Design, modeling, fabrication, and evaluation of the air amplifier for improved detection of biomolecules by electrospray ionization mass spectrometry

International Journal of Mass Spectrometry

Volumn 300, Issue 2-3, 2011, Pages 99-107

  Robichaud, Guillaume ^b   Dixon, R Brent ^a   Potturi, Amarnatha S ^b   Cassidy, Dan ^b   Edwards, Jack R ^b   Sohn, Alex ^b   Dow, Thomas A ^b   Muddiman, David C ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b North Carolina State University   (United States)

Author keywords

Air amplifier; Detection limits; Electrospray ionization; Modeling

Indexed keywords

EID: 79952740644     PISSN: 13873806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijms.2010.04.006     Document Type: Article

References (31)

1. J.B. Fenn, M. Mann, C.K. Meng, S.F. Wong, and C.M. Whitehouse Electrospray ionization for mass-spectrometry of large biomolecules Science 246 4926 1989 64 71 (Pubitemid 19252085)
2. J.B. Fenn, M. Mann, C.K. Meng, S.F. Wong, and C.M. Whitehouse Electrospray ionization - principles and practice Mass Spectrom. Rev. 9 1 1990 37 70
3. J.B. Fenn Ion formation from charged droplets - roles of geometry, energy, and time J. Am. Soc. Mass Spectrom. 4 7 1993 524 535
4. C.M Whitehouse, R.N. Dreyer, M. Yamashita, and J.B. Fenn Electrospray interface for liquid chromatographs and mass spectrometers Anal. Chem. 57 3 1985 675 679 (Pubitemid 15479593)
5. K. Hiraoka, and I. Kudaka Electrospray interface for liquid- chromatography mass-spectrometry Rapid Commun. Mass Spectrom. 4 12 1990 519 526
6. R.D. Smith, J.A. Loo, C.G. Edmonds, C.J. Barinaga, and H.R. Udseth New developments in biochemical mass-spectrometry - electrospray ionization Anal. Chem. 62 9 1990 882 899
7. D. Figeys, and D. Pinto Proteomics on a chip: promising developments Electrophoresis 22 2 2001 208 216
8. J.S. Kim, and D.R. Knapp Miniaturized multichannel electrospray ionization emitters on poly(dimethylsiloxane) microfluidic devices Electrophoresis 22 18 2001 3993 3999 (Pubitemid 33040219)
9. B.C. Nadja, and G.E. Christie Practical implications of some recent studies in electrospray ionization fundamentals Mass Spectrom. Rev. 20 6 2001 362 387
10. S. Tiina, F. Sami, J.K. Tiina, K. Risto, K. Tapio, and A.K. Raimo Microchip technology in mass spectrometry Mass Spectrom. Rev. 29 2010 351 391
11. P. Kebarle, and L. Tang From ions in solution to ions in the gas-phase - the mechanism of electrospray mass-spectrometry Anal. Chem. 65 22 1993 A972 A986
12. L. Tang, and P. Kebarle Dependence of ion intensity in electrospray mass-spectrometry on the concentration of the analytes in the electrosprayed solution Anal. Chem. 65 24 1993 3654 3668
13. D.R. Zook, and A.P. Bruins On cluster ions, ion transmission, and linear dynamic range limitations in electrospray (ionspray) mass spectrometry Int. J. Mass Spectrom. Ion Phys. 162 1-3 1997 129 147 (Pubitemid 127736992)
14. A.P. Bruins Mechanistic aspects of electrospray ionization J. Chromatogr. A 794 1-2 1998 345 357 (Pubitemid 28083620)
15. O. Wilhelm, L. Madler, and S.E. Pratsinis Electrospray evaporation and deposition J. Aerosol. Sci. 34 7 2003 815 836 (Pubitemid 36870732)
16. G.J. Van Berkel, and V. Kertesz Using the electrochemistry of the electrospray ion source Anal. Chem. 79 15 2007 5510 5520 (Pubitemid 47229794)
