Regulatory logic of neuronal diversity: Terminal selector genes and selector motifs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 51, 2008, Pages 20067-20071

  Hobert, Oliver ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Caenorhabditis elegans; cis regulatory motifs; Gene regulation; Neuronal differentiation; Transcription factors

Indexed keywords

TRANSCRIPTION FACTOR;

BACTERIAL GENE; CAENORHABDITIS ELEGANS; CELL TYPE; GENE; GENE EXPRESSION; GENE REGULATORY NETWORK; INTERNEURON; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENSORY NERVE CELL;

ANIMALS; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION; NEURONS; TRANSCRIPTION FACTORS;

CAENORHABDITIS ELEGANS;

EID: 58149484991     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806070105     Document Type: Review

References (50)

1. Cajal Ry (1911) Histologie du Système Nerveux de L'Homme et des Vertébrés (Maloine, Paris).
2. White JG, Southgate E, Thomson JN, Brenner S (1986) The structure of the nervous system of the nematode Caenorhabditis elegans. Philos Trans R Soc London Ser B 314:1-340.
3. Hobert O (2005) Specification of the nervous system. WormBook, eds The C. elegans Research Community, doi/10.1895/wormbook.1.12.1.
4. Etchberger JF, et al. (2007) The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. Genes Dev 21:1653-1674.
5. Chang S, Johnston RJ, Jr, Hobert O (2003) A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans. Genes Dev 17:2123-2137.
6. Uchida O, Nakano H, Koga M, Ohshima Y (2003) The C. elegans che-1 gene encodes a zinc finger transcription factor required for specification of the ASE chemosensory neurons. Development 130:1215-1224.
7. Tsalik EL, Hobert O (2003) Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. J Neurobiol 56:178-197.
8. Remy JJ, Hobert O (2005) An interneuronal chemoreceptor required for olfactory imprinting in C. elegans. Science 309:787-790.
9. Wenick AS, Hobert O (2004) Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans. Dev Cell 6:757-770.
10. Altun-Gultekin Z, et al. (2001) A regulatory cascade of three homeobox genes, ceh-10, ttx-3, and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. Development 128:1951-1969.
11. Way JC, Chalfie M (1988) mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Cell 54:5-16.
12. Chalfie M, Horvitz HR, Sulston JE (1981) Mutations that lead to reiterations in the cell lineages of C. elegans. Cell 24:59-69.
13. Finney M, Ruvkun G (1990) The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell 63:895-905.
14. Duggan A, Ma C, Chalfie M (1998) Regulation of touch receptor differentiation by the Caenorhabditis elegans mec-3 and unc-86 genes. Development 125:4107-4119.
15. Xue D, Finney M, Ruvkun G, Chalfie M (1992) Regulation of the mec-3 gene by the C. elegans homeoproteins UNC-86 and MEC-3. EMBO J 11:4969-4979.
16. Zhang Y, et al. (2002) Identification of genes expressed in C. elegans touch receptor neurons. Nature 418:331-335.
17. Jin Y, Hoskins R, Horvitz HR (1994) Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein. Nature 372:780-783.
18. Cinar H, Keles S, Jin Y (2005) Expression profiling of GABAergic motor neurons in Caenorhabditis elegans. Curr Biol 15:340-346.
19. Lanjuin A, Sengupta P (2004) Specification of chemosensory neuron subtype identities in Caenorhabditis elegans. Curr Opin Neurobiol 14:22-30.
20. Garcia-Bellido A (1975) Genetic control of wing disc development in Drosophila. Ciba Found Symp 29:161-182.
21. Mann RS, Carroll SB (2002) Molecular mechanisms of selector gene function and evolution. Curr Opin Genet Dev 12:592-600.
22. Hobert O, et al. (1997) Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 19:345-357.
23. Way JC, Chalfie M (1989) The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types. Genes Dev 3:1823-1833.
24. Jan YN, Jan LY (1994) Neuronal cell fate specification in Drosophila. Curr Opin Neurobiol 4:8-13.
25. Guillemot F (2007) Spatial and temporal specification of neural fates by transcription factor codes. Development 134:3771-3780.
26. Cheng L, et al. (2004) Tlx3 and Tlx1 are postmitotic selector genes determining glutamatergic over GABAergic cell fates. Nat Neurosci 7:510-517.
27. Mangale VS, et al. (2008) Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science 319:304-309.
28. Sieber MA, et al. (2007) Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain. J Neurosci 27:4902-4909.
29. Nakatani T, Minaki Y, Kumai M, Ono Y (2007) Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. Development 134:2783-2793.
30. Nelson SB, Hempel C, Sugino K (2006) Probing the transcriptome of neuronal cell types. Curr Opin Neurobiol 16:571-576.
31. Masland RH (2004) Neuronal cell types. Curr Biol 14:R497-R500.
32. Hsiau TH, et al. (2007) The cis-regulatory logic of the mammalian photoreceptor transcriptional network. PLoS ONE 2:e643.
33. Chen S, et al. (1997) Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron 19:1017-1030.
34. Blackshaw S, Fraioli RE, Furukawa T, Cepko CL (2001) Comprehensive analysis of photoreceptor gene expression and the identification of candidate retinal disease genes. Cell 107:579-589.
35. Nishida A, et al. (2003) Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat Neurosci 6:1255-1263.
36. Koike C, et al. (2007) Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Mol Cell Biol 27:8318-8329.
37. Ranade SS, et al. (2008) Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates. Dev Biol 315:521-534.
38. Tahayato A, et al. (2003) Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina. Dev Cell 5:391-402.
39. Alon U (2007) Network motifs: Theory and experimental approaches. Nat Rev Genet 8:450-461.
40. Davidson EH (2001) Genomic Regulatory Systems (Academic, San Diego).
41. Mears AJ, et al. (2001) Nrl is required for rod photoreceptor development. Nat Genet 29:447-452.
42. Corbo JC, Cepko CL (2005) A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. PLoS Genet 1:e11.
43. Chen J, Rattner A, Nathans J (2005) The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes. J Neurosci 25:118-129.
44. Hobert O (2006) Architecture of a microRNA-controlled gene regulatory network that diversifies neuronal cell fates. Cold Spring Harb Symp Quant Biol 71:181-188.
45. Swoboda P, Adler HT, Thomas JH (2000) The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans. Mol Cell 5:411-421.
46. Ruvinsky I, Ohler U, Burge CB, Ruvkun G (2007) Detection of broadly expressed neuronal genes in C. elegans. Dev Biol 302:617-626.
47. Hwang SB, Lee J (2003) Neuron cell type-specific SNAP-25 expression driven by multiple regulatory elements in the nematode Caenorhabditis elegans. J Mol Biol 333:237-247.
48. Mitani S, Du H, Hall DH, Driscoll M, Chalfie M (1993) Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Development 119:773-783.
49. Baumeister R, Liu Y, Ruvkun G (1996) Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes Dev 10:1395-1410.
50. Hagman J, Lukin K (2007) "Hands-on" regulation of B cell development by the transcription factor Pax5. Immunity 27:8-10.