Caenorhabditis elegans aristaless/Arx gene alr-1 restricts variable gene expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 10, 2011, Pages 4063-4068

  Topalidou, Irini ^a   Van Oudenaarden, Alexander ^b   Chalfie, Martin ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Aristaless family; LIM homeodomain proteins; Stochastic gene expression; Terminal differentiation

Indexed keywords

ALR 1 GENE; ARTICLE; ARX GENE; AUTOREGULATION; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; CELL FUNCTION; DROSOPHILA; GENE; GENE EXPRESSION; IN SITU HYBRIDIZATION; MEC 3 GENE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SENSORY NERVE CELL; TOUCH RECEPTOR NEURON; UNC 86 GENE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION, FLUORESCENCE; MUTATION; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC;

CAENORHABDITIS ELEGANS;

EID: 79952749335     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101329108     Document Type: Article

References (50)

1. Lanjuin A, VanHoven MK, Bargmann CI, Thompson JK, Sengupta P (2003) Otx/otd homeobox genes specify distinct sensory neuron identities in C. elegans. Dev Cell 5:621-633. (Pubitemid 37243050)
2. Lalucque H, Silar P (2004) Incomplete penetrance and variable expressivity of a growth defect as a consequence of knocking out two K(+) transporters in the euascomycete fungus Podospora anserina. Genetics 166:125-133. (Pubitemid 38364708)
3. Johnston RJ, Jr., et al. (2006) An unusual Zn-finger/FH2 domain protein controls a left/right asymmetric neuronal fate decision in C. elegans. Development 133:3317-3328.
4. Raj A, van Oudenaarden A (2008) Nature, nurture, or chance: Stochastic gene expression and its consequences. Cell 135:216-226.
5. García-Bellido A (1975) Genetic control of wing disc development in Drosophila. Ciba Found Symp 0:161-182.
6. Hobert O (2008) Regulatory logic of neuronal diversity: Terminal selector genes and selector motifs. Proc Natl Acad Sci USA 105:20067-20071.
7. Hobert O (2005) Specification of the nervous system. WormBook 1-19.
8. Colman A, Dreesen O (2009) Induced pluripotent stem cells and the stability of the differentiated state. EMBO Rep 10:714-721.
9. Chalfie M, Sulston J (1981) Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans. Dev Biol 82:358-370.
10. Chalfie M, Au M (1989) Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Science 243:1027-1033. (Pubitemid 19072579)
11. Finney M, Ruvkun G, Horvitz HR (1988) The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell 55:757-769.
12. Way JC, Chalfie M (1988) mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Cell 54:5-16.
13. Way JC, Chalfie M (1989) The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types. Genes Dev 3(12A):1823-1833. (Pubitemid 20023210)
14. Xue D, Finney M, Ruvkun G, Chalfie M (1992) Regulation of the mec-3 gene by the C. elegans homeoproteins UNC-86 and MEC-3. EMBO J 11:4969-4979. (Pubitemid 23023441)
15. Xue D, Tu Y, Chalfie M (1993) Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3. Science 261:1324-1328. (Pubitemid 24081169)
16. Lichtsteiner S, Tjian R (1995) Synergistic activation of transcription by UNC-86 and MEC-3 in Caenorhabditis elegans embryo extracts. EMBO J 14:3937-3945.
17. Duggan A, Ma C, Chalfie M(1998) Regulation of touch receptor differentiation by the Caenorhabditis elegans mec-3 and unc-86 genes. Development 125:4107-4119. (Pubitemid 28515448)
18. Röckelein I, Röhrig S, Donhauser R, Eimer S, Baumeister R (2000) Identification of amino acid residues in the Caenorhabditis elegans POU protein UNC-86 that mediate UNC-86-MEC-3-DNA ternary complex formation. Mol Cell Biol 20:4806-4813. (Pubitemid 30396127)
19. Tucker M, Sieber M, Morphew M, Han M (2005) The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs. Mol Biol Cell 16:4695-4704. (Pubitemid 41416452)
20. Melkman T, Sengupta P (2005) Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1. Development 132:1935-1949. (Pubitemid 40691782)
21. Campbell G, Weaver T, Tomlinson A (1993) Axis specification in the developing Drosophila appendage: The role of wingless, decapentaplegic, and the homeobox gene aristaless. Cell 74:1113-1123. (Pubitemid 23289467)
22. Schneitz K, Spielmann P, Noll M (1993) Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila. Genes Dev 7:114-129. (Pubitemid 23071205)
