.4
Hanefeld, F.5
-
43
-
-
0034955141
-
Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis
-
McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, et al. (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50: 121-127.
-
(2001)
Ann Neurol
, vol.50
, pp. 121-127
-
-
McDonald, W.I.1
Compston, A.2
Edan, G.3
Goodkin, D.4
Hartung, H.P.5
-
44
-
-
78649600894
-
Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis
-
Schneider-Hohendorf Stenner MP, Weidenfeller C, Zozulya AL, Simon OJ, et al. (2010) Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis. Eur J Immunol 40: 3581-90.
-
(2010)
Eur J Immunol
, vol.40
, pp. 3581-3590
-
-
Schneider-Hohendorf Stenner, M.P.1
Weidenfeller, C.2
Zozulya, A.L.3
Simon, O.J.4
-
45
-
-
77954141914
-
FOXP3+ regulatory T cells in the human immune system
-
Sakaguchi S, Miyara M, Costantino CM, Hafler DA, (2010) FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 10: 490-500.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 490-500
-
-
Sakaguchi, S.1
Miyara, M.2
Costantino, C.M.3
Hafler, D.A.4
|