17. D.C. Muddiman "Lewis and Clark" proteomics J. Proteome Res. 5 2 2006 221 222
18. I.A. Buryakov, E.V. Krylov, E.G. Nazarov, and U.K. Rasulev A new method of separation of multi-atomic ions by mobility at atmospheric-pressure using a high-frequency amplitude-asymmetric strong electric-field Int. J. Mass Spectrom. Ion Phys. 128 3 1993 143 148
19. R.W. Purves, and R. Guevremont Electrospray ionization high-field asymmetric waveform ion mobility spectrometry-mass spectrometry Anal. Chem. 71 13 1999 2346 2357 (Pubitemid 29307596)
20. D.A. Barnett, B. Ells, R. Guevremont, and R.W. Purves Application of ESI-FAIMS-MS to the analysis of tryptic peptides J. Am. Soc. Mass Spectrom. 13 11 2002 1282 1291 (Pubitemid 36875982)
21. S.A. Shaffer, K.Q. Tang, G.A. Anderson, D.C. Prior, H.R. Udseth, and R.D. Smith A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry Rapid Commun. Mass Spectrom. 11 16 1997 1813 1817 (Pubitemid 27498707)
22. T. Him, A.V. Tolmachev, R. Harkewicz, D.C. Prior, G. Anderson, H.R. Udseth, R.D. Smith, T.H. Bailey, S. Rakov, and J.H. Futrell Design and implementation of a new electrodynamic ion funnel Anal. Chem. 72 10 2000 2247 2255 (Pubitemid 30322287)
23. T. Kim, K.Q. Tang, H.R. Udseth, and R.D. Smith A multicapillary inlet jet disruption electrodynamic ion funnel interface for improved sensitivity using atmospheric pressure ion sources Anal. Chem. 73 17 2001 4162 4170 (Pubitemid 32830855)
24. L. Zhou, B.F. Yue, D.V. Dearden, E.D. Lee, A.L. Rockwood, and M.L. Lee Incorporation of a Venturi device in electrospray ionization Anal. Chem. 75 21 2003 5978 5983 (Pubitemid 37356481)
25. A.M. Hawkridge, L. Zhou, M.L. Lee, and D.C. Muddiman Analytical performance of a Venturi device integrated into an electrospray ionization Fourier transform ion cyclotron resonance mass spectrometer for analysis of nucleic acids Anal. Chem. 76 14 2004 4118 4122 (Pubitemid 38943686)
26. P.X. Yang, R.G. Cooks, Z. Ouyang, A.M. Hawkridge, and D.C. Muddiman Gentle protein ionization assisted by high-velocity gas flow Anal. Chem. 77 19 2005 6174 6183 (Pubitemid 41439691)
27. R.B. Dixon, and D.C. Muddiman Quantitative comparison of a flared and standard heated metal capillary inlet with a voltage-assisted air amplifier on an electrospray ionization linear ion trap mass spectrometer Rapid Commun. Mass Spectrom. 21 19 2007 3207 3212 (Pubitemid 47441782)
28. R.B. Dixon, D.C. Muddiman, A.M. Hawkridge, and A.G. Fedorov Probing the mechanism of an air amplifier using a LTQ-FT-ICR-MS and fluorescence spectroscopy J. Am. Soc. Mass Spectrom. 18 11 2007 1909 1913 (Pubitemid 47633953)
29. C.Y. Hampton, T.P. Forbes, M.J. Varady, J.M. Meacham, A.G. Fedorov, F.L. Degertekin, and F.M. Fernandez Analytical performance of a Venturi-assisted array of micromachined ultrasonic electrosprays coupled to ion trap mass spectrometry for the analysis of peptides and proteins Anal. Chem. 79 21 2007 8154 8161 (Pubitemid 350060012)
30. L. Zhou, L.L. Zhai, B.F. Yue, E.D. Lee, and M.L. Lee New interface plate for microspray ionization mass spectrometry Anal. Bioanal. Chem. 385 6 2006 1087 1091 (Pubitemid 43992166)
31. M.L. Jackson Aeration in Bernoulli types of devices AIChE J. 10 6 1964 836 842