23. Kitamura K, et al. (2002) Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet 32:359-369. (Pubitemid 35266109)
24. Yoshihara S, Omichi K, Yanazawa M, Kitamura K, Yoshihara Y (2005) Arx homeobox gene is essential for development of mouse olfactory system. Development 132:751-762. (Pubitemid 40352834)
25. Bienvenu T, et al. (2002) ARX, a novel Prd-class-homeobox gene highly expressed in the telencephalon, is mutated in X-linked mental retardation. Hum Mol Genet 11:981-991. (Pubitemid 34449785)
26. Strømme P, Mangelsdorf ME, Scheffer IE, Gécz J (2002) Infantile spasms, dystonia, and other X-linked phenotypes caused by mutations in Aristaless related homeobox gene, ARX. Brain Dev 24:266-268.
27. Strømme P, Bakke SJ, Dahl A, Gécz J (2003) Brain cysts associated with mutation in the Aristaless related homeobox gene, ARX. J Neurol Neurosurg Psychiatry 74:536-538.
28. Gécz J, Cloosterman D, Partington M (2006) ARX: A gene for all seasons. Curr Opin Genet Dev 16:308-316.
29. Pueyo JI, Galindo MI, Bishop SA, Couso JP (2000) Proximal-distal leg development in Drosophila requires the apterous gene and the Lim1 homologue dlim1. Development 127:5391-5402. (Pubitemid 32050828)
30. Tsuji T, et al. (2000) Requirements of Lim1, a Drosophila LIM-homeobox gene, for normal leg and antennal development. Development 127:4315-4323.
31. Zhang Y, et al. (2002) Identification of genes expressed in C. elegans touch receptor neurons. Nature 418:331-335. (Pubitemid 34790684)
32. Calixto A, Ma C, Chalfie M (2010) Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans. Nat Methods 7:407-411.
33. Kojima T, Sato M, Saigo K (2000) Formation and specification of distal leg segments in Drosophila by dual Bar homeobox genes, BarH1 and BarH2. Development 127:769-778. (Pubitemid 30129023)
34. Pueyo JI, Couso JP (2004) Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development. Development 131:3107-3120. (Pubitemid 39077435)
35. Collombat P, et al. (2005) The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development 132:2969-2980. (Pubitemid 41086732)
36. Seufert DW, Prescott NL, El-Hodiri HM (2005) Xenopus aristaless-related homeobox (xARX) gene product functions as both a transcriptional activator and repressor in forebrain development. Dev Dyn 232:313-324. (Pubitemid 40129784)
37. Biressi S, et al. (2008) The homeobox gene Arx is a novel positive regulator of embryonic myogenesis. Cell Death Differ 15:94-104. (Pubitemid 350286177)
38. McKenzie O, et al. (2007) Aristaless-related homeobox gene, the gene responsible for West syndrome and related disorders, is a Groucho/transducin- like enhancer of split dependent transcriptional repressor. Neuroscience 146:236-247. (Pubitemid 46654626)
39. Maduro M, Pilgrim D (1995) Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141:977-988.
40. Zhao H, Nonet ML (2001) A conserved mechanism of synaptogyrin localization. Mol Biol Cell 12:2275-2289. (Pubitemid 33051956)
41. Finney M, Ruvkun G (1990) The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell 63:895-905. (Pubitemid 120034931)
42. Raj A, van den Bogaard P, Rifkin SA, van Oudenaarden A, Tyagi S (2008) Imaging individual mRNA molecules using multiple singly labeled probes. Nat Methods 5:877-879.
43. Niu W, et al. (2010) Diverse transcription factor binding features revealed by genome-wide ChIP-Seq in C. elegans. Genome Res 21:245-254.
44. Chalfie M, Thomson JN (1979) Organization of neuronal microtubules in the nematode Caenorhabditis elegans. J Cell Biol 82:278-289. (Pubitemid 9224602)
45. Raj A, Rifkin SA, Andersen E, van Oudenaarden A (2010) Variability in gene expression underlies incomplete penetrance. Nature 463:913-918.
46. Jin Y, Hoskins R, Horvitz HR (1994) Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein. Nature 372:780-783.
47. Campbell G, Tomlinson A (1998) The roles of the homeobox genes aristaless and Distalless in patterning the legs and wings of Drosophila. Development 125:4483-4493. (Pubitemid 28564292)
48. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
49. Gietz RD, Woods RA (2002) Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. Methods Enzymol 350:87-96. (Pubitemid 34619485)
50. Reynolds A, et al. (1997) Assay for β-galactosidase in liquid cultures. Curr Protoc Mol Biol 3:13-62.